Host Cell Factors Involved In Retrovirus Replication And Disease Pathogenesis
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Author | : Shannon Beth Seidel |
Publisher | : |
Total Pages | : 143 |
Release | : 2012 |
Genre | : |
ISBN | : 9781267470218 |
Retroviruses are relevant human pathogens affecting the lives of tens of millions of people globally each year and resulting in nearly 2 million deaths annually. Understanding the process of retrovirus infection has wide benefits including the identification of therapeutic targets to treat HIV/AIDS and better understanding of cellular pathways disrupted in diseases, such as cancer and AIDS. Here, I first present my role in a collaborative project that led to the identification of over 200 cellular factors with potentially important roles in the early stages of retrovirus infection. We identified these factors through a genome-wide siRNA screen and through characterization of interactions between host and virus proteins. Additionally, I present my work on ZASC1, a host cell transcription factor that binds to the promoter regions of both HIV-1 and MLV and regulates virus gene expression in cultured established cell lines. I generated a ZASC1 knockout mouse model, showing that this gene is non-essential to development and reproduction. This mouse model was used to characterize the role of ZASC1 in retrovirus replication and disease pathogenesis. I showed that ZASC1 influences myeloid cell differentiation in this compartment and that this transcription factor is required for efficient early Mo-MuLV infection in the bone marrow compartment. Through studies of Mo-MuLV pathogenesis in the ZASC1 knockout mouse model, I show that despite this early defect, tumorigenesis is not regulated by ZASC1.
Author | : Bryan Cullen |
Publisher | : Oxford University Press |
Total Pages | : 220 |
Release | : 1993 |
Genre | : Gene Expression Regulation. |
ISBN | : 9780199633821 |
The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.
Author | : John A.T. Young |
Publisher | : Springer Science & Business Media |
Total Pages | : 250 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 364219012X |
The articles in this volume provide a comprehensive overview of our current understanding of the roles played by cellular factors in the early steps of retroviral replication. A better understanding of these functions will provide critical new insights into retrovirus-host cell interactions and is likely to prove useful for the future development of effective antiretroviral therapies.
Author | : Reinhard Kurth |
Publisher | : Caister Academic Press Limited |
Total Pages | : 0 |
Release | : 2010 |
Genre | : Science |
ISBN | : 9781904455554 |
Leading scientists in the field review the genomics, molecular biology and pathogenesis of these important viruses, comprehensively covering all the recent advances.
Author | : David S. Hui |
Publisher | : European Respiratory Society |
Total Pages | : 148 |
Release | : 2016-06-01 |
Genre | : Medical |
ISBN | : 1849840709 |
Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.
Author | : A. M. L. Lever |
Publisher | : World Scientific |
Total Pages | : 502 |
Release | : 2010 |
Genre | : Science |
ISBN | : 9814295302 |
There are three major types of human retroviruses, namely HIV, HTLV, and endogenous human retroviruses. This book presents the latest findings on the replication of these human retroviruses. This book is unique in that there has been no comparable book that integrates the findings from the three known classes of human retroviruses. Other books have focused on one of the three classes of human retroviruses individually. An accomplished international team of contributing authors have combined their expertise to provide cutting-edge findings in this important field. The book will be a valuable reference for students, researchers and medical professionals.
Author | : Henry Puerta-Guardo |
Publisher | : BoD – Books on Demand |
Total Pages | : 170 |
Release | : 2024-03-13 |
Genre | : Medical |
ISBN | : 085466467X |
Viruses pose a huge burden on public health systems and the economy worldwide. In the case of humans, viruses make up about two-thirds of all new human pathogens. Both DNA and RNA viruses can cause acute, persistent, or latent infections, as they can integrate their genome into the host DNA, such as the endogenous retroviruses, which can be associated with a wide variety of cancers in animals and humans. In recent years, viruses have emerged not only as a health threat but also as a potential alternative for producing new diagnostic tools as well as prophylactic/therapeutic approaches to defeat viral diseases. This book provides a broadly comprehensive series of reviews describing the replication strategies used for both DNA and RNA viruses, their interaction with the host immune system, and their potential role in tumorigenicity and cancer immunotherapy as applied to various viruses of critical relevance for human or animal diseases.
Author | : Leslie Parent |
Publisher | : Academic Press |
Total Pages | : 622 |
Release | : 2018-08-09 |
Genre | : Science |
ISBN | : 0128111933 |
Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences. - Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication - Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics - Features important commonalities and differences among retroviral systems
Author | : Jennifer Louten |
Publisher | : Academic Press |
Total Pages | : 412 |
Release | : 2022-05-28 |
Genre | : Science |
ISBN | : 0323914926 |
Essential Human Virology, Second Edition focuses on the structure and classification of viruses, virus transmission and virus replication strategies based upon type of viral nucleic acid. Several chapters focus on notable and recognizable viruses and the diseases caused by them, including influenza, HIV, hepatitis viruses, poliovirus, herpesviruses and emerging and dangerous viruses. Additionally, how viruses cause disease (pathogenesis) is highlighted, along with discussions on immune response to viruses, vaccines, anti-viral drugs, gene therapy, the beneficial uses of viruses, research laboratory assays and viral diagnosis assays. Fully revised and updated with new chapters on coronaviruses, nonliving infectious agents, and notable non-human viruses, the book provides students with a solid foundation in virology. - Focuses on human diseases and the cellular pathology that viruses cause - Highlights current and cutting-edge technology and associated issues - Presents real case studies and current news highlights in each chapter - Features dynamic illustrations, chapter assessment questions, key terms, and a summary of concepts, as well as an instructor website with lecture slides, a test bank and recommended activities - Updated and revised, with new chapters on coronaviruses, nonliving infectious agents, and notable non-human viruses
Author | : Alan Cann |
Publisher | : Elsevier |
Total Pages | : 340 |
Release | : 2005-07-26 |
Genre | : Medical |
ISBN | : 9780120887897 |
"Principles of Molecular Virology, Fourth Edition" provides an essential introduction to modern virology in a clear and concise manner. It is a highly enjoyable and readable text with numerous illustrations that enhance the reader's understanding of important principles. It contains new material on virus structure, virus evolution, zoonoses, bushmeat, SARS and bioterrorism. The standard version includes a CD-ROM with Flash animations, virtual interactive tutorials and experiments, self-assessment questions, useful online resources, along with the glossary, classification of subcellular infectious agents and history of virology.