Introduction to Stereochemistry

Introduction to Stereochemistry
Author: Kurt Mislow
Publisher: Courier Corporation
Total Pages: 210
Release: 2012-06-11
Genre: Science
ISBN: 0486151158

Molecular shape, form, and symmetry play a central role in organic chemistry, and this text presents a brief introduction to the conceptual basis of stereochemistry. Its focus lies in the fundamentals of structural stereochemistry, rather than the dynamic aspects that are more relevant to reaction mechanisms. The three-part treatment deals with structure and symmetry, stereoisomerism, and the separation and configuration of stereoisomers. The first section reviews molecular architecture, relating empirical bonding geometries to the hybridization of the central carbon atom. Students receive a nonrigorous treatment of symmetry elements and point groups, with particular focus on the presence or absence of reflection symmetry. The second section classifies stereoisomers according to symmetry properties and to the nature of their barriers; it also discusses the dependence of optical activity on structure and concludes with an examination of topological isomerism. The third and final section explores the conceptual basis of asymmetric syntheses and kinetic resolutions. Each of the major sections features a series of exercises that reinforce and extend the preceding material, and answers are provided. Preface to the Dover edition. Answers to Exercises. Bibliography. Index.

Introduction to Stereochemistry

Introduction to Stereochemistry
Author: Andrew Clark
Publisher: Royal Society of Chemistry
Total Pages: 201
Release: 2023-01-17
Genre: Science
ISBN: 1839164131

CHEMISTRY STUDENT GUIDES. GUIDED BY STUDENTS Why did the drug thalidomide cause birth defects? What is the chemical difference between sucrose and lactose in your food? Stereochemistry holds the answer and is essential to the understanding of the chemistry of life. Stereochemistry is an important concept that often causes confusion amongst students when they learn it for the first time. Unlike most other areas of chemistry, it requires the chemist to visualise molecules in 3D, which can be difficult. In this book we deal with tricky concepts like conformation and configuration, how to represent them accurately and how to use the correct terms to describe them in both organic and inorganic chemistry. We involved students in the writing process to ensure we deal with areas that you find difficult, in an understandable language. With problems designed to focus on common errors and misconceptions, real life examples, and practical hands-on exercises coupled with visualisation tips, our intention is to give you the tools to become confident in stererochemistry. Complementing mainstream organic textbooks, or self-study, this book is for anyone who has struggled with describing alkenes as E or Z, assigning R and S absolute configurations, drawing Newman projections or chair representations of cyclohexanes, axial chirality, understanding the stereochemistry of octahedral metal complexes and indeed explaining complexities observed in NMR spectra. Chemistry Student Guides are written with current students involved at every stage, guiding the books towards the most challenging aspects of the topic. Student co-authors for Introduction to Stereochemistry are Caroline Akamune, Michael Lloyd and Matthew Taylor.

Introduction to Stereochemistry

Introduction to Stereochemistry
Author: Torsten Schmiermund
Publisher: Springer Nature
Total Pages: 56
Release: 2021-06-07
Genre: Science
ISBN: 3658320354

Conformal, diastereomers, rotamers, tautomers, anomers: The multitude of terms used in stereochemistry quickly makes this subfield of chemistry confusing. In addition, there are different nomenclatures and different forms of representation (Fischer projection, Haworth ring formula, Newman projection). This essential deals with basic static stereochemistry and gives an overview of the different isomeric forms and nomenclatures. It is thus both a help and a reference book. This Springer essential is a translation of the original German 1st edition essentials, Einführung in die Stereochemie by Torsten Schmiermund, published by Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2019. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.

Basic Organic Stereochemistry

Basic Organic Stereochemistry
Author: Ernest L. Eliel
Publisher: Wiley-Interscience
Total Pages: 712
Release: 2001-04-11
Genre: Science
ISBN:

A Practical Introduction to Stereochemistry Stereoisomers are compounds with the same chemical formula and connectivity but with different arrangements of their atoms in 3-dimensional space. Stereochemistry encompasses the study of stereoisomers and their properties. Despite having an identical chemical formula, stereoisomers can have drastically different biological, medicinal, and chemical properties. Basic Organic Stereochemistry explains in clear, concise terms the concepts and properties of stereoisomers. Ideal both as a text for advanced undergraduate or graduate students and as a handy guide for researchers in industry, this superb text covers: * Polarimetry and optical rotation * Internal coordinates, configuration, and conformation * Nature of stereoisomers * Barriers between stereoisomers and residual stereoisomers * Symmetry operators and symmetry point groups * Properties of stereoisomers and stereoisomer discrimination * Separation of stereoisomers, resolution, and racemization Suitable for students in organic and biological chemistry, Basic Organic Stereochemistry is unparalleled as a convenient text.

Organic Stereochemistry

Organic Stereochemistry
Author: Hua-Jie Zhu
Publisher: John Wiley & Sons
Total Pages: 336
Release: 2015-08-10
Genre: Science
ISBN: 3527338225

Adopting a novel approach to the topic by combining theoretical knowledge and practical results, this book presents the most popular and useful computational and experimental methods applied for studying the stereochemistry of chemical reactions and compounds. The text is clearly divided into three sections on fundamentals, spectroscopic and computational techniques, and applications in organic synthesis. The first part provides a brief introduction to the field of chirality and stereochemistry, while the second part covers the different methodologies, such as optical rotation, electronic circular dichroism, vibrational circular dicroism, and Raman spectroscopy. The third section then goes on to describe selective examples in organic synthesis, classified by reaction type, i.e. enantioselective, chemoselective and stereoselective reactions. A final chapter on total synthesis of natural products rounds off the book. A valuable reference for researchers in academia and industry working in the field of organic synthesis, computational chemistry, spectroscopy or medicinal chemistry.

