Hibernation and the Hypothalamus

Hibernation and the Hypothalamus
Author: Nicholas Mrosovsky
Publisher: Springer Science & Business Media
Total Pages: 296
Release: 2012-12-06
Genre: Science
ISBN: 1468471767

Mammalian hibernation is commonly thought of as something completely out of the ordinary, a "unique and unorthodox state." The present book takes the opposite view. It argues that the physiological achievements of hibernators do not deEend on special mechanisms but on special use of ordinary mechanisms. It is precisely this that makes the hibernators important. If the hibernators de pend on some unique physiological principle their study is that of a biological curio. But if they are using basic mammalian systems in a quantitatively extreme way, then they are a naturally occurring preparation of enormous potential. Hibernation involves every aspect of the animal's biology from fat metabo lism to behavior, from thermoregulation to dental caries; every system in the body is affected in some way or other by hibernation. A comprehensive account of hibernation would be almost coextensive with an account of the whole of mammalian biology. The present book does not attempt to describe everything that has been discovered about hibernation. Excellent coverage for that already exists in the proceedings of three recent symposia and in the other major source materials listed on page 233. There is in fact an enormous amount of information already available. But there is a difference between information and understanding. Despite the increasing volume of research and growing interest in mammalian hibernation, there is little appreciation of the essential characteristics of the phenomena. The pieces of the puzzle lie scattered.

Brain Hypothermia

Brain Hypothermia
Author: N. Hayashi
Publisher: Springer Science & Business Media
Total Pages: 253
Release: 2012-12-06
Genre: Medical
ISBN: 4431668829

Rapid progress in technology and its application to diagnosis and monitoring of brain tissue temperature and metabolism have resulted in advances in the therapy for critically brain-injured patients and breakthroughs in understanding the pathophysiology of brain damage. The latest concept of brain hypothermia therapy clarifies targets such as brain thermal pooling, masking brain hypoxia associated with catecholamine surge, the metabolic shift from glucose to lipids, and selective radical damage of dopamine in the central nervous system. This volume explains the mechanism of brain injury and how brain hypothermia treatment differs from other hypothermia therapy in four major sections: Brain Injury Mechanism, Pathophysiology of Hypothermia, Basic Research of Hypothermia Treatment, and Clinical Studies of Brain Hypothermia. The book is a valuable source for practitioners and researchers in neurosurgery and neurology and in critical care and emergency medicine.

Hibernation and Torpor in Mammals and Birds

Hibernation and Torpor in Mammals and Birds
Author: Charles P Lyman
Publisher: Elsevier
Total Pages: 332
Release: 2013-07-10
Genre: Nature
ISBN: 0323138241

Hibernation and Torpor in Mammals and Birds explores the physiological factors that control hibernation and torpor in birds and mammals. This text covers topics ranging from metabolism in hibernation to the role of endocrines, respiration and acid-base state in hibernation, and theories of hibernation. This book is comprised of 14 chapters and begins with an overview of some clear-cut definitions and why mammals and birds hibernate. The reader is then introduced to the variations from euthermia that have been observed among birds and mammals. To give some structure to this listing, the approach is phylogenetic, starting with the birds and proceeding through the primitive to the more advanced mammals. Subsequent chapters explains the process of entering hibernation and the hibernating state, itself; capability of a species in natural hibernation to arouse from that state using self-generated heat; physiological changes at the start of a spontaneous arousal; and physiological mechanisms underlying the ability of hibernators to rewarm. Consideration is also given to intermediary metabolism in hibernation, cold adaptation of metabolism in hibernators, and the response of hibernators to various extrinsic influences such as neoplastic growth, radiation injury, and parasitism and symbionts. This book will be of interest to students and researchers in fields ranging from zoology to physiology and biophysics.

