Mathematical science is the human recognition on the evolution laws of things that we can understand with the principle of logical consistency by mathematics, i.e., mathematical reality. So, is the mathematical reality equal to the reality of thing? The answer is not because there always exists contradiction between things in the eyes of human, which is only a local or conditional conclusion. Such a situation enables us to extend the mathematics further by combinatorics for the reality of thing from the local reality and then, to get a combinatorial reality of thing. This is the combinatorial conjecture for mathematical science, i.e., CC conjecture that I put forward in my postdoctoral report for Chinese Acade- my of Sciences in 2005, namely any mathematical science can be reconstructed from or made by combinatorialization. After discovering its relation with Smarandache multi-spaces, it is then be applied to generalize mathematics over 1-dimensional topological graphs, namely the mathematical combinatorics that I promoted on science internationally for more than 20 years. This paper surveys how I proposed this conjecture from combinatorial topology, how to use it for characterizing the non-uniform groups or contradictory systems and furthermore, why I introduce the continuity ow GL as a mathematical element, i.e., vectors in Banach space over topological graphs with operations and then, how to apply it to generalize a few of important conclusions in functional analysis for providing the human recognition on the reality of things, including the subdivision of substance into elementary particles or quarks in theoretical physics with a mathematical supporting.