Integration Interaction Of Oncologic Growth
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Author | : Gary G. Meadows |
Publisher | : Springer |
Total Pages | : 454 |
Release | : 2009-09-03 |
Genre | : Medical |
ISBN | : 9789048103065 |
A unique book on the interactions and interrelationships between tumor and host that modulate progression and metastasis. Several authors emphasize targeting the host rather than the tumor itself for therapeutic intervention to control cancer.
Author | : Gary G. Meadows |
Publisher | : Springer Science & Business Media |
Total Pages | : 459 |
Release | : 2005-11-10 |
Genre | : Medical |
ISBN | : 1402034148 |
A unique book on the interactions and interrelationships between tumor and host that modulate progression and metastasis. Several authors emphasize targeting the host rather than the tumor itself for therapeutic intervention to control cancer.
Author | : Felix Kratz |
Publisher | : John Wiley & Sons |
Total Pages | : 1828 |
Release | : 2013-09-30 |
Genre | : Medical |
ISBN | : 3527647759 |
In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.
Author | : G V Sherbet |
Publisher | : Elsevier |
Total Pages | : 368 |
Release | : 2011-07-12 |
Genre | : Science |
ISBN | : 0123878209 |
Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes Aids the development of therapeutic treatments for cancer Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research
Author | : Thomas Seyfried |
Publisher | : John Wiley & Sons |
Total Pages | : 482 |
Release | : 2012-05-18 |
Genre | : Science |
ISBN | : 1118310306 |
The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.
Author | : National Academies of Sciences, Engineering, and Medicine |
Publisher | : National Academies Press |
Total Pages | : 175 |
Release | : 2019-08-30 |
Genre | : Medical |
ISBN | : 0309492319 |
Throughout history, perhaps no other disease has generated the level of social, scientific, and political discourse or has had the degree of cultural significance as cancer. A collective in the truest sense of the word, "cancer" is a clustering of different diseases that afflict individuals in different ways. Its burdens are equally broad and diverse, from the physical, financial, and psychological tolls it imposes on individuals to the costs it inflicts upon the nation's clinical care and public health systems, and despite decades of concerted efforts often referred to as the "war on cancer", those costs have only continued to grow over time. The causes and effects of cancer are complexâ€"in part preventable and treatable, but also in part unknown, and perhaps even unknowable. Guiding Cancer Control defines the key principles, attributes, methods, and tools needed to achieve the goal of implementing an effective national cancer control plan. This report describes the current structure of cancer control from a local to global scale, identifies necessary goals for the system, and formulates the path towards integrated disease control systems and a cancer-free future. This framework is a crucial step in establishing an effective, efficient, and accountable system for controlling cancer and other diseases.
Author | : Arthur James Wells |
Publisher | : |
Total Pages | : 1664 |
Release | : 2005 |
Genre | : Bibliography, National |
ISBN | : |
Author | : Manish I. Patel |
Publisher | : Springer Science & Business Media |
Total Pages | : 173 |
Release | : 2010-09-08 |
Genre | : Technology & Engineering |
ISBN | : 3642156029 |
Model integration – the process by which different modelling efforts can be brought together to simulate the target system – is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale. A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules. The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.
Author | : Michael B. Sporn |
Publisher | : Springer Science & Business Media |
Total Pages | : 177 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642773834 |
It is now apparent that several fields of investigation are converging upon each other as the goal of finding a practical way to prevent cancer is pursued. The present monograph represents the efforts of an interdisciplinary ESO Task Force that was convened to assess interactions of peptide growth factors and steroid-like molecules in the prevention of cancer. Each of the participants in the Task Force represents a differentscientific discipline, and the monogrph is intended to be a synthesis of their different approaches to the common problem of cancer prevention. It is hoped that the reader will find this monograph to be of use in the evaluation of both preclinical and clinical approaches to the major issues that face us in chemoprevention. It is clear that prevention of cancer is an idea whose time has come, and the problem now is to implement the most effective approaches toward achieving the desired goals.
Author | : Gary K. Schwartz |
Publisher | : Springer Science & Business Media |
Total Pages | : 289 |
Release | : 2005 |
Genre | : Medical |
ISBN | : 1588292002 |
Expert physician-scientists and clinicians review those combinations of novel target agents classic chemotherapies that hold the most promise for the future of medical oncology, and detail their optimal sequence, pharmacokinetic interactions, and interaction with downstream cellular signals. The combinations run the gamut of targeted therapies against cell surface receptors (EGF-R and HER2), the cell cycle (the CDKs), signal transduction events (PKC and NF-kB), apoptosis (bcl-2), as well as focused therapies in ovarian cancer, hematologic diseases, and breast cancer. The authors emphasize novel translational approaches that are rapidly moving from the laboratory bench top to the patient's bedside for the future treatments in cancer therapy.