This book explores the growing field of bio-design through interdisciplinary creative practice. The volume illustrates a range of experimental working techniques while offering a foundational understanding of lab practice principles. The book highlights the myriad of opportunities presented by microorganisms that have reshaped the planet and made it habitable. The book provides an account of the creation of living materials from the point of view of an architectural design practitioner. The transition from traditional design practice to laboratory investigation is captured, highlighting strategies of creating partnerships across a range of fields. The book demonstrates laboratory methods and ways of investigating the development of living materials and celebrates the growing body of practitioners, scientists, activists and anthropologists who are reimagining new strategies for addressing contemporary environmental challenges. Designer's Guide to Lab Practice looks at ways in which integrating living components with needs of their own would not only help offset the environmental impact that we have on our planet but could also create a closer relationship with nature. It is a working manual as well as a guide to emerging practitioners seeking to transition into a field that is yet to be defined and that offers the promise of a new era of human habitat making as a direct response to the looming ecological crisis.