Genetic Instabilities And Hereditary Neurological Diseases
Download Genetic Instabilities And Hereditary Neurological Diseases full books in PDF, epub, and Kindle. Read online free Genetic Instabilities And Hereditary Neurological Diseases ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author | : Robert D. Wells |
Publisher | : Elsevier |
Total Pages | : 783 |
Release | : 2011-10-13 |
Genre | : Science |
ISBN | : 0080463770 |
Genetic Instabilities and Neurological Diseases covers DNA repeat instability and neurological disorders, covering molecular mechanisms of repeat expansion, pathogenic mechanisms, clinical phenotype, parental gender effects, genotype-phenotype correlation, and diagnostic applications of the molecular data. This updated edition provides updates of these repeat expansion mutations, including the addition of many new chapters, and old chapters rewritten as extensions of the previous edition. This book is an invaluable reference source for neuroscientists, geneticists, neurologists, molecular biologists, genetic counsellors and students. - Contributions by most of the principal research teams in the area, edited by world-renowned leaders - Lays the background for future investigations on related diseases
Author | : Robert D. Wells |
Publisher | : |
Total Pages | : 886 |
Release | : 1998 |
Genre | : Medical |
ISBN | : |
This book represents the first authoritative review of all neurological diseases related to repeat expansions. Some of the diseases covered in this volume include fragile X syndrome, spino and bulbar muscular atrophy, myotonic dystrophy, spinocerebellar ataxia type 1 and type 7, Huntingtons disease, and Friedreichs ataxia. The book describes investigations into the underlying molecular mechanisms responsible for these syndromes. For students and researchers alike, Genetic Instabilities and Hereditary Neurological Diseases serves as a comprehensive treatise covering many aspects of all neurological diseases.
Author | : Alan J. Sinclair |
Publisher | : John Wiley & Sons |
Total Pages | : 3453 |
Release | : 2012-03-13 |
Genre | : Medical |
ISBN | : 1119954142 |
This new edition of the comprehensive and renowned textbook Principles and Practice of Geriatric Medicine offers a fully revised and updated review of geriatric medicine. It covers the full spectrum of the subject, features 41 new chapters, and provides up-to-date, evidence-based, and practical information about the varied medical problems of ageing citizens. The three editors, from UK, USA and France, have ensured that updated chapters provide a global perspective of geriatric medicine, as well as reflect the changes in treatment options and medical conditions which have emerged since publication of the 4th edition in 2006. The book includes expanded sections on acute stroke, dementia, cardiovascular disease, and respiratory diseases, and features a new section on end-of-life care. In the tradition of previous editions, this all-encompassing text continues to be a must-have text for all clinicians who deal with older people, particularly geriatric medical specialists, gerontologists, researchers, and general practitioners. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from Google Play or the MedHand Store. Praise for the 4th edition: "...an excellent reference for learners at all clinical and preclinical levels and a useful contribution to the geriatric medical literature." —Journal of the American Medical Association, November 2006 5th edition selected for 2012 Edition of Doody's Core TitlesTM
Author | : Jean-Louis Serre |
Publisher | : John Wiley & Sons |
Total Pages | : 270 |
Release | : 2007-01-11 |
Genre | : Science |
ISBN | : 0470870265 |
Recent developments within molecular biology and genetic engineering have led to huge advances and changes within the biological sciences especially within the field of human genetics. Diagnostic Techniques in Genetics offers an important overview of how DNA or RNA technology may be applied to a large set of genetic diagnoses. The first part of the book focuses on DNA/RNA applications and includes many of the latest developments in the field combined with routine procedures of genetic diagnoses, for example cloning and sequencing DNA. The DNA applications presented in the first chapter are then each applied to a specific kind of genetic diagnosis and the text concludes with a chapter devoted to population genetics. First published in French by Dunod in 2002, this book is an excellent reference for students taking courses in molecular biology, medicine and medical genetics. It is also a useful introduction for postgraduate students and researchers in the field who require a general overview of genetic diagnoses.
Author | : Mario Manto |
Publisher | : Cambridge University Press |
Total Pages | : 620 |
Release | : 2002 |
Genre | : Medical |
ISBN | : 9780521771566 |
The first comprehensive text on the cerebellum and its disorders for many years.
Author | : Marie-Francoise Chesselet |
Publisher | : Springer Science & Business Media |
Total Pages | : 416 |
Release | : 2000-10-19 |
Genre | : Medical |
ISBN | : 1592590063 |
With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.
