Computational Epigenetics and Diseases

Computational Epigenetics and Diseases
Author:
Publisher: Academic Press
Total Pages: 452
Release: 2019-02-06
Genre: Medical
ISBN: 0128145145
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Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. - Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases - Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA - Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Activity-Based Protein Profiling

Activity-Based Protein Profiling
Author: Benjamin F. Cravatt
Publisher: Springer
Total Pages: 420
Release: 2019-01-25
Genre: Medical
ISBN: 3030111431
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This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.

Plant Small RNA

Plant Small RNA
Author: Praveen Guleria
Publisher: Academic Press
Total Pages: 638
Release: 2020-02-19
Genre: Science
ISBN: 012817336X
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Plant Small RNA: Biogenesis, Regulation and Application describes the biosynthesis of small RNA in plant systems. With an emphasis on the various molecular mechanisms affected by small RNA and their applications in supporting plant growth and survival, this books presents the basics and most recent advancements in small RNA mediated plant genomics, metabolomics, proteomics and physiology. In addition, it emphasizes the various molecular mechanisms affected by small RNA and their applications in supporting plant growth and survival. Final sections cover the most recent advancements in small RNA mediated plant genomics, metabolomics, proteomics and physiology. - Presents foundational information about small RNA biology and regulation in plants - Includes small RNA pathway advances - Describes the application and scope of small RNA technology for agricultural stability

Clinical Bioinformatics

Clinical Bioinformatics
Author: Ronald Trent
Publisher: Humana
Total Pages: 0
Release: 2016-08-23
Genre: Science
ISBN: 9781493947003
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In Clinical Bioinformatics, Second Edition, leading experts in the field provide a series of articles focusing on software applications used to translate information into outcomes of clinical relevance. Recent developments in omics, such as increasingly sophisticated analytic platforms allowing changes in diagnostic strategies from the traditional focus on single or small number of analytes to what might be possible when large numbers or all analytes are measured, are now impacting patient care. Covering such topics as gene discovery, gene function (microarrays), DNA sequencing, online approaches and resources, and informatics in clinical practice, this volume concisely yet thoroughly explores this cutting-edge subject. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Clinical Bioinformatics, Second Edition serves as an ideal guide for scientists and health professionals working in genetics and genomics.

Integration of Omics Approaches and Systems Biology for Clinical Applications

Integration of Omics Approaches and Systems Biology for Clinical Applications
Author: Antonia Vlahou
Publisher: John Wiley & Sons
Total Pages: 386
Release: 2018-02-21
Genre: Science
ISBN: 1119181143
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Introduces readers to the state of the art of omics platforms and all aspects of omics approaches for clinical applications This book presents different high throughput omics platforms used to analyze tissue, plasma, and urine. The reader is introduced to state of the art analytical approaches (sample preparation and instrumentation) related to proteomics, peptidomics, transcriptomics, and metabolomics. In addition, the book highlights innovative approaches using bioinformatics, urine miRNAs, and MALDI tissue imaging in the context of clinical applications. Particular emphasis is put on integration of data generated from these different platforms in order to uncover the molecular landscape of diseases. The relevance of each approach to the clinical setting is explained and future applications for patient monitoring or treatment are discussed. Integration of omics Approaches and Systems Biology for Clinical Applications presents an overview of state of the art omics techniques. These methods are employed in order to obtain the comprehensive molecular profile of biological specimens. In addition, computational tools are used for organizing and integrating these multi-source data towards developing molecular models that reflect the pathophysiology of diseases. Investigation of chronic kidney disease (CKD) and bladder cancer are used as test cases. These represent multi-factorial, highly heterogeneous diseases, and are among the most significant health issues in developed countries with a rapidly aging population. The book presents novel insights on CKD and bladder cancer obtained by omics data integration as an example of the application of systems biology in the clinical setting. Describes a range of state of the art omics analytical platforms Covers all aspects of the systems biology approach—from sample preparation to data integration and bioinformatics analysis Contains specific examples of omics methods applied in the investigation of human diseases (Chronic Kidney Disease, Bladder Cancer) Integration of omics Approaches and Systems Biology for Clinical Applications will appeal to a wide spectrum of scientists including biologists, biotechnologists, biochemists, biophysicists, and bioinformaticians working on the different molecular platforms. It is also an excellent text for students interested in these fields.

