Insights in autoimmune and autoinflammatory disorders: 2021
Author | : Betty Diamond |
Publisher | : Frontiers Media SA |
Total Pages | : 140 |
Release | : 2023-03-14 |
Genre | : Medical |
ISBN | : 283250048X |
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Author | : Betty Diamond |
Publisher | : Frontiers Media SA |
Total Pages | : 140 |
Release | : 2023-03-14 |
Genre | : Medical |
ISBN | : 283250048X |
Author | : Ralf J. Ludwig |
Publisher | : Frontiers Media SA |
Total Pages | : 754 |
Release | : 2021-05-25 |
Genre | : Medical |
ISBN | : 2889668096 |
Author | : Shailendra K. Saxena |
Publisher | : BoD – Books on Demand |
Total Pages | : 416 |
Release | : 2021-08-25 |
Genre | : Medical |
ISBN | : 1838807659 |
The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.
Author | : Tomohiro Kurosaki |
Publisher | : Springer |
Total Pages | : 233 |
Release | : 2015-12-26 |
Genre | : Medical |
ISBN | : 3319261339 |
This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
Author | : Asghar Aghamohammadi |
Publisher | : Academic Press |
Total Pages | : 396 |
Release | : 2021-01-22 |
Genre | : Medical |
ISBN | : 0128231890 |
Awareness among clinicians about PIDs, which consist of more than 400 different entities, plays an important role in ensuring that patients receive a timely diagnosis. Furthermore, clinicians who are educated about PIDs can give their patients access to optimal management of their condition, thus helping the patient achieve a better quality-of-life and long-term prognosis. Inborn Errors of Immunity: A Practical Guide provides the most up-to-date information for busy students, nurses, clinical residents, practicing physicians, and even basic researchers. Readers will benefit from a well-structured breakdown of complicated PID diseases, including approaches to their clinical signs/symptoms and immunologic/laboratory findings. - Presents valuable contribution of more than 40 expert chapter authors, from top centers spanning five continents, each in a specific PID field - Covers various aspects of PID using updated clinical guidelines and standard stepwise pipelines - Focuses on the latest developments in the molecular diagnosis and pathogenesis of diseases, with easy explanation and schematic representation of defective signaling pathways - Includes dedicated sections for clinical features and immunological tests with carefully-curated figures of PID manifestations, imaging, and histological/pathological illustrations to create the first PID medial-color atlas - Summarizes the updated conventional and specific treatments and follow-up notes for different PID diseases
Author | : Zahava Vadasz |
Publisher | : Frontiers Media SA |
Total Pages | : 308 |
Release | : 2022-09-19 |
Genre | : Medical |
ISBN | : 2889769984 |
Author | : Raphaela Goldbach-Mansky |
Publisher | : Frontiers Media SA |
Total Pages | : 173 |
Release | : 2023-03-31 |
Genre | : Medical |
ISBN | : 2832519385 |
Author | : Philip J. Hashkes |
Publisher | : Springer |
Total Pages | : 793 |
Release | : 2019-02-13 |
Genre | : Medical |
ISBN | : 3319986058 |
This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.
Author | : P. E. Bigazzi |
Publisher | : CRC Press |
Total Pages | : 328 |
Release | : 1991-08-30 |
Genre | : Medical |
ISBN | : 9780824785505 |
Surveys the biotechnologically influenced advances in the understanding of systemic autoimmune disorders, highlighting recent research using cell biology and biochemistry, the cloning of immune cells, recombinant DNA, and molecular genetics. Among the topics are the role of complement in inflammatio