Immunopharmacology Of Joints And Connective Tissues
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| Author | : Clive P. Page |
| Publisher | : Elsevier |
| Total Pages | : 296 |
| Release | : 1994-03-07 |
| Genre | : Medical |
| ISBN | : 9780122063459 |
The consequences for diseases involving the immune system such as AIDS, and chronic inflammatory diseases such as bronchial asthma, rheumatoid athritis, and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases, and a tremendous drive to identify novel therapeutic applications for their preventions and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drug development. As a consequence, this area has not gained the prominence of other new fields such as molecular pharmacology or neuropharmacology, and a focal information source for many pharmacologists interested in diseases of the immune system remains unpublished. The Handbook of Immunopharmacology series provides such a source through the commissioning of a comprehensive collection of volumes on all aspects immunopharmacology. Editors have been sought after for each volume who are not only active in their respective areas of expertise, but who also have distinctly pharmacological bias to their research. The series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types and classes of inflammatory responses that can affect them ("Systems"). The third covers different classes of diseases as well as those under development ("Drugs").
| Author | : Manzoor M. Khan |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 275 |
| Release | : 2008-12-19 |
| Genre | : Medical |
| ISBN | : 0387779760 |
During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.
| Author | : Josef S. Smolen |
| Publisher | : CRC Press |
| Total Pages | : 636 |
| Release | : 2007-10-18 |
| Genre | : Medical |
| ISBN | : 0203694147 |
Targeted therapies of rheumatic diseases have become a reality and have completely changed patient care as well as patient expectations. Initial success with therapies aimed at blocking TNF and IL-1 has stimulated the development of additional targeted approaches focused on other cytokines as well as specific cells and pathways involved in the path
| Author | : |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 797 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1461564999 |
Arthritis and its related musculoskeletal disorders constitute the most common chronic illnesses in the United States. These conditions adversely affect the quality of life of those who are struck by them, require increased use of health care resources, and, because they are the leading cause of disability in the United States, have a significant impact on the national economy. Physicians and other health care workers in many disciplines have been involved in the care and study of patients with these diseases. As a result, our understanding of and ability to treat these diseases have improved continuously. This Atlas of Rheumatology is designed to help clinicians learn about this group of diseases and develop an understanding of their possible causes, clinical features, laboratory findings, and treatments, using an attractive pictorial format. Because more than 100 sepa rate types of arthritis have been described, unfortunately all could not be included. The illus trations shown in the Atlas have been carefully selected by recognized experts, who served as authors of the eight chapters, to provide the reader with the essential information needed to get a clear picture of these important diseases. For their successful efforts I am deeply grateful. I am also indebted to editorial workers who have maintained high standards to create a clear, attractive final product.
| Author | : K. D. Rainsford |
| Publisher | : John Wiley & Sons |
| Total Pages | : 620 |
| Release | : 2015-09-08 |
| Genre | : Medical |
| ISBN | : 1118743385 |
Ibuprofen has become one of the foremost pain-relieving medications world-wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non-pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered. Edited by leading world expert with over 40 years record in research, teaching and as a scientific advisor in the field of anti-inflammatory/analgesic agents. Professor Kim Rainsford is also the founding Editor-in-Chief of the journal, Inflammopharmacology, as well as being an Associate Editor of The Journal of Pharmacy & Pharmacology. Provides a thorough coverage of the medicinal chemistry and pharmaceutics of ibuprofen, and its pharmacokinetics in both humans and animals. Includes molecular, pharmacological and toxicological studies, and discusses the safety and efficacy of non-prescription ibuprofen, including its side effects. Ibuprofen: Discovery, Development & Therapeutics provides a definitive reference on all the main aspects of the chemical and pharmaceutical properties, mechanisms of action and therapeutic uses of ibuprofen including its role in the prevention and treatment of rheumatic conditions, cancer and neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases. The book has its origins in a volume first published in 1999, since when there have been considerable advances in research and clinical studies on ibuprofen in the treatment of many inflammatory and even non-inflammatory states. This book will prove invaluable to scientists, clinicians, pharmacists and all those who need to know about the actions and uses of anti-inflammatory and analgesic drugs.
