Static analysis is a research area aimed at developing principles and tools for veri?cation, certi?cation, semantics-based manipulation, and high-performance implementation of programming languages and systems. The series of Static Analysis symposia has served as the primary venue for presentation and disc- sion of theoretical, practical, and application advances in the area. This volume contains the papers accepted for presentation at the 15th Inter- tional Static Analysis Symposium (SAS 2008), which was held July 16–18, 2008, in Valencia, Spain. The previous SAS conferences were held in Kongens Lyngby, D- mark (2007), Seoul, South Korea (2006), London, UK (2005), Verona, Italy (2004), San Diego, USA (2003), Madrid, Spain (2002), Paris, France (2001), Santa B- bara, USA (2000), Venice, Italy (1999), Pisa, Italy (1998), Paris, France (1997), Aachen, Germany (1996), Glasgow, UK (1995), and Namur, Belgium (1994). In response to the call for papers, 63 contributions were submitted from 26 d- ferent countries. The Program Committee selected 22 papers, basing this choice on their scienti?c quality, originality, and relevance to the symposium. Each - per was reviewed by at least three Program Committee members or external r- erees. In addition to the contributed papers, this volume includes contributions by two outstanding invited speakers: Roberto Giacobazzi (Universit` a degli Studi di Verona) and Ben Liblit (University of Wisconsin-Madison). The resulting volume o?ers the reader a complete landscape of the research in this area.