In 2000 the American Psychological Association, in an important attempt to bring religious issues and traditions to the attention of psychotherapists, included in its Handbook of Psychotherapy and Religious Diversity a chapter on psychotherapy with Eastern Orthodox Christians. This chapter discusses the pivotal efforts of Metropolitan Hierotheos and Archbishop Chrysostomos to bring together the ancient teachings of the Christian East with the science of modern psychology. In this work, the relationship between psychology and religion is analyzed. It presents an analysis of the teachings of the Eastern Church Fathers on the world, man, and the psychological aspects of the union of man with God. Archbishop Chrysostomos works into his presentation the extent of his own research as well as the writings of Metropolitan Hierotheos, which include attempts to evaluate the place, significance, and the effectiveness of Orthodox psychotherapy in secular psychotherapy and its application in the clinical setting.