Genomic Imprinting
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| Author | : Renato Paro |
| Publisher | : Springer Nature |
| Total Pages | : 215 |
| Release | : 2021-03-23 |
| Genre | : Science |
| ISBN | : 3030686701 |
This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
| Author | : R. Ohlsson |
| Publisher | : Cambridge University Press |
| Total Pages | : 188 |
| Release | : 1995-12-14 |
| Genre | : Medical |
| ISBN | : 9780521472432 |
This significant new publication on genomic or parental imprinting has been prepared by an outstanding team of international authorities. Genomic imprinting results in the preferential expression of one allele, depending on the parent of origin. It is associated with several disease syndromes in humans. Interest in this area has expanded rapidly from the time when it was first recognised that some important hereditary characterisitics were not adequately explained by the Mendelian laws of inheritance. The chapters cover a wealth of material to help explain not only the mechanisms of genomic imprinting but its biological and medical consequences.
| Author | : Rolf Ohlsson |
| Publisher | : Springer |
| Total Pages | : 352 |
| Release | : 1999-03-08 |
| Genre | : Medical |
| ISBN | : |
This book provides an unrivalled in-depth treatise of genomic imprinting, a phenomenon which plays a vital role in many biological processes in developmental biology, evolution and human diseases and genetics. The reason for this broad range of influence derives from the fact that genomic imprinting shields a number of important genes from the full effects of Mendelian inheritance. The importance of this surprising observation, which was discovered less than two decades ago, has been only slowly recognized. The reason for this may be that genomic imprinting is a difficult concept to understand. This book aims at providing interesting, entertaining and detailed information for any scientist, irrespective of their particular field of study.
| Author | : Ettore Olmo |
| Publisher | : Birkhäuser |
| Total Pages | : 339 |
| Release | : 2013-03-09 |
| Genre | : Medical |
| ISBN | : 3034884842 |
Chromosomes Today, Volume 13 includes the plenary lectures presented at the 13th International Chromosome Conference, covering the most recent advances in the studies on chromosomes. The contributions in this volume were presented by some of the world's leaders in cytogenetic and molecular research and outline the present status of knowledge on the composition, structure, function and evolution of chromosomes, including, among others, the advancement of the human genome project. The use of cytogenetic studies has greatly increased in the last few years, resulting in a progressive improvement in the available methods that has consequently allowed a more detailed analysis of the molecular organization of eukaryotic chromosomes and a precise in situ localisation of specific gene sequences. This volume of Chromosomes Today provides up-to-date information regarding the topics at the forefront of chromosome research: genetic regulation, imprinting, DNA duplication, meiotic pairing, and the regulation of the...
| Author | : Trygve O Tollefsbol |
| Publisher | : Academic Press |
| Total Pages | : 684 |
| Release | : 2017-07-10 |
| Genre | : Science |
| ISBN | : 0128054778 |
Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials
| Author | : Jon F. Wilkins |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 141 |
| Release | : 2009-10-01 |
| Genre | : Medical |
| ISBN | : 0387775765 |
The goal of this book is neither to provide a basic introduction to imprinting, nor to provide a comprehensive survey of the current state of the field. Rather, the book covers more recent advances, drawing attention to the emerging subtleties and complexities associated with imprinted genes. Genomic imprinting refers to a recently discovered phenomenon in which the expression pattern of an allele depends on whether that allele was inherited from the mother or the father.
| Author | : Andrew Ward |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 381 |
| Release | : 2008-02-02 |
| Genre | : Medical |
| ISBN | : 1592592112 |
Genomic imprinting is the process by which gene activity is regulated according to parent of origin. Usually, this means that either the maternally inherited or the paternally inherited allele of a gene is expressed while the opposite allele is repressed. The phenomenon is largely restricted to mammals and flowering plants and was first recognized at the level of whole genomes. Nuclear transplantation experiments carried out in mice in the late 1970s established the non-equivalence of the maternal and paternal genomes in mammals, and a similar conclusion was drawn from studies of interploidy crosses of flowering plants that extend back to at least the 1930s. Further mouse genetic studies, involving animals carrying balanced translocations (reviewed in Chapter 3), indicated that imprinted genes were likely to be widely scattered and would form a minority within the mammalian genome. The first imprinted genes were identified in the early 1990s; over forty are now known in mammals and the list continues steadily to expand.
| Author | : David Haig |
| Publisher | : Rutgers University Press |
| Total Pages | : 244 |
| Release | : 2002 |
| Genre | : Science |
| ISBN | : 9780813530277 |
Genomic imprinting allows scientists to trace genes to the parent of origin. This volume presents a collection of 13 papers by David Haig (organisimic and evolutionary biology, Harvard U.) on genomic imprinting. He argues that our paternally and maternally active genes do not work in cooperation with each other and in fact are in competition. Each paper is followed by commentary by the author, providing background information and discussing developments since its publication. Annotation copyrighted by Book News Inc., Portland, OR.
| Author | : Eric Engel |
| Publisher | : John Wiley & Sons |
| Total Pages | : 303 |
| Release | : 2004-03-24 |
| Genre | : Medical |
| ISBN | : 0471459135 |
Eric Engel and Stylianos Antonarakis have written the most authoritative and vital reference on molecular and clinical aspects of uniparental disomy (UPD) and genomic imprinting to date. Genomic Imprinting and Uniparental Disomy in Medicine features comprehensive overviews of a multitude of genetic disorders linked to UPD, with a strong emphasis on clinical consequences. This book will provide readers with the tools necessary to identify and treat diseases associated with nontraditional chromosomal inheritance. Genomic Imprinting and Uniparental Disomy in Medicine features handy tables summarizing clinical phenotypes and chromosomal involvement in UPD, as well as clear illustrations on imprinting mechanisms and diagnostic testing. This authoritative, completely up-to-date practical reference will be useful for any clinical geneticist, genetic counselor, physician, or researcher encountering patients with such disorders or studying complex disease mechanisms.
| Author | : Philippe Jeanteur |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 284 |
| Release | : 2008-09-10 |
| Genre | : Science |
| ISBN | : 9783540852360 |
Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence. This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility. The other one deals with parental genomic imprinting, a process which allows to express a few selected genes from only one of the parental allele while extinguishing the other.
