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| Author | : J. W. Van Ooijen |
| Publisher | : Cambridge University Press |
| Total Pages | : 171 |
| Release | : 2013-08-08 |
| Genre | : Mathematics |
| ISBN | : 1107013216 |
A concise introduction to genetic linkage map construction for biological researchers, combining theory with practical exercises and problem-solving tips.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 128 |
| Release | : 1988-01-01 |
| Genre | : Science |
| ISBN | : 0309038405 |
There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
| Author | : R.L. Phillips |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 508 |
| Release | : 2013-03-14 |
| Genre | : Science |
| ISBN | : 9401598150 |
With the new techniques described in this volume, a new gene can be placed on the linkage map within only a few days. Leading researchers have updated the earlier edition to include the latest versions of DNA-based marker maps for a variety of important crops.
| Author | : David Siegmund |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 337 |
| Release | : 2007-05-27 |
| Genre | : Medical |
| ISBN | : 0387496866 |
This book details the statistical concepts used in gene mapping, first in the experimental context of crosses of inbred lines and then in outbred populations, primarily humans. It presents elementary principles of probability and statistics, which are implemented by computational tools based on the R programming language to simulate genetic experiments and evaluate statistical analyses. Each chapter contains exercises, both theoretical and computational, some routine and others that are more challenging. The R programming language is developed in the text.
| Author | : J. W. Van Ooijen |
| Publisher | : Cambridge University Press |
| Total Pages | : 171 |
| Release | : 2013-08-08 |
| Genre | : Science |
| ISBN | : 1107292301 |
Genetic linkage maps are an increasingly important tool in both fundamental and applied research, enabling the study and deployment of genes that determine important biological traits. This concise introduction to genetic mapping in species with disomic inheritance enables life science graduate students and researchers to use mapping software to produce more reliable results. After a brief refresher on meiosis and genetic recombination, the steps in the map construction procedure are described, with explanations of the computations involved. The emphasis throughout is on the practical application of the methods described; detailed mathematical formulae are avoided and exercises are included to help readers consolidate their understanding. A chapter on recognising and solving problems provides valuable guidance for dealing with real-life situations. An extensive chapter dedicated to the more complex situation of outbreeding species offers a unique insight into the approach required for many economically important and model species, both plants and animals.
| Author | : Karl W. Broman |
| Publisher | : Springer |
| Total Pages | : 400 |
| Release | : 2011-12-02 |
| Genre | : Science |
| ISBN | : 9781461417088 |
Comprehensive discussion of QTL mapping concepts and theory Detailed instructions on the use of the R/qtl software, the most featured and flexible software for QTL mapping Two case studies illustrate QTL analysis in its entirety
| Author | : Christian R. Landry |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 358 |
| Release | : 2013-11-25 |
| Genre | : Science |
| ISBN | : 9400773471 |
Researchers in the field of ecological genomics aim to determine how a genome or a population of genomes interacts with its environment across ecological and evolutionary timescales. Ecological genomics is trans-disciplinary by nature. Ecologists have turned to genomics to be able to elucidate the mechanistic bases of the biodiversity their research tries to understand. Genomicists have turned to ecology in order to better explain the functional cellular and molecular variation they observed in their model organisms. We provide an advanced-level book that covers this recent research and proposes future development for this field. A synthesis of the field of ecological genomics emerges from this volume. Ecological Genomics covers a wide array of organisms (microbes, plants and animals) in order to be able to identify central concepts that motivate and derive from recent investigations in different branches of the tree of life. Ecological Genomics covers 3 fields of research that have most benefited from the recent technological and conceptual developments in the field of ecological genomics: the study of life-history evolution and its impact of genome architectures; the study of the genomic bases of phenotypic plasticity and the study of the genomic bases of adaptation and speciation.
| Author | : Florian Frommlet |
| Publisher | : Springer |
| Total Pages | : 232 |
| Release | : 2016-02-12 |
| Genre | : Computers |
| ISBN | : 1447153103 |
This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.
| Author | : Jurg Ott |
| Publisher | : JHU Press |
| Total Pages | : 418 |
| Release | : 1999-04-16 |
| Genre | : Medical |
| ISBN | : 9780801861406 |
Introduction and basic genetic principles; Genetic loci genetic polymorphisms; Aspects of statistical inference; Basics of linkage analysis; The informativeness of family data; Multipoint linkage analysis; Penetrance; Quantitative phenotypes; Numerical and computerized methods; Variability of the recombination fraction; Inconsistencies; Linkage analysis with mendelian disease loci; Nonparametric methods; Two-locus inheritance; Complex traits.
| Author | : Hans D. Daetwyler |
| Publisher | : Frontiers Media SA |
| Total Pages | : 173 |
| Release | : 2020-01-28 |
| Genre | : |
| ISBN | : 288963390X |