Basic Concepts in Organic Stereochemistry

Basic Concepts in Organic Stereochemistry
Author: Sunil Kumar Talapatra
Publisher: Springer Nature
Total Pages: 266
Release: 2023-01-01
Genre: Science
ISBN: 3030959902

This book discusses essential stereochemical concepts associated with organic molecules (natural or synthetic), as reflected in the course of their many reactions, their mechanisms, their asymmetric synthesis, biosynthesis, and biological activities. This treatise provides useful insights and understanding of the chiral/achiral designations (nomenclatures), the stereochemical features, and related properties of the natural and synthetic products. Without having an adequate knowledge of stereochemical concepts, it will not be possible to understand and appreciate the stereochemistry of natural or synthetic products. Thus, essential static and dynamic aspects of stereochemistry with sufficient illustrative examples along with discussions are presented. The structure of the monograph allows for easy selection of separate topics for reading and teaching. This book will also provide an idea of basic stereochemical concepts, as applied to organic molecules in general as well as to organic ligands in coordination complexes, and will, therefore, be valuable resources to teachers and students of advanced undergraduates and post-graduates, researchers, and professionals.

Introduction to Stereochemistry and Conformational Analysis

Introduction to Stereochemistry and Conformational Analysis
Author: Eusebio Juaristi
Publisher: Wiley-Interscience
Total Pages: 360
Release: 1991-10-30
Genre: Science
ISBN:

This textbook covers the most important aspects of what remains an actively changing area of knowledge. Topics include chirality, the determination of absolute configurations, stereochemical descriptors, chiroptic properties, asymmetric synthesis, and the resolution of racemates.

Stereochemistry and Organic Reactions

Stereochemistry and Organic Reactions
Author: Dipak Kumar Mandal
Publisher: Academic Press
Total Pages: 640
Release: 2021-04-21
Genre: Science
ISBN: 0128240938

Stereochemistry and Organic Reactions: Conformation, Configuration, Stereoelectronic Effects and Asymmetric Synthesis provides coverage on the stereochemistry of reactions of all mechanistic types, ranging from ionic, pericyclic and transition metal-catalyzed to radical and photochemical. Chapters cover acyclic molecules, cyclic molecules, the stereochemistry of organic reactions, the perturbation molecular orbital theory for the origin of stereoelectronic effects, and an introduction to the principles of stereoselectivity and hierarchical levels of asymmetric synthesis. Each chapter includes problems that reinforce main themes, making it valuable to students, teachers and researchers working in organic, biological and medicinal chemistry, as well as biologists, pharmacologists, polymer chemists and chemists. Presents a holistic and unified approach to stereochemical understanding and predictions, covering reactions of all mechanistic classes Includes two background chapters on perturbation theory and stereoselective principles, along with asymmetric designs Features novel rules and mnemonics to delineate product stereochemistry Includes up-to-date coverage with over 1300 selective references

Stereochemistry of Organic Compounds

Stereochemistry of Organic Compounds
Author: Ernest L. Eliel
Publisher: John Wiley & Sons
Total Pages: 1296
Release: 1994-09-28
Genre: Science
ISBN: 0471016705

Stereochemistry of Organic Compounds The first fully referenced, comprehensive book on this subject in more than thirty years, Stereochemistry of Organic Compounds contains up-to-date coverage and insightful exposition of all important new concepts, developments, and tools in the rapidly advancing field of stereochemistry, including: * Asymmetric and diastereoselective synthesis * Conformational analysis * Properties of enantiomers and racemates * Separation and analysis of enantiomers and diastereoisomers * Developments in spectroscopy (including NMR), chromatography, and molecular mechanics as applied to stereochemistry * Prostereoisomerism * Conceptual foundations of stereochemistry, including terminology and symmetry concepts * Chiroptical properties Written by the leading authorities in the field, the text includes more than 4,000 references, 1,000 illustrations, and a glossary of stereochemical terms.

Inorganic Stereochemistry

Inorganic Stereochemistry
Author: D. L. Kepert
Publisher: Springer Science & Business Media
Total Pages: 239
Release: 2012-12-06
Genre: Science
ISBN: 3642680461

Molecular stereochemistry is a fundamental aspect of all areas of chemistry. It is especially important in inorganic chemistry where the coordination numbers are variable and occasionally quite high. The present book evolved naturally from a series of articles written by Professor Kepert for Progre88 in Inorganic Ohemi8try, elucida ting aspects of the stereochemistry of inorganic compounds of co ordination numbers 4-12. In the present volume, Professor Kepert has added new sections and synthesized these individual chapters into a unified treatment, updating his references when necessary to the most recent contributions in the literature, and inter weaving the various themes as deemed appropriate. The result is a major contribution, describing the stereochemistry of coordi nation compounds having both unidentate and multidentate ligands. The viability of the repulsion approach to stereochemistry is tested to the limit in this treatise and shown to be an extremely good way of rationalizing a diverse body of data.