Abnormal Embryogenesis

Abnormal Embryogenesis
Author: T.V.N. Persaud
Publisher: Springer Science & Business Media
Total Pages: 249
Release: 2012-12-06
Genre: Science
ISBN: 9401166544

The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intrauterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mechanisms, and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. The comributions in this volume include some of the more recent and exciting observations on the cellular and molecular aspects of developmental defects. It is not only a documentation of the latest experimental work, but it also indicates new and important areas for future research.

Cell Lineage and Embryo Patterning

Cell Lineage and Embryo Patterning
Author:
Publisher: Elsevier
Total Pages: 643
Release: 2000-12-13
Genre: Science
ISBN: 008048915X

International Review of Cytology presents current advances and comprehensive reviews in cell biology, both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.This volume brings together current information on the localization and roles of RNAs in cell-lineage determination and subsequent patterning in embryonic development. Guest co-editor Lawrence Etkin is one of the leading researchers in molecular genetics of Xenopus.Key Features* A number of important concepts are discussed, including:* How polarity is established during oogenesis* How germ cell determinants become organized in the establishment of the germ cell lineage* Different strategies used by organisms to establish the germ cell lineage* Similarities and differences between the mechanisms used in embryonic patterning* The mechanisms and machinery by which molecules such as RNA become asymmetrically segregated* The use of similar signaling pathways in patterning of the dorsal-ventral and right-left asymmetries, embryonic germ layers, limb, and nervous system* The link between fundamental biological processes such as RNA translation and localization in the regulation of axis specification

IBZ

IBZ
Author:
Publisher:
Total Pages: 1288
Release: 1981
Genre: Periodicals
ISBN:

Embryogenesis in Mammals

Embryogenesis in Mammals
Author: Katherine Elliott
Publisher: John Wiley & Sons
Total Pages: 192
Release: 2009-09-16
Genre: Science
ISBN: 0470717904

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.