Induced Pluripotent Stem Cells
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| Author | : Sibel Yildirim |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 76 |
| Release | : 2012-02-02 |
| Genre | : Science |
| ISBN | : 146142206X |
Induced Pluripotent Stem (iPS) cells are mature cells that have been genetically reprogrammed so that they return to their embryonic state. It is not yet known if iPS stem cells and embryonic stem cells differ significantly. Today many fundamental belief systems in biology are shifting towards accepting that mature body cells can be reverted to an embryonic state without the help of eggs or embryos. With their changed identities, iPS cells are then ready to serve as new tools for research in the fields of disease pathogenesis, drug discovery, oncology, and cell transplantation. One example of this would be using iPS from a patient’s mature cells to repair damaged tissue; it is thought that there would be very low incidence of rejection of the ‘new’ tissue in these cases. For the last four years, this therapeutic promise has been studied by hundreds of researchers worldwide in an effort to understand the ability of these cells to reverse their biological clocks.
| Author | : Hans Spemann |
| Publisher | : |
| Total Pages | : 424 |
| Release | : 1962 |
| Genre | : Embryology |
| ISBN | : |
| Author | : Michael S. Goligorsky |
| Publisher | : Academic Press |
| Total Pages | : 473 |
| Release | : 2010-11-26 |
| Genre | : Science |
| ISBN | : 0123809290 |
Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. - Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers - Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney
| Author | : Michal Amit |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 151 |
| Release | : 2011-11-19 |
| Genre | : Science |
| ISBN | : 1617795488 |
Human pluripotent stem cells, including human embryonic stem cells and induced pluripotent stem cells, are a key focus of current biomedical research. The emergence of state of the art culturing techniques is promoting the realization of the full potential of pluripotent stem cells in basic and translational research and in cell-based therapies. This comprehensive and authoritative atlas summarizes more than a decade of experience accumulated by a leading research team in this field. Hands-on step-by-step guidance for the derivation and culturing of human pluripotent stem cells in defined conditions (animal product-free, serum-free, feeder-free) and in non-adhesion suspension culture are provided, as well as methods for examining pluripotency (embryoid body and teratoma formation) and karyotype stability. The Atlas of Human Pluripotent Stem Cells - Derivation and Culturing will serve as a reference and guide to established researchers and those wishing to enter the promising field of pluripotent stem cells.
| Author | : Trygve Tollefsbol |
| Publisher | : Academic Press |
| Total Pages | : 617 |
| Release | : 2012-07-26 |
| Genre | : Medical |
| ISBN | : 0123884160 |
Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs
| Author | : Arlene Chiu |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 488 |
| Release | : 2003-08 |
| Genre | : Science |
| ISBN | : |
A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property.
| Author | : Carlos Simón |
| Publisher | : Cambridge University Press |
| Total Pages | : 199 |
| Release | : 2013-07-04 |
| Genre | : Medical |
| ISBN | : 1107034477 |
Stem cell science has the potential to impact human reproductive medicine significantly - cutting edge technologies allow the production and regeneration of viable gametes from human stem cells offering potential to preciously infertile patients. Written by leading experts in the field Stem Cells in Reproductive Medicine brings together chapters on the genetics and epigenetics of both the male and female gametes as well as advice on the production and regeneration of gene cells in men and women, trophoblasts and endometrium from human embryonic and adult stem cells. Although focussing mainly on the practical elements of the use of stem cells in reproductive medicine, the book also contains a section on new developments in stem cell research. The book is essential reading for reproductive medicine clinicians, gynecologists and embryologists who want to keep abreast of practical developments in this rapidly developing field.
| Author | : Toshio Nakanishi |
| Publisher | : Springer Nature |
| Total Pages | : 374 |
| Release | : 2020-02-28 |
| Genre | : Medical |
| ISBN | : 9811511853 |
This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.
| Author | : Alexander Birbrair |
| Publisher | : Academic Press |
| Total Pages | : 274 |
| Release | : 2020-09-29 |
| Genre | : Science |
| ISBN | : 0323851851 |
The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs from Diverse Species, Volume 2 addresses how induced pluripotent stem cells (iPSCs) can be derived from different species. The volume teaches the reader about modern state-of-the-art methodologies to derive iPSCs from distinct species. This volume will cover how to derive iPSCs from species like nonhuman primates, horses, dogs, pigs, rats, rabbits, and others. It also discusses the importance of iPSCs in species conservation. Detailed description on methods used to obtain iPSCs from humans and other species expands the knowledge and understanding of stem cell biology and provides a potent tool to model diseases. The volume is written for researchers and scientists in stem cell biology, and regenerative medicine and is contributed by world-renowned authors in the field. - Provides overview of the fast-moving field of iPSC technology - Covers iPCSs from the following species: humans, monkeys, horses, dogs, pigs, rats, rabbits, and more - Consists of contributions from stem cell leaders around the world
| Author | : Philip H. Schwartz |
| Publisher | : Humana Press |
| Total Pages | : 468 |
| Release | : 2011-08-09 |
| Genre | : Science |
| ISBN | : 9781617792007 |
Almost daily, new technologies are being presented that move the field of human pluripotent stem cell research towards a future that may yield highly-effective, personalized medical treatments. Three enabling technologies at hand for human PSCs are 1) directed reprogramming of somatic cells, which eliminate many of the ethical issues associated with the derivation and use of human PSCs, increase genetic diversity of the available human PSC lines, and give rise to better in vitro human disease models; 2) the discovery that a Rho-associated protein Kinase (ROCK) inhibitor allows for efficient single cell passaging and cryopreservation, increasing the efficiency and reliability of hPSC culture; and 3) defined, animal-component-free media, which lay the groundwork for simplified scale-up for therapeutic applications, differentiation protocols, and toxicology screens. The aforementioned technologies can be found in Human Pluripotent Stem Cells: Methods and Protocols, a compilation of 33 detailed protocols in six categories of PSC research that cover laboratory essentials and the derivation of new PSC lines, including induced PSC lines, as well as their growth, maintenance, characterization, genetic manipulation, and differentiation. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Human Pluripotent Stem Cells: Methods and Protocols serves as an ideal guide to scientists conducting their own pluripotent cell research programs and makes great strides towards furthering human knowledge and, ultimately, improving the human condition.
