Highly Selective Separations In Biotechnology
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| Author | : G. Street |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 242 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 940111322X |
Success in meeting the challenge to produce the commercial products anticipated by the exploitation of biological processes depends upon provid ing effective separation protocols. Effectiveness can be measured in terms of selectivity, purity, resolution and validatory success. The major processing problems are associated with either the selective recovery of molecules which are present in low concentrations from complex mixtures or the selective removal of contaminants from the desired molecule. Central to the evolution of processes satisfying this demand are the regulatory requirements being imposed by governments on the purity of a product, especially in the health care market. Synthetic organic chemists are increasingly finding it advantageous to conduct one or more steps using either enzymic biotransformations where molecules with a single and consistent stereochemistry or chirality are required. The underlying princi ples behind the methods, techniques and processes currently being used and developed commercially rely upon the biospecific nature and properties of the desired molecule. When these factors are married to the more traditional techniques of precipitation, chromatography, liquid-liquid extraction and membrane processes, powerful tools emerge, allowing highly selective separations to be designed. The logical extension of these combinations is to apply genetic engineering techniques to influence the separations at a more fundamental and structural level by modifying the target protein at source, during its synthesis, to facilitate its separation in a given, selective manner, leading to the distinct possibility of producing 'designer' separation programmes.
| Author | : D. Leo Pyle |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 659 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 9400907834 |
The challenge of bioseparations is to isolate and purify identified products from the dilute product broth produced from cell culture. Innovation in bioseparations technology is increasingly driven by the requirements imposed by the growing importance of production on a process scale of injectable-grade products, and economic pressures to improve the efficiency of downstream processing. As in other areas of technical change, science does not necessarily precede new technology: progress results from a complex and messy mixture of advances in understanding, ingenious ideas, novel techniques and chance discoveries. What is certain is that close interaction between academics and practitioners, biological scientists and process engineers is needed to solve the problems of bioseparations. The Second International Conference on Separations for Biotechnology at Reading, UK, in September 1990 set out to provide a critical multidisciplinary forum for the discussion of bioseparations. This volume contains the papers presented at the meeting. The meeting was organised around six themes with oral and poster presentations on the science and practice of bioseparations technology, and the same structure has been kept for this book. We have also included the texts of the keynote review paper by Professor Alan Michaels and the introductory review papers specially commissioned for the conference. Within each part of this book the review paper is followed by the contributed papers grouped alphabetically by their first author. All the original papers published here were accepted for publication after scientific refereeing.
| Author | : |
| Publisher | : |
| Total Pages | : 680 |
| Release | : 1990 |
| Genre | : Biomolecules |
| ISBN | : |
| Author | : Fedor Macášek |
| Publisher | : Xlibris Corporation |
| Total Pages | : 390 |
| Release | : 2016-06-06 |
| Genre | : Science |
| ISBN | : 1514417308 |
Separation of chemical species is a gate to final success of synthesis and preparation of compounds in pure and defined state. Variability of natural and artificial mixtures to be treated is enormous. Task of chemistry is to separate components of homogeneous mixtures (the gaseous and liquid solutions). The book concentrates on understanding the basic philosophies of both equilibrium and nonequilibrium chemical thermodynamics and engineering performance that lay in principle of separation technique such as distillation, crystallization, centrifugation, sorption, membrane separations, chromatography, and liquid-liquid extraction. Specific phenomena connected with photochemical separation, isotope composition, and radioactivity are discussed as well. The book is written for advanced students of chemistry having the knowledge of physical chemistry. Calculation examples are based on the international system of units. Unique list of over 1,300 full references covers scientific literature of the eighteenth to the twenty-first centuries.
