Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis

Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis
Author: Karl Bechter
Publisher: Frontiers Media SA
Total Pages: 189
Release: 2019-08-12
Genre:
ISBN: 2889459500

Growing evidence derived from cerebrospinal fluid (CSF), neuropathological, imaging, genetic, and epidemiological studies link neuroinflammation and immune dysregulation to a subset of individuals with a variety of severe mental disorders (SMDs), including affective and non-affective psychotic disorders. Further, the recent discoveries of neuronal surface antibodies (NSAs) in autoimmune encephalitis (AE) presenting with diverse neuropsychiatric disorders such as psychosis and cognitive decline, among many others, provides further support to the notion that CNS autoimmunity and neuroinflammation can contribute to the neurobiology of psychiatric disturbances. Further, these immune mechanisms may contribute to a subset of patients currently diagnosed as having treatment-resistant SMDs such as schizophrenia and major depressive disorder. Additionally, mounting data indicate that various infections can serve as an immunological trigger of aberrant immune responses, presumably by causing release of excess neural antigen, thereby giving rise to NSAs or aberrant immune cellular responses to give rise to primary or secondary psychiatric disorders such as schizophrenia and those associated with AE, respectively. Collectively, these findings support the “mild encephalitis” hypothesis of SMD. The significant overlap among AE-associated psychosis, systemic autoimmune disorder-associated psychosis, and psychotic disorders associated with pathological processes involving inflammation and immune dysregulation has also prompted some authors to adopt the term “autoimmune psychosis” (AP). This term reflects that this psychosis subtype is mechanistically linked to complex neuroimmune and inflammatory signalling abnormalities that can be responsive to early immunomodulatory treatment. It also suggests that a subset of AP might represent an incomplete or “forme fruste” subtype of AE presenting with dominant or pure psychiatric symptoms mimicking primary psychiatric illnesses. Because data indicate that delayed diagnosis and treatment may lead to permanent sequelae, early recognition of AP utilizing neurodiagnostic workup (e.g., CSF analysis, neuroimaging, and EEG) and its early treatment with appropriate immunotherapy are paramount to a meaningful recovery. This eBook will provide an overview of the current knowledge and research areas from epidemiology, risk factors and diagnosis to the management of these conditions, in this rapidly emerging field, helping to bridge the gaps in knowledge that currently exist in the disciplines of Psychiatry, Neurology, and Neuroimmunology.

Culinary Linguistics

Culinary Linguistics
Author: Cornelia Gerhardt
Publisher: John Benjamins Publishing
Total Pages: 365
Release: 2013-07-04
Genre: Language Arts & Disciplines
ISBN: 9027271712

Language and food are universal to humankind. Language accomplishes more than a pure exchange of information, and food caters for more than mere subsistence. Both represent crucial sites for socialization, identity construction, and the everyday fabrication and perception of the world as a meaningful, orderly place. This volume on Culinary Linguistics contains an introduction to the study of food and an extensive overview of the literature focusing on its role in interplay with language. It is the only publication fathoming the field of food and food-related studies from a linguistic perspective. The research articles assembled here encompass a number of linguistic fields, ranging from historical and ethnographic approaches to literary studies, the teaching of English as a foreign language, psycholinguistics, and the study of computer-mediated communication, making this volume compulsory reading for anyone interested in genres of food discourse and the linguistic connection between food and culture. Now Open Access as part of the Knowledge Unlatched 2017 Backlist Collection.

Revolutionary War Records

Revolutionary War Records
Author: Gaius Marcus Brumbaugh
Publisher:
Total Pages: 0
Release: 2000-09
Genre: Bounties, Military
ISBN: 9780806300603

Given in memory of Charles Hudson Edge, Laura James Edge, by Eugene Edge III.

The Guns of Independence

The Guns of Independence
Author: Jerome A. Greene
Publisher: Savas Beatie
Total Pages: 762
Release: 2005-04-19
Genre: History
ISBN: 1611210054

A modern, scholarly account of the most decisive campaign during the American Revolution examining the artillery, tactics and leadership involved. The siege of Yorktown in the fall of 1781 was the single most decisive engagement of the American Revolution. The campaign has all the drama any historian or student could want: the war’s top generals and admirals pitted against one another; decisive naval engagements; cavalry fighting; siege warfare; night bayonet attacks; and much more. Until now, however, no modern scholarly treatment of the entire campaign has been produced. By the summer of 1781, America had been at war with England for six years. No one believed in 1775 that the colonists would put up such a long and credible struggle. France sided with the colonies as early as 1778, but it was the dispatch of 5,500 infantry under Comte de Rochambeau in the summer of 1780 that shifted the tide of war against the British. In early 1781, after his victories in the Southern Colonies, Lord Cornwallis marched his army north into Virginia. Cornwallis believed the Americans could be decisively defeated in Virginia and the war brought to an end. George Washington believed Cornwallis’s move was a strategic blunder, and he moved vigorously to exploit it. Feinting against General Clinton and the British stronghold of New York, Washington marched his army quickly south. With the assistance of Rochambeau's infantry and a key French naval victory at the Battle off the Capes in September, Washington trapped Cornwallis on the tip of a narrow Virginia peninsula at a place called Yorktown. And so it began. Operating on the belief that Clinton was about to arrive with reinforcements, Cornwallis confidently remained within Yorktown’s inadequate defenses. Determined that nothing short of outright surrender would suffice, his opponent labored day and night to achieve that end. Washington’s brilliance was on display as he skillfully constricted Cornwallis’s position by digging entrenchments, erecting redoubts and artillery batteries, and launching well-timed attacks to capture key enemy positions. The nearly flawless Allied campaign sealed Cornwallis’s fate. Trapped inside crumbling defenses, he surrendered on October 19, 1781, effectively ending the war in North America. Penned by historian Jerome A. Greene, The Guns of Independence: The Siege of Yorktown, 1781 offers a complete and balanced examination of the siege and the participants involved. Greene’s study is based upon extensive archival research and firsthand archaeological investigation of the battlefield. This fresh and invigorating study will satisfy everyone interested in American Revolutionary history, artillery, siege tactics, and brilliant leadership.

March to Victory

March to Victory
Author: Robert Selig
Publisher: U.S. Government Printing Office
Total Pages: 52
Release: 2005
Genre: Biography & Autobiography
ISBN:

Provides an indepth account of the Battle of Yorktown in 1781.