Immunomodulation
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| Author | : Stephen F. Badylak |
| Publisher | : Woodhead Publishing |
| Total Pages | : 296 |
| Release | : 2021-07-30 |
| Genre | : Technology & Engineering |
| ISBN | : 0128214562 |
Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an "inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. - Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response - Provides a single reference for understanding and utilizing the host response in biomaterials design - An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 102 |
| Release | : 2006-01-03 |
| Genre | : Medical |
| ISBN | : 0309180686 |
Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.
| Author | : Nihal Engin Vrana |
| Publisher | : CRC Press |
| Total Pages | : 300 |
| Release | : 2018-07-20 |
| Genre | : Medical |
| ISBN | : 1351377558 |
The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area
| Author | : Marschall S. Runge |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 604 |
| Release | : 2007-11-14 |
| Genre | : Medical |
| ISBN | : 1592598781 |
An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system.
| Author | : Bharat B. Aggarwal |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 502 |
| Release | : 2007-08-06 |
| Genre | : Medical |
| ISBN | : 0387464018 |
The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.
| Author | : Diana Boraschi |
| Publisher | : Academic Press |
| Total Pages | : 300 |
| Release | : 2016-01-25 |
| Genre | : Medical |
| ISBN | : 0128033363 |
Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine. Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabolic disorders, etc. - Visits immunosuppression from a modern point of view of signalling mechanisms at the light of the current knowledge of signalling mechanisms and regulatory networks allows the reader to formulate new ideas and concepts on how to use immunosuppression the therapeutic purposes - Encourages researchers to engage into exploring the field of pharmacological modulation of immune responses in depth, and with the new knowledge and tools available, designs more effective therapeutic strategies to autoimmune and inflammatory diseases, cancer, degenerative diseases and infections - Examines the link between molecular pathways associated to immune-suppression and the new immunopharmacology approaches - Provides information on the new strategies for drug development in this field - Considers the role of microbes in the development of the mammalian immune system and immune responses, which will widen the reader's strategy for addressing therapeutic immune modulations
| Author | : Lucy Di Silvio |
| Publisher | : Elsevier |
| Total Pages | : 649 |
| Release | : 2008-12-22 |
| Genre | : Technology & Engineering |
| ISBN | : 184569547X |
The response of cells to biomaterials is critical in medical devices. Traditionally inert biomaterials were used to minimise the reaction in cells in contact with the material. However, it has been realised that specific cell responses may be beneficial in such areas as encouraging adhesion, healing or cell multiplication. Cellular response to biomaterials discusses the response of cells to a wide range of biomaterials targeted at specific medical applications.Part one discusses cell responses to a variety of polymers and ceramics with chapters on such topics as degradable polymers and biocompatibility. Part two covers cell responses and regenerative medicine with coverage of themes such as vascular grafts, nerve repair and Bioglass®. Part three examines the effect of surfaces and proteins on cell response. Specific chapters review nano-engineered surfaces, the influence of plasma proteins on bone cell adhesion and surface modification of titanium implants.With its distinguished editor and team of international contributors, Cellular response to biomaterials is an essential read for those researching or studying medical devices in industry and academia. - Examines the response of cells to a wide range of biomaterials targeted at specific medical applications - Discusses cell responses and regenerative medicine with specific chapters on vascular grafts and nerve repair - Assesses the effect of surfaces and proteins on cell response including the influence of plasma proteins on cell adhesion and surface modification of titanium implants
| Author | : Neelam S. Sangwan |
| Publisher | : Springer Nature |
| Total Pages | : 547 |
| Release | : 2022-08-30 |
| Genre | : Medical |
| ISBN | : 9811681171 |
This book describes the process of immunomodulation and the plants which possess immunomodulation properties to boost the immune system. The immunomodulation process is highly relevant to address emerging as well as existing diseases in humans. A better immune system triggers the cellular responses for neutralizing and combating the onset of disease conditions. Chapters in the book discuss plants that have profound effects on the health and well-being of humans. They discuss the natural phytochemicals that have immense diversity and uniqueness of molecules. Molecules belonging to phenylpropanoids, terpenoids, steroids, alkaloids, and tannins etc possess a variety of pharmacological activities. The chapters describe how bioactive exert effects even when taken as part of the diet, supplement, and or as traditional herbal medicine. This book provides up-to-date scientific knowledge about the activities and mechanisms and leads in the area of medicinal plants and phytochemicals with immunomodulation properties. This book is meant for students, academics, researchers, and industry professionals interested in pharmacology, immunology, and plant secondary metabolites.
| Author | : Rajesh K. Kesharwani |
| Publisher | : CRC Press |
| Total Pages | : 276 |
| Release | : 2023-10-20 |
| Genre | : Medical |
| ISBN | : 1000800296 |
The unique volume, COVID-19 and Immunomodulation with Special Emphasis on Nutraceutical and Herbal Formulation, covers recent advances in the management, prevention, and application of nutraceuticals and herbs in preventing and treating COVID-19. It demonstrates the beneficial immunomodulatory properties of nutraceuticals, spices, polyphenols, customary (traditional) medications, natural products, ayurveda, antioxidants, trace elements, vitamins, vaccines, etc., for COVID-19. Key features: Evaluates the benefits of herbal immunomodulators for safety and having fewer (if any) side effects, as opposed to conventional/artificial drugs Considers the role of ayurvedic medicines in the control and prevention of COVID-19 viruses Summarizes the most current discoveries and key factors of SARS-CoV-2 genetics, pathophysiology, and the host immune response Looks at the efficacy of vaccines against COVID-19 infection and the vaccines currently available Explains the pharmacological results alongside precise immunomodulator agents, like immunostimulators and immunosuppressants Looks at the containment and prevention strategies for COVID-19 infection and offers strategies for the future The information provided here details how the use of selected nutraceuticals and herbals can be helpful, similarly to pharmacological remedies, in stopping some COVID-19-associated complications in infected patients. It will be a valuable resource for researchers in pharmaceutical science, medicine, COVID and related diseases, and others.
| Author | : Catarina R. Almeida |
| Publisher | : Frontiers Media SA |
| Total Pages | : 204 |
| Release | : 2020-03-23 |
| Genre | : |
| ISBN | : 2889635740 |
