This book explores the interactions of local inhabitants and environmental systems in the Protected Natural Areas of Mexico. Its goal is to help understand how social groups contextualize ecological knowledge, how human activities contribute to modifying the environmental matrix, how cultural and economic aspects influence the use, management and conservation of their ecological environment, and how social phenomena are to be viewed against the backdrop of ecological knowledge. The book reviews the epistemological and historical bases of the socio-ecological relationship, and addresses the evolution of human-natural systems. From a methodological standpoint, it assesses the tools required for the integration of “human” and “natural” dimensions in the management of the environmental matrix. Further, in the case studies section, it reviews valuable recent experiences concerning the retro-interactions of local inhabitants with their environmental matrix. Given its scope, the book offers a valuable asset for researchers and professionals all over the world, especially those working in Latin American countries.