Micro-, Meso- and Macro-Dynamics of the Brain

Micro-, Meso- and Macro-Dynamics of the Brain
Author: György Buzsáki
Publisher: Springer
Total Pages: 181
Release: 2016-05-02
Genre: Medical
ISBN: 3319288024

This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The individual chapters cover several fascinating facets of contemporary neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Each of these topics require appropriate levels of analyses with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks, supplemented by models and theories to explain how different levels of brain dynamics interact with each other and how the failure of such interactions results in neurologic and mental disease. While such complex questions cannot be answered exhaustively by a dozen or so chapters, this volume offers a nice synthesis of current thinking and work-in-progress on micro-, meso- and macro- dynamics of the brain.

Oil on the Brain

Oil on the Brain
Author: Lisa Margonelli
Publisher: Crown
Total Pages: 351
Release: 2008-02-12
Genre: Business & Economics
ISBN: 0767916972

Oil on the Brain is a smart, surprisingly funny account of the oil industry—the people, economies, and pipelines that bring us petroleum, brilliantly illuminating a world we encounter every day. Americans buy ten thousand gallons of gasoline a second, without giving it much of a thought. Where does all this gas come from? Lisa Margonelli’s desire to learn took her on a one-hundred thousand mile journey from her local gas station to oil fields half a world away. In search of the truth behind the myths, she wriggled her way into some of the most off-limits places on earth: the Strategic Petroleum Reserve, the New York Mercantile Exchange’s crude oil market, oil fields from Venezuela, to Texas, to Chad, and even an Iranian oil platform where the United States fought a forgotten one-day battle. In a story by turns surreal and alarming, Margonelli meets lonely workers on a Texas drilling rig, an oil analyst who almost gave birth on the NYMEX trading floor, Chadian villagers who are said to wander the oil fields in the guise of lions, a Nigerian warlord who changed the world price of oil with a single cell phone call, and Shanghai bureaucrats who dream of creating a new Detroit. Deftly piecing together the mammoth economy of oil, Margonelli finds a series of stark warning signs for American drivers.

Rhythms of the Brain

Rhythms of the Brain
Author: G. Buzsáki
Publisher: Oxford University Press
Total Pages: 465
Release: 2011
Genre: Medical
ISBN: 0199828237

Studies of mechanisms in the brain that allow complicated things to happen in a coordinated fashion have produced some of the most spectacular discoveries in neuroscience. This book provides eloquent support for the idea that spontaneous neuron activity, far from being mere noise, is actually the source of our cognitive abilities. It takes a fresh look at the coevolution of structure and function in the mammalian brain, illustrating how self-emerged oscillatory timing is the brain's fundamental organizer of neuronal information. The small-world-like connectivity of the cerebral cortex allows for global computation on multiple spatial and temporal scales. The perpetual interactions among the multiple network oscillators keep cortical systems in a highly sensitive "metastable" state and provide energy-efficient synchronizing mechanisms via weak links. In a sequence of "cycles," György Buzsáki guides the reader from the physics of oscillations through neuronal assembly organization to complex cognitive processing and memory storage. His clear, fluid writing-accessible to any reader with some scientific knowledge-is supplemented by extensive footnotes and references that make it just as gratifying and instructive a read for the specialist. The coherent view of a single author who has been at the forefront of research in this exciting field, this volume is essential reading for anyone interested in our rapidly evolving understanding of the brain.

The Human Hypothalamus

The Human Hypothalamus
Author: Gabriel I. Uwaifo
Publisher: Springer Nature
Total Pages: 535
Release: 2020-12-24
Genre: Medical
ISBN: 3030621871

