Hormone Resistance And Other Endocrine Paradoxes
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Author | : Margo P. Cohen |
Publisher | : Springer Science & Business Media |
Total Pages | : 260 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461247586 |
Endocrinology and Metabolism: Progress in Research and Clinical Prac tice is a new series that has been designed to present timely, critical reviews of constantly evolving fields; to provide practical and up-to-date guidance in the solution of pertinent clinical problems; to offer an alterna tive to the laborious search of the literature (and the often frustrating reading of highly technical articles); and to translate the language of the laboratory into that of the practice of medicine. We think that this volume and those to come will prove useful to physi cians (and to physicians in training), as well as to investigators in a wide variety of specialties; in short, to anyone who seeks answers to questions in endocrinology and metabolism. The first chapter of this volume could well serve as a general introduc tion to the entire series. It points out how our growing understanding of the molecular basis of biologic communication has led to the discovery of a growing number of clinical syndromes, as well as to the realization that phenotypically similar diseases may have radically different pathogenetic mechanisms and thus may require radically different therapeutic strata gems.
Author | : James K. Rone |
Publisher | : ReadHowYouWant.com |
Total Pages | : 231 |
Release | : 2010-01-07 |
Genre | : Medical |
ISBN | : 1458712788 |
Don't be satisfied with business-as-usual health care. If you suffer low thyroid - or think you might - and want to learn more, especially if you're unsatisfied with the answers you're getting from your doctor, this book is for you. An estimated 5.8% of women and 3.4% of men in the United States are hypothyroid. Low thyroid is common, yet, paradoxically, may be rampantly overlooked. Why? As you'll discover in The Thyroid Paradox, there is a pervasive oversimplification of thyroid science and mainstream treatment of thyroid patients today. Current thyroid testing has weaknesses and should be interpreted, not in a vacuum, but as part of a diagnostic process based on all the evidence. Too often, doctors simply stick to test results and miss patients suffering with subtle hypothyroidism. The Thyroid Paradox is for the person who's been told ''It's not your thyroid, '' without then being told convincingly what it is. Maybe you've been told nothing is wrong but know there must be some reason for your chronic fatigue, body aches, weight gain, dry skin, constipation, ''brain fog, '' depression, or menstrual irregularity. This book provides the answers for you. You'll learn about: The loopholes in current thyroid testing; Hidden forms of hypothyroidism and how to detect them; The best strategies for thyroid replacement. The path out of the thyroid paradox is engaged teamwork involving both doctor and patient. This book should provide you with the knowledge you need to communicate and work with your doctor to get the treatment you deserve.
Author | : Georg Hennemann |
Publisher | : Marcel Dekker |
Total Pages | : 656 |
Release | : 1986 |
Genre | : Medical |
ISBN | : |
Author | : George H. Gass |
Publisher | : CRC Press |
Total Pages | : 312 |
Release | : 1996-06-17 |
Genre | : Medical |
ISBN | : 9780849394300 |
Stay on top of the rapid changes sweeping endocrinology today with the latest information on important selected topics in The Handbook of Endocrinology. This extensive two-volume text provides an impressive breadth and depth of coverage difficult to find in other sources. After a broad survey of the functions of major endocrine glands, the book launches into detailed reviews of both established and hot, new research areas. Selected topics include:
Author | : Margaret A. Shupnik |
Publisher | : Springer Science & Business Media |
Total Pages | : 439 |
Release | : 2000-04-01 |
Genre | : Medical |
ISBN | : 159259221X |
During the past five to ten years, a variety of tools has been developed in the disciplines of both gene engineering, and molecular and structural biology. Some of these advances have permitted scientists not only to identify and characterize genes, but also to target these genes by disruption, thus eliminating their function in living animals, and to det- mine the biological responses to altered gene products. This has particular significance in endocrine systems, in which feedback mechanisms between the hypothalamus, pi- itary, and end organs are critical in normal physiology. Interpretation of the physiological significance, or the site of action of specific molecules in this context, has been difficult prior to transgenic technology. Major advances have occurred specifically in the areas of growth and development, and of reproduction. Coupled with analysis of naturally occurring mutations in humans, the use of transgenic animals and in vitro systems has recently allowed endocrinologists to understand the importance of specific thyroid hormone receptor isoforms in vivo, the molecular basis for generalized resistance to thyroid hormones via mutations in the nuclear receptor, and mechanisms for suppressing gene transcription. Previously designated “orphan rec- tors,” such as steroidogenic factor-1, were demonstrated to have critical roles in dev- opment and reproduction. Other nuclear receptors—including those for thyroid hormone, estrogens, androgens, and progesterone—were shown to bind to coactivator and co- pressor proteins that modified their transcriptional activity, and contributed to the ce- specific effects of the hormones.