Author | : Michiya Fujiki |
Publisher | : Buy this from MDPI Books |
Total Pages | : 318 |
Release | : 2019-11-14 |
Genre | : Science |
ISBN | : 3039217224 |
In 1978, Fred Hoyle proposed that interstellar comets carrying several viruses landed on Earth as part of the panspermia hypotheses. With respect to life, the origin of homochirality on Earth has been the greatest mystery because life cannot exist without molecular asymmetry. Many scientists have proposed several possible hypotheses to answer this long-standing L-D question. Previously, Martin Gardner raised the question about mirror symmetry and broken mirror symmetry in terms of the homochirality question in his monographs (1964 and 1990). Possible scenarios for the L-D issue can be categorized into (i) Earth and exoterrestrial origins, (ii) by-chance and necessity mechanisms, and (iii) mirror-symmetrical and non-mirror-symmetrical forces as physical and chemical origins. These scenarios should involve further great amplification mechanisms, enabling a pure L- or D-world.
Author | : Thomas Klockgether |
Publisher | : CRC Press |
Total Pages | : 716 |
Release | : 2000-08-18 |
Genre | : Medical |
ISBN | : 9781420002065 |
This timely reference presents, for the first time, new findings in molecular genetics that are applicable to the epidemiology, pathogenesis, neuropathology, clinical features, and management of ataxia-bridging the gap between scientific and clinical practice. Organized by the distinctive ataxia disorders, their pathogenesis, and management-facilitating quick and efficient diagnoses! Providing complementary sections on the anatomy of the spinocerebellar system, its normal function, and a history of ataxia research and management, the Handbook of Ataxia Disorders clarifies the impact of identifying the molecular causes of ataxia offers in-depth analysis of dominant and recessive and nonhereditary ataxia disorders explores the vital connection between the genotypes and phenotypes of various degenerative ataxia disorders and more! Written by more than 60 international experts and supplemented with over 2600 literature references, photographs, micrographs, drawings, and tables, the Handbook of Ataxia Disorders is an essential and useful reference for clinical neurologists and neuropathologists, neuropediatricians, geneticists, physiatrists, and medical school students in these disciplines.
Author | : F.W. Van Leeuwen |
Publisher | : Elsevier |
Total Pages | : 551 |
Release | : 1998-11-09 |
Genre | : Psychology |
ISBN | : 008086242X |
This book is the result of the 20th International Summer School in Brain Research, organized in August 1997 in Amsterdam, by the Netherlands Institute for Brain Research at the Royal Netherlands Academy of Sciences. It is the first book that provides a complete overview of the field of neurodegeneration and regeneration including spinal cord injury, neurodegenerative diseases and therapy. Divided into five sections, the first two sections give an overview of fundamental research on nerve cell death, neuronal survival, neurite outgrowth and guidance. Extensive attention is given to the role of neurotrophins, their receptor tyrosine kinases and cell-adhesion molecules in development and regeneration of the nervous system. The third section of the book is devoted to research involving human neurodegenerative diseases and emerging treatment strategies. Section four focusses on recent advances in the understanding of pathophysiological mechanisms underlying neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases along with prion diseases. Novel insights into the neuropathological hallmarks of these diseases, as well as into transgenic animal models, the involvement of environmental factors, and genomic and mRNA changes that can cause neurodegeneration. The final section of this volume reveals recent developments in the use of cell and gene therapy to treat neurodegenerative disease and lesion-related deficits. Implantation of genetically modified cells, direct gene transfer with viral vectors and the first clinical trials with encapsulated genetically modified cells in patients suffering from amyotrophic lateral scelerosis are examples of new therapeutic strategies treating neurodegenerative diseases.The book is of particular interest to departments of neuroscience, neurological clinics and departments, the pharmalogical industry and medical libraries.
Author | : Ros Eng |
Publisher | : CRC Press |
Total Pages | : 468 |
Release | : 2004-08-27 |
Genre | : Medical |
ISBN | : 0340762543 |
Over the last 20 years it has become increasingly apparent that the occurrence of many cancers can have an inherited basis. This book examines the principles underlying genetic predisposition to cancer and will be relevant to practising oncologists, geneticists and other professionals interested in this rapidly expanding field. Coverage is comprehensive, taking the reader from an introduction to genetic predisposition, through a discussion of the molecular biology and statistical techniques involved in the identification and characterisation of predisposition genes, to a consideration of heritable cancer syndromes, and encompasses both rare and common cancers. The text also features a discussion of cancer risk assessment, genetic counselling issues, genetic screening and cancer management options, and a consideration of the associated ethical and psychological issues. Building on the reputation of the previous edition, and to reflect the rapid advances in the field since its publication, the contents of the second edition have been thoroughly updated and include discussion of many newly identified cancer genes. In particular, the book features new chapters added on the biological basis of cancer predisposition, population-based studies of susceptibility, and evaluation of management strategies for individuals at increased cancer risk.