| Author | : Rui L. Reis |
| Publisher | : Elsevier |
| Total Pages | : 829 |
| Release | : 2008-08-15 |
| Genre | : Science |
| ISBN | : 1845694813 |
Polymers from natural sources are particularly useful as biomaterials and in regenerative medicine, given their similarity to the extracellular matrix and other polymers in the human body. This important book reviews the wealth of research on both tried and promising new natural-based biomedical polymers, together with their applications as implantable biomaterials, controlled-release carriers or scaffolds for tissue engineering.The first part of the book reviews the sources, processing and properties of natural-based polymers for biomedical applications. Part two describes how the surfaces of polymer-based biomaterials can be modified to improve their functionality. The third part of the book discusses the use of natural-based polymers for biodegradable scaffolds and hydrogels in tissue engineering. Building on this foundation, Part four looks at the particular use of natural-gelling polymers for encapsulation, tissue engineering and regenerative medicine. The penultimate group of chapters reviews the use of natural-based polymers as delivery systems for drugs, hormones, enzymes and growth factors. The final part of the book summarises research on the key issue of biocompatibility.Natural-based polymers for biomedical applications is a standard reference for biomedical engineers, those studying and researching in this important area, and the medical community. - Examines the sources, processing and properties of natural based polymers for biomedical applications - Explains how the surfaces of polymer based biomaterials can be modified to improve their functionality - Discusses the use of natural based polymers for hydrogels in tissue engineering, and in particular natural gelling polymers for encapsulation and regenerative medicine
| Author | : Maria Rosa Aguilar |
| Publisher | : Woodhead Publishing |
| Total Pages | : 704 |
| Release | : 2019-02-15 |
| Genre | : Technology & Engineering |
| ISBN | : 0081024177 |
Smart Polymers and Their Applications, Second Edition presents an up-to-date resource of information on the synthesis and properties of different types of smart polymers, including temperature, pH, electro, magnetic and photo-responsive polymers, amongst others. It is an ideal introduction to this field, as well as a review of the latest research in this area. Shape memory polymers, smart polymer hydrogels, and self-healing polymer systems are also explored. In addition, a very strong focus on applications of smart polymers is included for tissue engineering, smart polymer nanocarriers for drug delivery, and the use of smart polymers in medical devices. Additionally, the book covers the use of smart polymers for textile applications, packaging, energy storage, optical data storage, environmental protection, and more. This book is an ideal, technical resource for chemists, chemical engineers, materials scientists, mechanical engineers and other professionals in a range of industries. - Includes a significant number of new chapters on smart polymer materials development, as well as new applications development in energy storage, sensors and devices, and environmental protection - Provides a multidisciplinary approach to the development of responsive polymers, approaching the subject by the different types of polymer (e.g. temperature-responsive) and its range of applications
| Author | : K. Scott |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 326 |
| Release | : 1996 |
| Genre | : Gardening |
| ISBN | : 9780751403381 |
Although membrane separations can now routinely replace traditional separations, there is a need for the new developments in the applications and theories of membrane separation to be transmitted to industry to continue the drive forward in membrane development. This book presents new developments in the context of industrial technology and relates the principles of design to plant set-up and equipment selection.
| Author | : Rajni Hatti-Kaul |
| Publisher | : CRC Press |
| Total Pages | : 688 |
| Release | : 2003-02-05 |
| Genre | : Medical |
| ISBN | : 9780203911686 |
This publication details the isolation of proteins from biological materials, techniques for solid-liquid separation, concentration, crystallization, chromatography, scale-up, process monitoring, product formulation, and regulatory and commercial considerations in protein production. The authors discuss the release of protein from a biological host, selectivity in affinity chromatography, precipitation of proteins (both non-specific and specific), extraction for rapid protein isolation, adsorption as an initial step for the capture of proteins, scale-up and commercial production of recombinant proteins, and process monitoring in downstream processing.
| Author | : Anil K. Pabby |
| Publisher | : CRC Press |
| Total Pages | : 601 |
| Release | : 2023-12-22 |
| Genre | : Science |
| ISBN | : 1003811574 |
The third edition of the Handbook of Membrane Separations: Chemical, Pharmaceutical, Food, and Biotechnological Applications provides a comprehensive discussion of membrane applications. Fully updated to include the latest advancements in membrane science and technology, it is a one-of-its-kind overview of the existing literature. This fully illustrated handbook is written by experts and professionals in membrane applications from around the world. Key Features: Includes entirely new chapters on organic solvent-resistant nanofiltration, membrane condensers, membrane-reactors in hydrogen production, membrane materials for haemodialysis, and integrated membrane distillation Covers the full spectrum of membrane technology and its advancements Explores membrane applications in a range of fields, from biotechnological and food processing to industrial waste management and environmental engineering This book will appeal to both newcomers to membrane science as well as engineers and scientists looking to expand their knowledge on upcoming advancements in the field.
| Author | : Michael Zachariou |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 341 |
| Release | : 2008 |
| Genre | : Medical |
| ISBN | : 1588296598 |
Thirty-eight years after its introduction, affinity chromatography remains a key tool in the armory of separation techniques available to separation and interaction scientists. Expanded and updated from the first edition, Affinity Chromatography: Methods and Protocols, Second Edition, provides the beginner with the practical knowledge needed to develop affinity separations suitable for a variety of applications relevant to the post-genomic era. This second edition expands on the first edition by introducing more state-of-the-art protocols used in affinity chromatography. This new edition also describes protocols that demonstrate the concept of affinity chromatography being applied to meet the modern high throughput screening demands of researchers and development scientists whilst expanding on some more traditional affinity chromatography approaches that have become of greater interest to separation scientists. Chapters in this cutting-edge text expand on affinity chromatography techniques that currently enjoy frequent citation in the literature from those purifying biomolecules. Other chapters include protocols describing the use of a variety of fusion tags as well as how to cleave them, so as to allow the scientists to study the native phenotype of the protein. Renowned researchers also include protocols detailing diverse applications of affinity chromatography such as its use in catalytic reactions, DNA purification, whole cell separations and for the isolation of phosphorylated proteins. Affinity Chromatography: Methods and Protocols, Second Edition, is an essential reference for those interested in separation sciences, particularly in the pharmaceutical and biological research sectors, that have an interest in isolating macromolecules rapidly, quantitatively, and with high purity.
