Frontiers in Stem Cell and Regenerative Medicine Research: Volume 10

Frontiers in Stem Cell and Regenerative Medicine Research: Volume 10
Author: Atta-ur-Rahman
Publisher: Bentham Science Publishers
Total Pages: 172
Release: 2022-03-03
Genre: Science
ISBN: 9811464685

Frontiers in Stem Cell and Regenerative Medicine Research Volume 10 [Edited for Volume 10] Stem cell and regenerative medicine research is an important area of clinical research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer’s disease and retinal disorders, among others, may well be addressed employing stem cell therapies and tissue regeneration techniques. Frontiers in Stem Cell and Regenerative Medicine Research brings updates on multidisciplinary topics relevant to stem cell research and their application in regenerative medicine. The series is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. Volume 10 includes 5 chapters on these topics: -Novel drugs and their stem cell-based targets for osteoporosis: challenges and proceedings -The role of cancer stem cells in disease progression and therapy resistance -Stem cells from human exfoliated deciduous teeth in tissue regeneration -The fate of toxicological studies: from animal models to stem cell-based methods -Effect of material properties on differentiation of mesenchymal stem cells

Hierarchically structured biomaterials for tissue regeneration

Hierarchically structured biomaterials for tissue regeneration
Author: Wenping Ma
Publisher: OAE Publishing Inc.
Total Pages: 34
Release: 2024-03-12
Genre: Technology & Engineering
ISBN:

Repairing tissue defects caused by diseases and traumas presents significant challenges in the clinic. Recent advancements in biomaterials have offered promising strategies for promoting tissue regeneration. In particular, the exploration of 3D macro and microstructures of biomaterials has proven crucial in this process. The integration of macro, micro, and nanostructures facilitates the performance of biomaterials in terms of their mechanical properties, degradation rate, and distinctive impacts on cellular activities. In this review, we summarize the recent progress in biomaterials with hierarchical structures for tissue regeneration. We explore the various methods and strategies employed in designing biomaterials with hierarchical structures of different dimensions. The improvement of physicochemical properties and bioactivities by hierarchically structured biomaterials, including the regulation of mechanical properties, degradability, and the specific functions of cell behaviors, has been highlighted. Furthermore, the current applications of hierarchically structured biomaterials for tissue regeneration are discussed. Finally, we conclude by summarizing the developments of hierarchically structured biomaterials for tissue regeneration and provide future perspectives.

Human Neural Stem Cells

Human Neural Stem Cells
Author: Leonora Buzanska
Publisher: Springer
Total Pages: 334
Release: 2018-09-12
Genre: Science
ISBN: 3319934856

This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.

Polymeric Biomaterials for Tissue Regeneration

Polymeric Biomaterials for Tissue Regeneration
Author: Changyou Gao
Publisher: Springer Nature
Total Pages: 578
Release: 2024-02-01
Genre: Medical
ISBN: 9819969484

This book reviews state of the art of polymeric biomaterials for regenerative medicine and highlights advances in both fundamental science and clinical practice. It summarizes the latest techniques in polymeric scaffold fabrication, delivery carriers, physiochemical property modulation, as well as their influence on the adhesion and performance of biomolecules, cells, and tissues. It also describes methods for creating biofunctional surfaces/interfaces and subsequently modulating the host response to implantable materials. Lastly, it discusses the applications of biomaterials and constructs in soft-tissue regenerative medicine. It is a valuable resource for materials scientists and engineers wishing to identify research priorities to fulfill clinical needs and provides physicians with insights into emerging novel biomaterials. This integrated approach also offers engineering students a sense of the relevance of materials science in the development of novel therapeutic strategies. In the second edition, most of the chapters are updated according to the latest progress of this research field. A new chapter on nerve regeneration is also included.

