Application of Toxicogenomics to Cross-Species Extrapolation

Application of Toxicogenomics to Cross-Species Extrapolation
Author: National Research Council
Publisher: National Academies Press
Total Pages: 58
Release: 2006-05-24
Genre: Science
ISBN: 0309100844

Some of what we know about the health effects of exposure to chemicals from food, drugs, and the environment come from studies of occupational, inadvertent, or accident-related exposures. When there is not enough human data, scientists rely on animal data to assess risk from chemical exposure and make health and safety decisions. However, humans and animals can respond differently to chemicals, including the types of adverse effects experienced and the dosages at which they occur. Scientists in the field of toxicogenomics are using new technologies to study the effects of chemicals. For example, in response to a particular chemical exposure, they can study gene expression ("transcriptomics"), proteins ("proteomics") and metabolites ("metabolomics"), and they can also look at how individual and species differences in the underlying DNA sequence itself can result in different responses to the environment. Based on a workshop held in August 2004, this report explores how toxicogenomics could enhance scientists' ability to make connections between data from experimental animal studies and human health.

Environmental Genomics

Environmental Genomics
Author: C. Cristofre Martin
Publisher: Springer Science & Business Media
Total Pages: 363
Release: 2008-01-18
Genre: Science
ISBN: 1588297772

Here is a manual for an environmental scientist who wishes to embrace genomics to answer environmental questions. The volume covers: gene expression profiling, whole genome and chromosome mutation detection, and methods to assay genome diversity and polymorphisms within a particular environment. This book provides a systematic framework for determining environmental impact and ensuring human health and the sustainability of natural populations.

Marine Ecotoxicology

Marine Ecotoxicology
Author: Julián Blasco
Publisher: Academic Press
Total Pages: 334
Release: 2016-08-05
Genre: Science
ISBN: 012803372X

Marine Ecotoxicology: Current Knowledge and Future Issues is the first unified resource to cover issues related to contamination, responses, and testing techniques of saltwater from a toxicological perspective. With its unprecedented focus on marine environments and logical chapter progression, this book is useful to graduate students, ecotoxicologists, risk assessors, and regulators involved or interested in marine waters. As human interaction with these environments increases, understanding of the pollutants and toxins introduced into the oceans becomes ever more critical, and this book builds a foundation of knowledge to assist scientists in studying, monitoring, and making decisions that affect both marine environments and human health. A team of world renowned experts provide detailed analyses of the most common contaminants in marine environments and explain the design and purpose of toxicity testing methods, while exploring the future of ecotoxicology studies in relation to the world's oceans. As the threat of increasing pollution in marine environments becomes an ever more tangible reality, Marine Ecotoxicology offers insights and guidance to mitigate that threat. - Provides practical tools and methods for assessing and monitoring the accumulation and effects of contaminants in marine environments - Unites world renowned experts in marine ecotoxicology to deliver thorough and diverse perspectives - Builds the foundation required for risk assessors and regulators to adequately assess and monitor the impact of pollution in marine environments - Offers helpful insights and guidance to graduate students, ecotoxicologists, risk assessors, and regulators interested in mitigating threats to marine waters

Fundamentals of Ecotoxicology

Fundamentals of Ecotoxicology
Author: Michael C. Newman
Publisher: CRC Press
Total Pages: 682
Release: 2019-11-27
Genre: Science
ISBN: 1351133985

