How “Sputnik V or Gam-Covid-Vac.” works.

How “Sputnik V or Gam-Covid-Vac.” works.
Author: Dr. Hakim. K. Saboowala
Publisher: Dr.Hakim Saboowala
Total Pages: 18
Release: 2021-05-05
Genre: Medical
ISBN:

How “Sputnik V or Gam-Covid-Vac.” works. The Sputnik V vaccine, developed by Gamaleya National Research Institute of Epidemiology and Microbiology in Moscow, uses two different viruses that cause the common cold (adenovirus) in humans. · The adenoviruses are weakened so they cannot replicate in humans and cannot cause disease. · They are also modified so that the vaccine delivers a code for making the coronavirus spike protein. This aims to ensure that when the real virus tries to infect the body, it can mount an immune response in the form of antibodies. Sputnik uses a different vector for each of the two Jabs in a course of vaccination. Thus, using a different adenovirus vector may help create a more powerful immune response (compared with using the same vector twice), as it minimizes the risk of the immune system developing resistance to the initial vector. This provides immunity with a longer duration than vaccines using the same delivery mechanism for both shots, according to the Russian Direct Investment Fund (RDIF). Sputnik V is approved for use in over 55 countries with a total population of over 1.5 billion people, according to RDIF. Thus, an attempt has been made in this Booklet to describe“How Sputnik V or Gam-Covid-Vac. works.”, along with relevant Illustrations for better understanding! Although care has been taken while compiling and checking information given in this Booklet to ensure that it is accurate, and none shall be responsible, in any way, liable for contemporaneousness of this information or for any errors, omissions or inaccuracies in this publication. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

Definition and Application of Terms for Vaccine Pharmacovigilance

Definition and Application of Terms for Vaccine Pharmacovigilance
Author: Council for International Organizations of Medical Sciences (CIOMS)
Publisher:
Total Pages: 0
Release: 2012
Genre: Drug Monitoring
ISBN: 9789290360834

This report from the Council for International Organizations of Medical Sciences (CIOMS) in collaboration with WHO covers the activities and outputs of the CIOMS/WHO Working Group on Vaccine Pharmacovigilance (2005-2010). This working group brought together experts from both industrialized and emerging countries representing regulatory agencies, vaccine industry, national and international public health bodies including WHO and CIOMS, academia and clinical care, contributing from their different perspectives. The report covers general terms and definitions for vaccine safety and discusses the application of such harmonized tools in vaccine safety surveillance and studies. As well, the report highlights case definitions for adverse events typically reported for vaccines. The report is addressed to those engaged in vaccine safety data collection and evaluation, and will also make a useful reading for others who want to familiarize themselves with vaccine safety terminology.

Neurological Care and the COVID-19 Pandemic - E-Book

Neurological Care and the COVID-19 Pandemic - E-Book
Author: Ahmad Riad Ramadan
Publisher: Elsevier Health Sciences
Total Pages: 201
Release: 2021-08-26
Genre: Medical
ISBN: 032382692X

Offering a comprehensive review of the neuropathology of SARS-CoV-2, Neurological Care and the COVID-19 Pandemic provides up-to-date coverage of the wide array of the pathogen's neurological symptoms and complications. Drs. Ahmad Riad Ramadan and Gamaledin Osman discuss the neuropathology of SARS-CoV-2, its neurological manifestations, and the impact the pandemic has had on the care of patients with pre-existing neurological conditions. The authors also offer an overview of emerging treatments and vaccines, as well as ways healthcare systems have reorganized in order to respond to the pandemic. - Offers a thorough discussion of the impact the virus has had on the care of patients with neurological ailments, accompanied by recommendations on how to care for these patients. - Covers the impact of COVID-19 on patients with cerebrovascular diseases, seizures, demyelinating diseases, neuromuscular disorders, movement disorders, headache disorders, cognitive disorders, and neuro-oncological disorders. - Includes a detailed case study of how one healthcare system hit hard by COVID-19 successfully transformed itself to respond to the challenges imposed by the pandemic. - Consolidates today's available information on this timely topic into a single, convenient resource.