Water Stress and Crop Plants

Water Stress and Crop Plants
Author: Parvaiz Ahmad
Publisher: John Wiley & Sons
Total Pages: 784
Release: 2016-06-08
Genre: Science
ISBN: 1119054478
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Plants are subjected to a variety of abiotic stresses such as drought, temperature, salinity, air pollution, heavy metals, UV radiations, etc. To survive under these harsh conditions plants are equipped with different resistance mechanisms which vary from species to species. Due to the environmental fluctuations agricultural and horticultural crops are often exposed to different environmental stresses leading to decreased yield and problems in the growth and development of the crops. Drought stress has been found to decrease the yield to an alarming rate of some important crops throughout the globe. During last few decades, lots of physiological and molecular works have been conducted under water stress in crop plants. Water Stress and Crop Plants: A Sustainable Approach presents an up-to-date in-depth coverage of drought and flooding stress in plants, including the types, causes and consequences on plant growth and development. It discusses the physiobiochemical, molecular and omic approaches, and responses of crop plants towards water stress. Topics include nutritional stress, oxidative stress, hormonal regulation, transgenic approaches, mitigation of water stress, approaches to sustainability, and modern tools and techniques to alleviate the water stress on crop yields. This practical book offers pragmatic guidance for scientists and researchers in plant biology, and agribusinesses and biotechnology companies dealing with agronomy and environment, to mitigate the negative effects of stress and improve yield under stress. The broad coverage also makes this a valuable guide enabling students to understand the physiological, biochemical, and molecular mechanisms of environmental stress in plants.

Intelligent Computing Theories and Application

Intelligent Computing Theories and Application
Author: De-Shuang Huang
Publisher: Springer Nature
Total Pages: 638
Release: 2020-10-13
Genre: Computers
ISBN: 3030608026
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This two-volume set of LNCS 12463 and LNCS 12464 constitutes - in conjunction with the volume LNAI 12465 - the refereed proceedings of the 16th International Conference on Intelligent Computing, ICIC 2020, held in Bari, Italy, in October 2020. The 162 full papers of the three proceedings volumes were carefully reviewed and selected from 457 submissions. The ICIC theme unifies the picture of contemporary intelligent computing techniques as an integral concept that highlights the trends in advanced computational intelligence and bridges theoretical research with applications. The theme for this conference is “Advanced Intelligent Computing Methodologies and Applications.” Papers related to this theme are especially solicited, addressing theories, methodologies, and applications in science and technology.

MicroRNAs

MicroRNAs
Author: Krishnarao Appasani
Publisher: Cambridge University Press
Total Pages: 580
Release: 2009-08-20
Genre: Science
ISBN: 9780521118552
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MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their recent discovery is revolutionising both basic biomedical research and drug discovery. Expression levels of MiRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in R&D in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology, this volume uniquely integrates the basic science with industry application towards drug validation, diagnostic and therapeutic development. Forewords by: Sidney Altman, Yale University, Winner of the Nobel Prize in Chemistry, 1989 and Victor R. Ambros, Dartmouth Medical School, Co-discoverer of MicroRNAs

Plant MicroRNAs

Plant MicroRNAs
Author: Stefan de Folter
Publisher: Humana Press
Total Pages: 363
Release: 2019-01-31
Genre: Science
ISBN: 9781493990412
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This detailed volume provides a collection of protocols for the study of miRNA functions in plants. Beginning with coverage of miRNA function, biogenesis, activity, and evolution in plants, the book continues by guiding readers through methods on the identification and detection of plant miRNAs, bioinformatic analyses, and strategies for functional analyses of miRNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Plant MicroRNAs: Method and Protocols aims to ensure successful results in the further study of this vital area of plant science.

The Tomato Genome

The Tomato Genome
Author: Mathilde Causse
Publisher: Springer
Total Pages: 260
Release: 2016-11-21
Genre: Science
ISBN: 3662533898
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This book describes the strategy used for sequencing, assembling and annotating the tomato genome and presents the main characteristics of this sequence with a special focus on repeated sequences and the ancestral polyploidy events. It also includes the chloroplast and mitochondrial genomes. Tomato (Solanum lycopersicum) is a major crop plant as well as a model for fruit development, and the availability of the genome sequence has completely changed the paradigm of the species’ genetics and genomics. The book describes the numerous genetic and genomic resources available, the identified genes and quantitative trait locus (QTL) identified, as well as the strong synteny across Solanaceae species. Lastly, it discusses the consequences of the availability of a high-quality genome sequence of the cultivated species for the research community. It is a valuable resource for students and researchers interested in the genetics and genomics of tomato and Solanaceae.