Recent studies, including those by the investigators, have shown that higher cement replacement percentages -- even up to 75 percent -- can result in excellent concrete in terms of both strength and durability. Referred to as high-volume fly ash (HVFA) concrete, this material offers a viable alternative to traditional portland cement concrete and is significantly more sustainable. However, HVFA concrete is not without its problems. At all replacement rates, fly ash generally slows down the setting time and hardening rates of concrete at early ages, especially under cold weather conditions, and when less reactive fly ashes are used. Furthermore, with industrial by-products, some variability in physical and chemical characteristics will normally occur, not only between power plants but also within the same plant. Consequently, to achieve the benefits of HVFA concrete, guidelines are needed for its proper application in bridges, roadways, culverts, retaining walls, and other transportation-related infrastructure components. The objective of this research was to design, test, and evaluate HVFA concrete mixtures. The study focused on the hardened properties of HVFA concrete containing aggregates and fly ash indigenous to the state of Missouri and developed guidelines on its use in infrastructure elements for MoDOT.