Bionanotechnology

Bionanotechnology
Author: David E. Reisner
Publisher: CRC Press
Total Pages: 368
Release: 2008-07-30
Genre: Medical
ISBN: 1420007734

As the impact and importance of nanotechnology continues to grow, nanomedicine and biotechnology have become areas of increased development. Drug delivery by nanoparticulates and nanocoatings for medicial devices are among the many new techniques on the horizon. Years from now we will laugh at the approaches to treating disease we currently conside

Biomaterials and Materials for Medicine

Biomaterials and Materials for Medicine
Author: Jingan Li
Publisher: CRC Press
Total Pages: 424
Release: 2021-09-29
Genre: Technology & Engineering
ISBN: 1000441164

Biomaterials and Materials for Medicine: Innovations in Research, Devices, and Applications provides an application-oriented summary of innovations in this rapidly evolving field, offering a view of various directions in biomaterials and medical materials and their advanced uses. Highlights vascular, orthopedic, skin tissue engineering, and nerve tissue engineering biomaterials, including the latest research on therapeutic devices and implants Introduces special stent materials for palliative treatment of esophageal cancer and related technologies of surface modification Discusses use of biomaterials and related designs in drug targeting and controlled release Describes wearable biomedical devices, biomimetic materials, and micronscale and nanoscale biomaterials Details the theoretical calculation and computer simulation of biomaterials as a complementary discipline with physical experimental science This book is aimed at an interdisciplinary group of researchers working on development and application of biomaterials for medical applications in the fields of materials scientists, biomedical engineering, and medicine.

Biomineralization and Biomaterials

Biomineralization and Biomaterials
Author: Conrado Aparicio
Publisher: Woodhead Publishing
Total Pages: 504
Release: 2015-09-28
Genre: Science
ISBN: 1782423567

Biomineralization is a natural process by which living organisms form minerals in association with organic biostructures to form hybrid biological materials such as bone, enamel, dentine and nacre among others. Scientists have researched the fundamentals of these processes and the unique structures and properties of the resulting mineralized tissues. Inspired by them, new biomaterials for tissue engineering and regenerative medicine have been developed in recent years. Biomineralization and biomaterials: fundamentals and applications looks at the characteristics of these essential processes and natural materials and describes strategies and technologies to biomimetically design and produce biomaterials with improved biological performance. - Provides a thorough overview of the biomineralization process - Presents the most recent information on the natural process by which crystals in tissues form into inorganic structures such as bone, teeth, and other natural mineralized tissues - Investigates methods for improving mineralization - Explores new techniques that will help improve the biomimetic process

Bone Tissue Engineering

Bone Tissue Engineering
Author: Jeffrey O. Hollinger
Publisher: CRC Press
Total Pages: 462
Release: 2004-10-14
Genre: Medical
ISBN: 1135501912

Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Biomedical Nanostructures

Biomedical Nanostructures
Author: Kenneth Gonsalves
Publisher: John Wiley & Sons
Total Pages: 543
Release: 2007-11-09
Genre: Science
ISBN: 0470185821

Learn to Use Nanoscale Materials to Design Novel Biomedical Devices and Applications Discover how to take full advantage of nanoscale materials in the design and fabrication of leading-edge biomedical devices. The authors introduce you to a variety of possible clinical applications such as drug delivery, diagnostics, and cancer therapy. In addition, the authors explore the interface between micron and nanoscale materials for the development of applications such as tissue engineering. Finally, they examine the mechanisms of cell interactions with material surfaces through the use of nanotechnology-based material processing and characterization methods. The text's three sections highlight its interdisciplinary approach: * Part One: Nanostructure Fabrication * Part Two: Bio-Nano Interfaces * Part Three: Clinical Applications of Nanostructures Among the key topics covered are nanotechnology in tissue regeneration; biomolecular engineering; receptor-ligand interactions; cell-biomaterial interactions; nanomaterials in diagnostics, drug delivery, and cancer therapy; and nano- and micron-level engineering and fabrication. Throughout the text, clear examples guide you through the chemistry and the processing involved in designing and developing nanoscale materials for biomedical devices. Each chapter begins with an introduction and ends with a conclusion highlighting the key points. In addition, references at the end of the chapter help you expand your research on any individual topic. In summary, this book helps biomedical researchers and engineers understand the physical phenomena that occur at the nanoscale in order to design novel cell-based constructs for a wide range of applications.