Insights On Antimicrobial Peptides
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Author | : Shymaa Enany |
Publisher | : BoD – Books on Demand |
Total Pages | : 168 |
Release | : 2022-07-06 |
Genre | : Medical |
ISBN | : 183969713X |
Modern medicine is impossible without antibiotics, but global antibiotic usage has led to the development of increasing numbers of multi-drug resistant (MDR) bacteria. Thus, we still have problems with infectious disease treatment despite an arsenal of antibiotics. This has forced researchers to develop new drugs that will be effective against resistant bacteria. Some of these prospective molecules are antimicrobial peptides (AMPs), which are an important component of the innate immune system of various organisms in nature. Currently, more than 3,000 AMPs have been reported with different activities against different bacterial species including resistant phenotype bacteria. AMPs display remarkable structural and functional diversity that is not completely understood. As such, this book presents a comprehensive overview of AMPs and their mechanism of action against MDR bacteria.
Author | : K. Ajesh |
Publisher | : Academic Press |
Total Pages | : 347 |
Release | : 2022-11-23 |
Genre | : Science |
ISBN | : 0323903207 |
Antimicrobial Peptides: Challenges and Future Perspectives covers the latest developments about antimicrobial peptides in the scenario of drug resistance. The book is divided into 16 chapters arranged in sequence and preceded by chapters on historical developments and their role as regulatory molecules in innate defense mechanism. Emphasis is given to purification techniques and characterization suitable for interdisciplinary research. Chapters provide an inventory of various antimicrobial peptides, from a diverse array of organisms such as bacteria, fungi, insects, amphibians, plants and mammals. A section on marine ecosystem broadens readers understanding on marine based antimicrobial peptides. Additional sections provide an informative overview on peptides with antiviral properties and those targeting multi-drug resistant bacteria. Recent reports and mechanism on resistance against antimicrobial peptides are also provided, along with key insights into the challenges and future perspectives of peptide drug development. - Emphasizes antimicrobial peptides targeting various human viruses and multidrug resistant bacteria - Written by internationally recognized experts who provide readers with a wide and useful perspective - Provides in-depth resources for undertaking a research work in antimicrobial peptides with the inclusion of chapters on purification techniques and structural details - Addresses the possibility and availability of peptide antibiotics in the global drug market - Serves as a complete resource from the discovery to drug development of peptide antibiotics
Author | : Evan Floyd Haney |
Publisher | : |
Total Pages | : |
Release | : 2013 |
Genre | : |
ISBN | : 9780494835289 |
Author | : Rustam Aminov |
Publisher | : Frontiers Media SA |
Total Pages | : 185 |
Release | : 2022-11-16 |
Genre | : Science |
ISBN | : 2832505961 |
Author | : Guangshun Wang |
Publisher | : Cabi |
Total Pages | : 0 |
Release | : 2017 |
Genre | : Medical |
ISBN | : 9781786390400 |
This book contains 14 chapters focusing on discovery, classification and functional diversity of antimicrobial peptides; structural and functional diversity of cathelicidins; disulfide-linked defensins; prediction and design of antimicrobial peptides - methods and applications to genomes and proteomes; antimicrobial peptides; microbial membranes and the action of antimicrobial peptides; structural insight into the mechanisms of action of antimicrobial peptides and structure-based design; synergy of antimicrobial peptides; surface immobilization of antimicrobial peptides to prevent biofilm formation; sustained delivery of cathelicidin antimicrobial peptide-inducing compounds to minimize infection and enhance wound healing.
Author | : Richard M. Epand |
Publisher | : Springer |
Total Pages | : 323 |
Release | : 2016-05-06 |
Genre | : Science |
ISBN | : 3319329499 |
This book offers an overview of our current understanding of host defense peptides and their potential for clinical applications as well as some of the obstacles to this. The chapters, written by leading experts in the field, detail the number and diversity of host defense peptides, and discuss the therapeutic potential not only of antibacterial, but also of antifungal, antiviral, plant antimicrobial and anticancer host defense peptides. The authors provide new insights into their mechanisms of action and their immunomodulatory properties, and review recent advances in the design of novel therapeutic molecules. Lastly, their potential to prevent preterm births and Staphylococcus aureus infections is highlighted. The book is of interest to researchers, industry and clinicians alike.
