This book is a compilation of peer-reviewed papers presented at the International Conference on Machine Intelligence and Data Science Applications, organized by the School of Computer Science, University of Petroleum & Energy Studies, Dehradun, India, during 4–5 September 2020. The book addresses the algorithmic aspect of machine intelligence which includes the framework and optimization of various states of algorithms. Variety of papers related to wide applications in various fields like data-driven industrial IoT, bioinformatics, network and security, autonomous computing and various other aligned areas. The book concludes with interdisciplinary applications like legal, health care, smart society, cyber-physical system and smart agriculture. All papers have been carefully reviewed. The book is of interest to computer science engineers, lecturers/researchers in machine intelligence discipline and engineering graduates.