This book constitutes the thoroughly refereed post-conference proceedings of the 22nd International Symposium on Implementation and Applications of Functional Languages, IFL 2010, held in Alphen aan den Rijn, The Netherlands, in September 2010. The 13 revised full papers presented were carefully reviewed and were selected from 31 submissions. The IFL symposia bring together researchers and practitioners that are actively engaged in the implementation and the use of functional and function based programming languages. Every year IFL provides a venue for the presentation and discussion of new ideas and concepts, of work in progress, and of publication-ripe results.