Author | : Shruti Padhee |
Publisher | : |
Total Pages | : |
Release | : 2014 |
Genre | : |
ISBN | : |
The emergent resistance of bacteria against the conventional antibiotics has motivated the search for novel antimicrobial agents. Nature abounds with a number of antimicrobial peptides that are a part of our innate immune system and protect us against a variety of pathogenic bacteria. While they are broad-spectrum in their activity and show less drug-resistance induction, their intrinsic metabolic stability limits their potential therapeutic applications. Herein we describe the development of novel broad-spectrum bioactive antimicrobial peptidomimetics AA-peptides. AApeptides were designed based on chiral PNA backbone. Substitution of nucleobases yields AApeptides that are resistant to proteolysis and capable of mimicking peptides. Two types of AApeptides are discussed in this dissertation "á-AApeptides" and " ã-AApeptides" The therapeutic potential of these AApeptides were accessed by conducting antibacterial assays against a series of both gram-positive, gram-negative bacteria and fungi. These oligomers were characterized using MALDI-TOF and Circular Dichroism spectroscopy (CD). Their invitro toxicity was evaluated against human erythrocytes .We attempted to study their mechanism of action via membrane depolarization assay. We have successfully identified them as antimicrobial agents, pro-inflammatory immune response suppressing agents and as anti-biofilm agents.
Author | : David A. Phoenix |
Publisher | : John Wiley & Sons |
Total Pages | : 0 |
Release | : 2013-04-01 |
Genre | : Science |
ISBN | : 9783527332632 |
In this text, the small team of expert authors presents the field in a comprehensive and accessible manner that is well suited for students and junior researchers. The result is a highly readable and systematically structured introduction to antimicrobial peptides, their structure, biological function and mode of action. The authors point the way towards a rational design of this potentially highly effective new class of clinical antibiotics on the brink of industrial application. They do this by discussing their design principles, target membranes and structure-activity relationships. The final part of the book describes recent successes in the application of peptides as anticancer agents.
Author | : Subhasree Ray |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2024-08-04 |
Genre | : Science |
ISBN | : 9789819734122 |
Antimicrobial peptides (AMPs) have been sought to be a potential alternative to the current arsenal of antibiotics against undesirable microbes. AMPs synthesized by lactic acid bacteria have attracted significant attention due to their strong activity against a broad range of bacteria including pathogens. The bacteriocin (an AMP) has been known to us since early 1928, a year before penicillin was reported. This is possibly due to their narrower activity compared to antibiotics. However, several AMPs having promising activity have been thoroughly characterized in the past few decades. Renewed interest has developed focusing on industrially important bacteriocins produced by lactic acid bacteria. Some of these AMPs are also active against food spoilage and clinically important pathogens. Similar to antibiotics, large-scale intellectual screening is ongoing in the search for novel AMPs with unique properties. Recent research has revealed that AMPs may also play a role in maintaining gut microflora and keeping us protected from food-borne pathogens. The ongoing genomic studies suggest that there may be more such bioactive compounds waiting to be explored. This book provides an overview of the fundamental knowledge accumulated so far regarding the diversity and potential applications of AMPs produced by lactic acid bacteria. This updated reference book on AMPs from lactic acid bacteria is timely, covering the most important achievements in the field and providing the scientific community particularly graduate students, researchers, and clinicians with the latest updates. The goal of this book is to illustrate and detail the findings made so far, debate the state of the art, and draw new perspectives.
Author | : Thomas J. Dougherty |
Publisher | : Springer Science & Business Media |
Total Pages | : 1119 |
Release | : 2011-12-18 |
Genre | : Medical |
ISBN | : 1461414008 |
This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.