Author | : National Library of Medicine (U.S.) |
Publisher | : |
Total Pages | : 1036 |
Release | : 1988 |
Genre | : Medicine |
ISBN | : |
Author | : James H. Clark |
Publisher | : Academic Press |
Total Pages | : 372 |
Release | : 2013-10-22 |
Genre | : Medical |
ISBN | : 1483219666 |
Recent Progress in Hormone Research, Volume 46 provides a superior summary of the developments in the field of hormone research. The book discusses the molecular basis of androgen insensitivity; the tissue-specific expression of the growth hormone gene and its control by growth hormone factor-1; and the molecular characterization of mammalian tachykinin receptors and a possible epithelial potassium channel. The text also describes the properties of the guanylate cyclase receptor family; insulin-like growth factor-binding proteins; and growth hormone receptor and binding protein. Mutations in the insulin receptor gene in genetic forms of insulin resistance; the characteristics of the cAMP response unit; and the role and secretion of inhibin in the rat are also considered. The book further tackles the structure of the lutropin/choriogonadotropin receptor and the gene for multiple endocrine neoplasia type 2a. Endocrinologists, physiologists, and biochemists will find the text invaluable.
Author | : Piero P. Foa |
Publisher | : Springer Science & Business Media |
Total Pages | : 605 |
Release | : 2013-03-07 |
Genre | : Science |
ISBN | : 1461225965 |
Omnis cellula e cellula, "every cell from a cell," was dogma to the 19th century cellular physiologist and the cornerstone of Virchow's Cellular pathologie. "Spread out a cell into a layer and you will find that, in ceasing to be a cell, it has ceased to act as such," wrote the British 1 physiologist G . R. Lewes more than a century age. "The cell remains vital as long as its wall remains intact . . . " keeping its content "pure and clear" and thus preserving the "vital principle" within, echoed Claude 2 Bernard a few years later. The notion of the cell membrane as a pro tecting envelope held sway until it became clear that it could not account for the "coalescence" of poorly differentiated embryonic "vesicles" and for their transformation into "cell-like structures" capable of auto regulation and yet subject to what the grandfather of one of us defined as the "federal obligations imposed by the whole organism. ,,3 A new concept was needed, and soon the membrane was described as a structure capable of uniting as well as separating adjacent cells. Morphologic evidence for this dual function was obtained several years later when the electron microscope revealed the existence of tight and gap junc tions which, acting as intercellular bonds and channels, allowed the cells to communicate with one another and thus coordinate their biologic activities.
Author | : Piero P. Foa |
Publisher | : Springer Science & Business Media |
Total Pages | : 326 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461392721 |
Experts in the field of endocrinology as well as ophthalmologists, oncologists, orthopedists and oral surgeons discuss the nature and mechanism of action of growth-stimulating substances whose biological and clinical activities in humans have been demonstrated or are being investigated. The monograph represents a good sampler of current basic and applied knowledge in the field.
Author | : Chuck Kelly |
Publisher | : John Wiley & Sons |
Total Pages | : 552 |
Release | : 1996-02-13 |
Genre | : Medical |
ISBN | : 9780471133209 |
Pharmacology, Biology, and Clinical Applications of AndrogensCurrent Status and Future Prospects Edited by Shalender Bhasin, Henry L. Gabelnick, Jeffrey M. Spieler,Ronald S. Swerdloff, Christina Wang, and Chuck Kelly As agents that affect the male primary and accessory sex organs,androgens--particularly the hormones testosterone andandrosterone--play a critical role in the development,functionality, and overall health of the male reproductive system.However, since androgens also have far-ranging effects onmetabolism, neurological activity, and behavior, scientistsexploring the contraceptive or therapeutic potential of androgensneed reliable, up-to-date information on the complex biologicalactivities of these agents. Pharmacology, Biology, and Clinical Applications of Androgens:Current Status and Future Prospects presents contributions fromleading investigators around the world, offering a focused,state-of-the-art summary of the central issues and controversies inandrogen research. The book is arranged into sections coveringandrogen physiology, androgens and the prostate, and theneurobehavioral and metabolic effects of androgens--as well astheir role in disease therapy and male contraception, and thevarious delivery systems for each application. Every chapter in thetext provides an expert opinion on a cutting-edge topic in thefield while highlighting the key points of dissent and disagreementwithin the scientific community. This approach is intended tofoster a deeper understanding of the status of androgen researchand lay the groundwork for future investigations in eacharea. This book explores such current topics as: * Androgen regulation of Sertoli cell function * Testosterone and spermatogenesis * Androgen effects on benign prostatic hyperplasia (BPH) andprostate cancer * Androgen effects on cognitive processes, sexual function, andaggressive behavior * Contraceptive efficacy of hormonal suppression of spermatogenesis * The latest transdermal and implantation delivery systems forandrogens Offering multifaceted coverage of the field, Pharmacology, Biology,and Clinical Applications of Androgens is an indispensable aid toall basic scientists and clinical investigators interested in thebiological actions of either natural or synthetic androgens.