Mucosal Vaccines

Mucosal Vaccines
Author: Hiroshi Kiyono
Publisher: Elsevier
Total Pages: 501
Release: 1996-10-23
Genre: Medical
ISBN: 0080537057

This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. - Provides the latest views on mucosal vaccines - Applies basic principles to the development of new vaccines - Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases - Unique and user-friendly organization

Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy
Author: David T. Curiel
Publisher: Academic Press
Total Pages: 870
Release: 2016-03-10
Genre: Science
ISBN: 0128005106

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. - Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors - Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement - Demonstrates noninvasive imaging of adenovirus-mediated gene transfer - Discusses utility of adenoviral vectors in animal disease models - Considers Federal Drug Administration regulations for human clinical trials

The Adenoviruses

The Adenoviruses
Author: Harold S. Ginsberg
Publisher: Springer Science & Business Media
Total Pages: 620
Release: 2013-03-08
Genre: Medical
ISBN: 1468479350

The discovery of adenoviruses naturally induced a new interest in viruses of the human upper respiratory tract since previously unknown viruses infecting this portion of the human body had not been identified in 20 years, and their unique characteristics stimulated investigations into the biochemical events essential for replication of animal viruses. Indeed, the field of molecular virology has evolved during the period since their dis covery, and adenoviruses have played a major role in this development. The exciting discoveries made with adenoviruses have had such a pro found effect on knowledge in basic virology, molecular biology, viral ge netics, human and animal infections, and cell transformation that this seemed a propitious time to have some of the major contributors review this field. This volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. Harold S. Ginsberg vii Contents Chapter 1 An Overview 1 Harold S. Ginsberg Chapter 2 The Architecture of Adenoviruses M. V. Nermut I. Introduction ................................... . 5 II. Chemical and Physical Properties ................... . 6 III. Virus Capsid: Composition and Organization .......... . 7 A. Hexon ..................................... . 10 B. Penton .................................... . 12 C. Other Virus Polypeptides Associated with the Capsid 13 D. Organization of the Capsid ..................... . 14 IV. Virus Core .................................... . 15 A. Evidence for the Core Shell ..................... . 17 B. Organization of the DNA-Protein Complex (Nucleoc- sid) ....................................... . 18 C. Tentative Model of the Adenovirus Nucleocapsid ... . 22 V. Model of the Adenovirion ......................... . 29 32 References .......................................... .

Dissecting the COVID-19 Pandemic

Dissecting the COVID-19 Pandemic
Author: Ramkrishna Nirola
Publisher: Aawaran Publications
Total Pages: 200
Release: 2021-05-19
Genre: Computers
ISBN: 9937945917

So far, several fascinating and fancy stuff have been imagined by humans. Not all imaginations are bound to happen and could be experienced. However, the current pandemic (COVID-19) seems, and now is set to surpass beyond what a human brain could have imagined. A deep socio-economic scar is in the process of being created and nobody yet knows how deep this wound is going to penetrate. At this juncture, we have congregated to produce a book entitled “Dissecting the COVID-19 Pandemic”, through the facades of global socio-economic impact. It is our pleasure to try to compile what we have seen and hence present the factual accounts to the people post February 2020, and for the days to come. It is a history unfolding, an array of events in front of the human kind. Our effort in witnessing, reviewing, compiling, and binding is definitely going to be a memorabilia of the time it has witnessed. It is said that “seeing is believing”, and here, the authors have factually seen and have by now certainly believed that COVID-19 is not just a simple flu. The pandemic crises of COVID-19 has shaken the world, and its impact is multidimensional and has adversely influenced many aspects of human life. Globally, over 22 million people were infected, and over 4.5 million have died in 215 countries, when this book was in the press. The eight chapters of this book cover various facades of the coronavirus crises, plus their impact globally and particularly in Nepal. The information is relevant to many developing countries. The chapters are written by science scholars, engineers, media analysts, development experts, and scientists in allied disciplines in Australia and Nepal. The contributing authors have both knowledge and experiences of Nepal and overseas in the subject matter and have provided evidence-based information. Our publication efforts and contribution to Nepal and Nepali diaspora deserve special mention. We hope this book will generate enough interest and stimulate significant discourses among scholars, policymakers, and the community at large to advocate for an inclusive health, disaster risk reduction (DRR), diplomacy and migration policy to overcome future pandemic challenges. Finally, we acknowledge the support of NRNA-Australia, Nepal Science Foundation Trust-SK & TT Department, Nepal Academy of Science and Technology (NAST), Embassy of Nepal-Canberra, Federation of Nepalese Community Associations of Australia (FeNCAA), Australasian Nepalese Medical and Dental Association- Australia (ANMDA), and Aawaran publication for their support to bring out this book.

