Genetics And Teratology
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Teratology
Author | : C.L. Berry |
Publisher | : Springer Science & Business Media |
Total Pages | : 246 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642661726 |
In the fifteen years since the thalidomide disaster teratology has become a science in its own right, distinct from its progenitors, experimental embryology and develop mental biology, but bearing many of the familiar features of both parents. In this growth period there have been contributions from many different scientific disciplines as diverse as molecular biology and obstetrics, which have united in the field of study of congenital malformations. Scientists in academic departments, government research institutes and industrial pharmacology have all explored ways of evaluating the potential of drugs and chem icals to damage the embryo; strict methods of screening for teratogenicity have be come mandatory in most parts of the world. Despite a wealth of basic information in the fields of genetics and embryology, there is little concrete knowledge of the causal mechanisms of malformation in Man, and even less concerning the relevance to Man of those laboratory and animal tests which decide the fate of potentially useful drugs. It is timely, therefore, that in 1975 a group of young and active sci entists and clinicians concerned with the broader implications of teratology should review the past and look to the future of this emerging speciality. In this volume the editors have blended the opinions of teratologists; their message presages change in many of the old and accepted areas of investigative teratology.
Catalog of Teratogenic Agents
Author | : Thomas H. Shepard |
Publisher | : JHU Press |
Total Pages | : 564 |
Release | : 2004 |
Genre | : Teratogenic agents |
ISBN | : 9780801879531 |
Links information on experimental teratogenic agents with the congenital defects in human beings.
The Program of the Genetics and Teratology Branch of the Center for Research for Mothers and Children
Author | : Center for Research for Mothers and Children (U.S.). Genetics and Teratology Branch |
Publisher | : |
Total Pages | : 132 |
Release | : 1989 |
Genre | : |
ISBN | : |
Health Risks of Radon and Other Internally Deposited Alpha-Emitters
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 623 |
Release | : 1988-02-01 |
Genre | : Science |
ISBN | : 0309037891 |
This book describes hazards from radon progeny and other alpha-emitters that humans may inhale or ingest from their environment. In their analysis, the authors summarize in one document clinical and epidemiological evidence, the results of animal studies, research on alpha-particle damage at the cellular level, metabolic pathways for internal alpha-emitters, dosimetry and microdosimetry of radionuclides deposited in specific tissues, and the chemical toxicity of some low-specific-activity alpha-emitters. Techniques for estimating the risks to humans posed by radon and other internally deposited alpha-emitters are offered, along with a discussion of formulas, models, methods, and the level of uncertainty inherent in the risk estimates.
The Encyclopedia of Genetic Disorders and Birth Defects
Author | : James Wynbrandt |
Publisher | : Infobase Publishing |
Total Pages | : 705 |
Release | : 2010-05-12 |
Genre | : Juvenile Nonfiction |
ISBN | : 1438120958 |
Presents information on congenital birth defects, giving the name, known or suspect cause and brief description as well as available treatments where applicable.
Molecular Insights Into Development In Humans: Studies In Normal Development And Birth Defects
Author | : Moyra Smith |
Publisher | : World Scientific Publishing Company |
Total Pages | : 263 |
Release | : 2014-11-20 |
Genre | : Medical |
ISBN | : 9814630608 |
The aim and scope of this book is to review current information on human development and processes of differentiation that have benefited from breakthrough analyses in stem cell biology, elucidation of genome and gene architecture and aspects of regulation of gene expression, analysis of signaling systems and transcription factor actions.Insights into actions of specific genes and their roles in development have been gathered through studies in patients with specific birth defects, including congenital malformations, metabolic defects and functional impairments.The book is organized into three sections, the first dealing with aspects of genomics, gene structure and regulation, analysis of signaling and function of specific organelles. The second section deals with molecular aspects of development of specific organs and structures such as, bone, face, brain, heart, liver, pancreas, kidney. The last section deals with specific malformations and tumors that provide insight into regulation of growth. Environmental factors that impact growth and development are also covered.
Issues and Reviews in Teratology
Author | : H. Kalter |
Publisher | : Springer |
Total Pages | : 352 |
Release | : 1990-02-28 |
Genre | : Gardening |
ISBN | : |
Why Efforts to Expand the Meaning of "Teratogen" Are Unacceptable Disagreement about nomenclature in teratology is not new. Dissent even about the very fabric of the discipline-what congenital malformations consist of-has often been voiced. Time, instead of resolving such diffi culties, has sometimes worsened them. For example, in the past it was agreed that congenital malforma tions are abnormalities of structure present at birth, but differences of opinion concerning where the line between normal and abnormal was to be drawn prevailed. It was obvious that, in order to discover the causes of congenital malformations and cast strategies for their prevention, it would be necessary to have knowledge of the baseline of their frequency, and that this required uniformity of definition of terms. Since malfor mations of primary social concern are those having grave outcomes (and are, paradoxically, also the commonest ones), it is logical that such condi tions were the first consideration of investigators and were the defects whose frequency was considered to comprise the required baseline.