The hypothalamus is an anatomically small but functionally important part of the brain. In functional and pathophysiological terms, the hypothalamus represents the intersection of several areas of clinical and medical expertise. The human hypothalamus can be astutely referred to as the crossroad of endocrinology, psychiatry, neurology and neurosurgery. Because of its involvement in myriad physiologic functions and the varied ways disorders involving it can manifest, hypothalamic disease can initially come to medical attention in widely disparate settings and with widely different clinicians. Therefore, the detection and proper care of hypothalamic dysfunction and disease often requires carefully coordinated multidisciplinary care. This volume fills a significant void in the medical professional community, comprehensively presenting the scope of hypothalamic structure, function, dysfunction and disease to cater to the various clinical, teaching and research professionals that have a stake in this part of the human brain. This text captures in one place all the information that practicing clinicians, clinician scientists, and researchers need to be adequately informed about various aspects of the hypothalamus in all its complexity. It is comprehensive and broad in scope so that it provides relevant reference information for the wide range of professionals involved in the pre- and post-mortem detection, diagnosis, characterization, care and management of various hypothalamic disorders and diseases in addition to providing a sound anatomic and physiologic foundation of the normal human hypothalamus. The Human Hypothalamus can be used to differing degrees by medical professionals and students alike, finding utility for interested general clinicians, medical school and allied health professional teaching faculty as well as subspecialists in domains as wide as neurosurgery, neuroendocrinology, clinical psychiatry and neuro-oncology.

Pituitary Adenylate Cyclase-Activating Polypeptide

Pituitary Adenylate Cyclase-Activating Polypeptide
Author: Hubert Vaudry
Publisher: Springer Science & Business Media
Total Pages: 432
Release: 2003
Genre: Medical
ISBN: 9781402073069

Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.

Life in the Cold

Life in the Cold
Author: Gerhard Heldmaier
Publisher: Springer Science & Business Media
Total Pages: 568
Release: 2000-08-07
Genre: Medical
ISBN: 9783540674108

This book gives an up-to-date account of the current knowledge of cold adaptation in animals, including phenomena like hibernation, daily torpor, thermoregulation and thermogenesis, metabolic regulation, freeze tolerance, anaerobiosis, metabolic depression and related processes. For the next four years - until the 12th International Hibernation Symposium - it will serve as a state-of-the-art reference source for every scientist and graduate student working in these areas of physiology and zoology.

Ecological Physiology of Daily Torpor and Hibernation

Ecological Physiology of Daily Torpor and Hibernation
Author: Fritz Geiser
Publisher: Springer Nature
Total Pages: 326
Release: 2021-08-23
Genre: Science
ISBN: 3030755258

This book provides an in-depth overview on the functional ecology of daily torpor and hibernation in endothermic mammals and birds. The reader is well introduced to the physiology and thermal energetics of endothermy and underlying different types of torpor. Furthermore, evolution of endothermy as well as reproduction and survival strategies of heterothermic animals in a changing environment are discussed. Endothermic mammals and birds can use internal heat production fueled by ingested food to maintain a high body temperature. As food in the wild is not always available, many birds and mammals periodically abandon energetically costly homeothermic thermoregulation and enter an energy-conserving state of torpor, which is the topic of this book. Daily torpor and hibernation (multiday torpor) in these heterothermic endotherms are the most effective means for energy conservation available to endotherms and are characterized by pronounced temporal and controlled reductions in body temperature, energy expenditure, water loss, and other physiological functions. Hibernators express multiday torpor predominately throughout winter, which substantially enhances winter survival. In contrast, daily heterotherms use daily torpor lasting for several hours usually during the rest phase, some throughout the year. Although torpor is still widely considered to be a specific adaptation of a few cold-climate species, it is used by many animals from all climate zones, including the tropics, and is highly diverse with about 25-50% of all mammals, but fewer birds, estimated to use it. While energy conservation during adverse conditions is an important function of torpor, it is also employed to permit or facilitate energy-demanding processes such as reproduction and growth, especially when food supply is limited. Even migrating birds enter torpor to conserve energy for the next stage of migration, whereas bats may use it to deal with heat. Even though many heterothermic species will be challenged by anthropogenic influences such as habitat destruction, introduced species, novel pathogens and specifically global warming, not all are likely to be affected in the same way. In fact it appears that opportunistic heterotherms because of their highly flexible energy requirements, ability to limit foraging and reduce the risk of predation, and often pronounced longevity, may be better equipped to deal with anthropogenic challenges than homeotherms. In contrast strongly seasonal hibernators, especially those restricted to mountain tops, and those that have to deal with new diseases that are difficult to combat at low body temperatures, are likely to be adversely affected. This book addresses researchers and advanced students in Zoology, Ecology and Veterinary Sciences.