This new edition is revised throughout and includes new and expanded information on natural resource damage assessment, the latest emerging contaminants and issues, and adds new international coverage, including case studies and rules and regulations. The text details key environmental contaminants, explores their fates in the biosphere, and discusses bioaccumulation and the effects of contaminants at increasing levels of ecological organization. Vignettes written by experts illustrate key themes or highlight especially pertinent examples. This edition offers an instructors' solution manual, PowerPoint slides, and supplemental images. Features: Adds all new discussions of natural resource damage assessment concepts and approaches Includes new vignettes written by leading guest authors Draws on materials from 2,500 cited sources, including 400+ new to this edition Adds numerous new entries to a useful glossary of 800+ terms Includes a new appendix discussing Brazilian environmental laws and regulations added to existing appendices outlining U.S., E.U., Chinese, Australian, and Indian environmental laws Fundamentals of Ecotoxicology: The Science of Pollution, Fifth Edition contains a broad overview of ecotoxicology and provides a basic understanding of the field. Designed as a textbook for use in introductory graduate or upper-level undergraduate courses in ecotoxicology, applied ecology, environmental pollution, and environmental science, it can also be used as a general reference for practicing environmental toxicologists.

Translational Toxicology

Translational Toxicology
Author: Claude L. Hughes
Publisher: Humana Press
Total Pages: 384
Release: 2016-03-23
Genre: Medical
ISBN: 331927449X

Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.

Mixture Toxicity

Mixture Toxicity
Author: Cornelis A. M. van Gestel
Publisher: CRC Press
Total Pages: 312
Release: 2016-04-19
Genre: Medical
ISBN: 1439830096

In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an

Genetic Toxicology

Genetic Toxicology
Author: James M. Parry
Publisher: Humana Press
Total Pages: 433
Release: 2011-12-07
Genre: Medical
ISBN: 9781617794209

The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types. In Genetic Toxicology: Principles and Methods, expert contributors help to satisfy the demand for education in this tremendously important area of study. The volume covers three basic areas: the scientific basis of the discipline, the methodologies of the main test assays, and the application of the methods, all aimed primarily at scientists in the safety departments of the industries working with both natural and synthetic chemicals. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Intuitive and cutting-edge, Genetic Toxicology: Principles and Methods provides crucial support to both laboratory workers in providing quality information on the appropriate application of techniques and to study directors in their assay selection and protocol design in this vital field.

Principles of Ecotoxicology, Second Edition

Principles of Ecotoxicology, Second Edition
Author: C.H. Walker
Publisher: CRC Press
Total Pages: 326
Release: 2003-09-02
Genre: Science
ISBN: 0203209575

Over the past decade ecotoxicology has emerged as a distinct subject of interdisciplinary character. Courses in ecotoxicology reflect this and are taught by specialists in chemistry and biochemistry through to population genetics and ecology. As the first textbook to incorporate all relevant aspects of chemistry, biochemistry, toxicology, physiology, population ecology and population genetics, the first edition of this book proved to be well received across several industries. Featuring fully revised text and new illustrations, Principles of Ecotoxicology identifies the major classes of organic and inorganic pollutants, their properties, release and environmental fate, and transport in air, water and along food chains, before considering the effects that they might have upon individual organisms and ultimately whole ecosystems. This timely second edition of Principles of Ecotoxicology incorporates data collected since the first edition on subjects of current research and media interest such as organochloride pesticides, endocrine disruptors, aquatic toxicity, industrial waste and ecotoxicity testing.

Genetic Algorithms in Molecular Modeling

Genetic Algorithms in Molecular Modeling
Author: James Devillers
Publisher: Academic Press
Total Pages: 345
Release: 1996-06-07
Genre: Science
ISBN: 0080532381

Genetic Algorithms in Molecular Modeling is the first book available on the use of genetic algorithms in molecular design. This volume marks the beginning of an ew series of books, Principles in Qsar and Drug Design, which will be an indispensible reference for students and professionals involved in medicinal chemistry, pharmacology, (eco)toxicology, and agrochemistry. Each comprehensive chapter is written by a distinguished researcher in the field. Through its up to the minute content, extensive bibliography, and essential information on software availability, this book leads the reader from the theoretical aspects to the practical applications. It enables the uninitiated reader to apply genetic algorithms for modeling the biological activities and properties of chemicals, and provides the trained scientist with the most up to date information on the topic. - Extremely topical and timely - Sets the foundations for the development of computer-aided tools for solving numerous problems in QSAR and drug design - Written to be accessible without prior direct experience in genetic algorithms