Research Work on Projects of the Works Progress Administration
Author | : United States. Works Progress Administration |
Publisher | : |
Total Pages | : 20 |
Release | : 1938 |
Genre | : Public service employment |
ISBN | : |
Download Investigation And Study Of The Work Projects Administration Formerly Works Progress Administration Hearings 76th Congress 3d Session Pts3 4 Pts1 2 Were Titled Investigation And Study Of The Works Progress Administration full books in PDF, epub, and Kindle. Read online free Investigation And Study Of The Work Projects Administration Formerly Works Progress Administration Hearings 76th Congress 3d Session Pts3 4 Pts1 2 Were Titled Investigation And Study Of The Works Progress Administration ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author | : United States. Works Progress Administration |
Publisher | : |
Total Pages | : 20 |
Release | : 1938 |
Genre | : Public service employment |
ISBN | : |
Author | : United States. Work Projects Administration |
Publisher | : |
Total Pages | : 7 |
Release | : 1936 |
Genre | : Public works |
ISBN | : |
Author | : Jong Hoon Park |
Publisher | : Springer |
Total Pages | : 128 |
Release | : 2016-10-12 |
Genre | : Medical |
ISBN | : 9811020418 |
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.