Immunobiology Of Natural Killer Cell Receptors
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| Author | : Eric Vivier |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 209 |
| Release | : 2005-12-20 |
| Genre | : Medical |
| ISBN | : 3540277439 |
Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.
| Author | : Jacques Zimmer |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 425 |
| Release | : 2010-01-12 |
| Genre | : Medical |
| ISBN | : 3642023096 |
Natural killer (NK) cells have been at the forefront of immunology for two decades. During that time, a great amount of information about these cells has been obtained. They are important in antiinfectious and antitumoral defense and shape the adaptive immune response. In addition, they can act as immunoregulatory cells. In recent years, the therapeutic potential of NK cells in cancer immunotherapy has become increasingly evident. This book describes in detail current knowledge about NK cells and covers a broad range of NK cell-related topics, including those that are not frequently reviewed, e.g. NK cells and allergy or NK cells and skin diseases.
| Author | : Eric Vivier |
| Publisher | : Springer |
| Total Pages | : 284 |
| Release | : 2005-10-20 |
| Genre | : Medical |
| ISBN | : 9783540260837 |
Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.
| Author | : Benjamin Bonavida |
| Publisher | : Academic Press |
| Total Pages | : 540 |
| Release | : 2021-06-23 |
| Genre | : Science |
| ISBN | : 0128243961 |
Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the unique therapeutic applications of NK cells to fight cancers and eliminate the bulk and subset of cancer stem cells responsible for metastasis, relapse and recurrences. The book provides information on the development, engineering, mechanisms of action, response to various preclinical models, and applications in various clinical trials. Sections cover the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application of CAR-NK cells, and new NK-drug conjugates, also emphasizing that activated NK cells can target and kill highly resistant cancer stem cells. Written by the leading experts on NK immunotherapy worldwide, this is a valuable resource for researchers, clinicians and members of the biomedical field who are interested in understanding novel and efficient therapies to fight cancers. Discusses the unique developmental applications of NK immunotherapy against cancers, which differs greatly from other types of immunotherapies Provides up-to-date and highly relevant information through chapters written by the leading researchers in the field Presents a significant number of schematic diagrams for easy understanding and reproducibility
| Author | : Colton Williams |
| Publisher | : States Academic Press |
| Total Pages | : 247 |
| Release | : 2021-11-16 |
| Genre | : Science |
| ISBN | : 9781639893850 |
NK cells, or natural killer cells belong to the group of innate lymphoid cells which are vital to the innate immune system. They are a type of cytotoxic lymphocytes. NK cells respond rapidly to virus infected cell and other intracellular pathogens. They also take action against the formation of tumors. There are different NK cell receptors which have different functions. They can directly cause cell death after binding themselves to Fas ligand which shows infection of a cell. The MHC-independent receptors use a different pathway to cause apoptosis in infected cells. The activation of NK cells depends on the balance of activating and inhibitory receptor stimulation. This book unfolds the innovative aspects of NK cell receptors, which will be crucial for the progress of this field in the future. It consists of contributions made by international experts. The book is appropriate for students seeking detailed information in this area as well as for experts.
| Author | : Chaim Putterman |
| Publisher | : Academic Press |
| Total Pages | : 192 |
| Release | : 2018-05-14 |
| Genre | : Medical |
| ISBN | : 0128033703 |
Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease. - Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules - Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship - Features a collaborative editorial effort, involving clinical immunologists and structural biologists - Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology - Gives interested parties a bridge to learn about computer modeling and structure based design principles
| Author | : Eva Lotzova |
| Publisher | : CRC Press |
| Total Pages | : 524 |
| Release | : 1992-03-17 |
| Genre | : Medical |
| ISBN | : 9780849362675 |
This volume provides a state-of-the-art survey of developments in the field of NK cell-cancer cell interactions, activation, and oncolytic signaling. Specific topics discussed include NK cell receptors and adhesion molecules, signal transduction and activation, and mechanisms of cytotoxicity. The book will be an excellent learning tool and reference resource for scientists, clinicians, and students.
| Author | : Eva Lotzova |
| Publisher | : CRC Press |
| Total Pages | : 358 |
| Release | : 2019-07-23 |
| Genre | : Health & Fitness |
| ISBN | : 1000697215 |
First published in 1986: This book contributes to the advancing knowledge of reads in the field of NK cells, and will be helpful as a teaching device.
| Author | : Klas Kärre |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 250 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642468594 |
Our understanding of the function of natural killer (NK) cells has dramatically changed in recent years. The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal cell surface molecules. Such recognition events lead to intracellular signals which can be either stimulatory or inhibitory. This book provides an insight into how NK cells develop, how they learn to distinguish altered cells from normal cells, and into their biological role in controlling infections and tumors.
| Author | : Michael T. Lotze |
| Publisher | : Academic Press |
| Total Pages | : 709 |
| Release | : 2009-11-12 |
| Genre | : Medical |
| ISBN | : 0080919294 |
Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses. The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage to tissues, and regenerate damaged tissues. It discusses how these cells mature and develop, and it covers the different isolation, culture, and propagation methods of these cells. Furthermore, it focuses on the different killer cells that are present in various parts of the human body. The book concludes by explaining that natural killer cells are utilized for clinical therapy of malignancies, and that they have led to positive outcomes in the field of biology and medicine. - Provides a broad, detailed coverage of the biology and interactions of NK cells for students, fellows, scientists, and practitioners - Includes figures, histologic sections, and illustrations of the ontogeny of NK cells
