There are notorious health inequalities in Latin America and the Caribbean. A series of factors limit access to timely and quality medical care: scarcity of human resources, infrastructure, facilities and medicine, as well as low family incomes, physical and cultural distance between supply provided by the public sector and the population requiring care. Income levels, place of residence and ethnic origins are therefore variables that shape vulnerability and exclusion of millions of households throughout the region. This situation is accompanied by changes in health demand structure stemming from the fast speed of population aging and urban growth, especially in intermediate cities. On the other hand, increasing movement of people between countries, especially in border areas, poses the challenge of integrated strategies for epidemiological surveillance and healthcare. This situation is exacerbated by the rising cost of medical care, due -- among other reasons -- to the higher cost of health related technologies (medicine and equipment), and more commonplace chronic diseases because of the increasing number of older people. This scenario implies important challenges for the development of State policies and strategies that must include decisions regarding the incorporation of information and communication technologies (ICTs). The potential of these policies and strategies for reducing access limitations, improving efficiency in the health sector and in the quality of care and patient safety, are some of the elements that must be considered in order to decidedly face the difficulties and resistance that other sectors have already tackled. Major changes and increasing improvements for ICTs, as well as the breakneck development of bioengineering and technological convergence are changing the way we can work around the issue of health. The possible application of such technological innovation encompasses many, if not all activities related to health care, administration and education, offering opportunities to both increase coverage and improve the quality of care, as well as health system effectiveness and efficiency. The concept of electronic health (e-health) is used herein to encompass the multiple potential applications of ICTs in this field, regardless of whether they are aimed at health sector authorities, organizations providing care and health professionals, or used as customized systems for patients and citizens in general. This concept includes applications ranging from electronic medical records and various types of telemedicine to health portals and hospital management systems, among others. This basically refers to everything that uses ICTs in order to improve health actions in the sphere of prevention, diagnosis, treatment, monitoring and management. However, limited institutional progress has been made despite several electronic health initiatives being implemented throughout the region. Consequently, most of these projects have limited scope and are not properly integrated into health policies or national ICT strategies. This document starts by identifying and describing the several benefits expected as a result of incorporating ICTs in health and goes on to summarize present and future challenges for health policies, especially inasmuch as the most vulnerable populations are concerned. Thirdly, the document showcases global progress made in several applications, strategies implemented and difficulties faced in some developed and LAC countries. The document finishes with generic proposals for the formulation of policies and strategies to be considered and adapted by countries throughout the region.