Analysis of Human Genetic Linkage

Analysis of Human Genetic Linkage
Author: Jurg Ott
Publisher: JHU Press
Total Pages: 418
Release: 1999-04-16
Genre: Medical
ISBN: 9780801861406

Introduction and basic genetic principles; Genetic loci genetic polymorphisms; Aspects of statistical inference; Basics of linkage analysis; The informativeness of family data; Multipoint linkage analysis; Penetrance; Quantitative phenotypes; Numerical and computerized methods; Variability of the recombination fraction; Inconsistencies; Linkage analysis with mendelian disease loci; Nonparametric methods; Two-locus inheritance; Complex traits.

Mapping and Sequencing the Human Genome

Mapping and Sequencing the Human Genome
Author: National Research Council
Publisher: National Academies Press
Total Pages: 128
Release: 1988-01-01
Genre: Science
ISBN: 0309038405

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Genetic Mapping in Experimental Populations

Genetic Mapping in Experimental Populations
Author: J. W. Van Ooijen
Publisher: Cambridge University Press
Total Pages: 171
Release: 2013-08-08
Genre: Mathematics
ISBN: 1107013216

A concise introduction to genetic linkage map construction for biological researchers, combining theory with practical exercises and problem-solving tips.

Exploring the Biological Contributions to Human Health

Exploring the Biological Contributions to Human Health
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 287
Release: 2001-07-02
Genre: Medical
ISBN: 0309132975

It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.

Genetics for Surgeons

Genetics for Surgeons
Author: Patrick John Morrison
Publisher: Remedica
Total Pages: 237
Release: 2005
Genre: Medical
ISBN: 1901346692

Morrison (human genetics, University of Ulster, UK) and Spence (biomedical science, University of Ulster, UK) offer an accessible reference on the genetic disorders that surgeons can expect to meet in general surgical practice. Written in non-technical language, with a glossary, list of abbreviations, and color and b&w photos and medical images, the book supplies an introduction to the nomenclature and technology of molecular biology, and will be a useful starting point for those who wish to extend their knowledge. Annotation :2005 Book News, Inc., Portland, OR (booknews.com).

DNA-Based Markers in Plants

DNA-Based Markers in Plants
Author: R.L. Phillips
Publisher: Springer Science & Business Media
Total Pages: 508
Release: 2013-03-14
Genre: Science
ISBN: 9401598150

With the new techniques described in this volume, a new gene can be placed on the linkage map within only a few days. Leading researchers have updated the earlier edition to include the latest versions of DNA-based marker maps for a variety of important crops.

Molecular Genetics of Sex Determination

Molecular Genetics of Sex Determination
Author: Stephen S. Wachtel
Publisher: Academic Press
Total Pages: 544
Release: 1994
Genre: Medical
ISBN:

The text is organized into two parts. Firstly, it reviews the basic biology of sex determination and summarizes ground-breaking work in mouse, marsupial and Drosophila systems. Secondly, it covers current human genetics, clinical studies and the syndromes of abnormal sex differentiation.

The Genetics of Cancer

The Genetics of Cancer
Author: B.A. Ponder
Publisher: Springer Science & Business Media
Total Pages: 222
Release: 2012-12-06
Genre: Medical
ISBN: 9401106770

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.