| Author | : Kim D. Rainsford |
| Publisher | : CRC Press |
| Total Pages | : 571 |
| Release | : 2003-09-02 |
| Genre | : Medical |
| ISBN | : 0203362586 |
Ibuprofen is widely used throughout the world for a variety of conditions. This reference work provides a comprehensive and critical review of the basic science and clinical aspects of the drug. The book begins with the history and development of the drug and its current patterns of use world- wide before moving on to examine its basic pharmaceutical attributes and medicinal chemistry. The properties of various formulations are described (oral prescription and OTC, topical and others) are described. The pharmacokinetics of ibuprofen in animals and humans is discussed - highlighting the factors affecting absorption, distribution, metabolism and elimination. The clinical pharmacology and toxicology and the drug's mechanisms of action in different disease states and conditions are covered. The therapeutic uses in various acute and inflammatory conditions is detailed. Also considered are the safety versus efficacy issues and the pharmacoepidemiological data.
| Author | : |
| Publisher | : |
| Total Pages | : 138 |
| Release | : 1997-02 |
| Genre | : |
| ISBN | : |
| Author | : A. Stallmach |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 350 |
| Release | : 1998-12-31 |
| Genre | : Medical |
| ISBN | : 9780792387473 |
This book, the proceedings of Falk Symposium No. 104, organized in collaboration with the Society of Mucosal Immunology, and held in Saarbrucken, Germany, March 5-7 1998, is centered around the immunological mechanisms of mucosal protection and their disturbances leading to intestinal inflammation and destruction. This is a rapidly expanding field involving recent knowledge of basic immunology and cell biology as well as clinical observations. The conference and this book summarize very recent data in this field and suggest strategies for future research and clinical applications, and will be of interest to both basic scientists and clinicians.
| Author | : Stephen T. Holgate |
| Publisher | : Elsevier |
| Total Pages | : 286 |
| Release | : 1995-10-18 |
| Genre | : Medical |
| ISBN | : 0080534554 |
Immunopharmacology represents the boundary between the immune system and chemical mediators of the inflammatory and neuroendocrine responses. The subject as applied to the respiratory system embraces most of the common non-malignant lung diseases of which asthma and allied disorders are the most prevalent. An understanding of the underlying mechanisms of the disorders provides rationale for prevention and drug treatment as well as creating opportunities for novel drug development. Immunopharmacology of Respiratory System embraces all of these principles and should enable the reader to become rapidly updated in an area of medical importance. - Focuses on aspects of disease pathogenesis that are common to a variety of lung disorders - Includes coverage of the mechanisms of asthma - origin, progression, and novel therapeutic interventions - This volume is another in the "Systems" section of the Handbook of Immunopharmacology
| Author | : Nikos C. Apostolopoulos |
| Publisher | : Springer |
| Total Pages | : 239 |
| Release | : 2018-12-27 |
| Genre | : Science |
| ISBN | : 3319968009 |
In this manuscript, practitioners and students who are concerned with sports and rehabilitation medicine, kinesiology, as well as coaches and athletes, are introduced to numerous concepts, including mechanotransduction, inflammation, pro- and anti-inflammatory cytokines, calpains, the extracellular matrix, neutrophils and macrophages, and their relevance to stretching, particularly stretching intensity. Although the quantitative parameters of training, duration, and frequency are important, it is the qualitative criterion of intensity (“how much”) that the author suggests is ultimately of greater concern. Intensity, the rate and magnitude of force, may be responsible for the proper recovery, regeneration, and adaptation of the musculoskeletal tissues from training, competition, or rehabilitation from injuries. Research suggests that too much force results in the stimulation of an inflammatory response, one associated with a biochemical feedback emerging from a mechanical stimulus. The intent of this manuscript is twofold: to initiate the discussion of the importance of stretching intensity with regard to proper recovery, regeneration, and adaptation, and to suggest that researchers need to explore its potential role in addressing numerous inflammatory (RA) and non-inflammatory (OA, recurrent tendinitis etc.) musculoskeletal conditions as well.