Latin American Economic Outlook 2021 Working Together for a Better Recovery

Latin American Economic Outlook 2021 Working Together for a Better Recovery
Author: OECD
Publisher: OECD Publishing
Total Pages: 274
Release: 2021-12-02
Genre:
ISBN: 9264682317

The Latin American Economic Outlook 2021: Working Together for a Better Recovery aims to analyse and provide policy recommendations for a strong, inclusive and environmentally sustainable recovery in the region. The report explores policy actions to improve social protection mechanisms and increase social inclusion, foster regional integration and strengthen industrial strategies, and rethink the social contract to restore trust and empower citizens at all stages of the policy‐making process.

Coronavirus (COVID-19) Outbreaks, Environment and Human Behaviour

Coronavirus (COVID-19) Outbreaks, Environment and Human Behaviour
Author: Rais Akhtar
Publisher: Springer Nature
Total Pages: 483
Release: 2021-04-22
Genre: Medical
ISBN: 3030681203

This book covers over 24 country studies on various dimensions associated with the geographical spread of COVID-19. The chapters in the book, from geographically diversified countries, assert the need to undertake intensive regional research in order to understand the global pattern of Coronavirus focusing on infection migration, and indigenous origin that has caused tremendous global economic, social and health disaster. The book contends that understanding of peoples’ behaviour is crucial towards safety measures against infection, as COVID-19 impacted to a greater extent social wellbeing of population because of lockdowns in all corners of the world. Some of the countries featured are USA, France, Italy, Hong Kong, South Korea, Canada, Australia, Pacific Islands, Russia, Taiwan, Thailand, Malaysia, Indonesia, India, South Africa, Nigeria, Mexico, Peru and Brazil.

European-Russian Space Cooperation

European-Russian Space Cooperation
Author: Brian Harvey
Publisher: Springer Nature
Total Pages: 406
Release: 2021-04-10
Genre: Technology & Engineering
ISBN: 3030676862

The story of European-Russian collaboration in space is little known and its importance all too often understated. Because France was the principal interlocutor between these nations, such cooperation did not receive the attention it deserved in English-language literature. This book rectifies that history, showing how Russia and Europe forged a successful partnership that has continued to the present day. Space writer Brian Harvey provides an in-depth picture of how this European-Russian relationship evolved and what factors—scientific, political and industrial—propelled it over the decades. The history begins in the cold war period with the first collaborative ventures between the Soviet Union and European countries, primarily France, followed later by Germany and other European countries. Next, the chapters turn to the missions when European astronauts flew to Russian space stations, the Soyuz rocket made a new home in European territory in the South American jungle and science missions were flown to study deep space. Their climax is the joint mission to explore Mars, called ExoMars, which has already sent a mission to Mars. Through this close examination of these European-Russian efforts, readers will appreciate an altogether new perspective on the history of space exploration, no longer defined by competition, but rather by collaboration and cooperation.