Genetic Analysis Of Herpesvirus Entry Receptors And Host Susceptibility To Herpes Simplex Virus Infection
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| Author | : Ann Arvin |
| Publisher | : Cambridge University Press |
| Total Pages | : 1325 |
| Release | : 2007-08-16 |
| Genre | : Medical |
| ISBN | : 1139461648 |
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
| Author | : Frank Struyf |
| Publisher | : Leuven University Press |
| Total Pages | : 142 |
| Release | : 2004-09 |
| Genre | : |
| ISBN | : 9789058674012 |
| Author | : Israel Vlodavsky |
| Publisher | : Springer Nature |
| Total Pages | : 871 |
| Release | : 2020-04-09 |
| Genre | : Medical |
| ISBN | : 3030345211 |
Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
| Author | : Klaus Osterrieder |
| Publisher | : Springer |
| Total Pages | : 226 |
| Release | : 2017-05-20 |
| Genre | : Medical |
| ISBN | : 3319531689 |
Herpes viruses are widely distributed in nature, causing disease in organisms as diverse as bivalves and primates, including humans. Each virus appears to have established a long-standing relationship with its host, and the viruses have the ability to manipulate and control the metabolism of host cells, as well as innate and adaptive antiviral immune responses. Herpes viruses maintain themselves within hosts in a latent state resulting in virus persistence for years – usually for the life span of the hosts. Herpes viruses comprise a large number of pathogens with diverse cellular targets and biological consequences of infection. What they have in common is their structure and the fact that they establish a dormant (latent) infection in their hosts that usually persists for life. The reviews here will highlight the general principles of herpes virus infection, with equal attention to overall principle and important difference. Also, the cell type- and life-style dependent differences in the establishment and maintenance of virus persistence will be covered.
| Author | : Nilesh Sharma |
| Publisher | : Springer Nature |
| Total Pages | : 462 |
| Release | : 2021-03-26 |
| Genre | : Science |
| ISBN | : 3030657922 |
The range of nanomaterial applications has expanded recently from catalysis, electronics, and filtration to therapeutics, diagnostics, agriculture, and food because of unique properties and potentials of different nanoparticles and nanomaterials. Research shows that these exquisite particles can interact with an organism at the cellular, physiological, biochemical, and molecular levels. However, our knowledge of how they affect these changes, selectively or generally, in diverse organism or ecosystems is very limited and far from satisfactory. Data indicate that the biological function largely depends on the shape, size, and surface characteristics of the nanoparticles used besides life cycle stages of an organism. Therefore, this compilation will focus on the body of work carried out by distinguished investigators using diverse nanomaterials and plant and animal species. This book includes specific case studies as well as general review articles highlighting aspects of multilayered interactions, and targets not only research and academic scholars but also the concerned industry and policy makers as well.
| Author | : Thomas E. Shenk |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 477 |
| Release | : 2008-05-09 |
| Genre | : Medical |
| ISBN | : 3540773495 |
This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.
| Author | : |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2002 |
| Genre | : Cells |
| ISBN | : 9780815332183 |
| Author | : M. A. Epstein |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 467 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642672361 |
The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.
| Author | : Urs F. Greber |
| Publisher | : Springer |
| Total Pages | : 235 |
| Release | : 2019-07-17 |
| Genre | : Medical |
| ISBN | : 303014741X |
This book explores a new challenge in virology: to understand how physical properties of virus particles (virions) and viruses (infected cells) affect the course of an infection. Insights from the emerging field of physical virology will contribute to understanding of the physical nature of viruses and cells, and will open new ways for anti-viral interference. Nine chapters and an editorial written by physicists, chemists, biologists and computational experts describe how virions serve as trail blazers in uncharted territory of cells. The authors outline how particles change in composition as they interact with host cells. Such virus dynamics are crucial for virus entry into cells and infection. It influences the modern concepts of virus-host interactions, viral lineages and evolution. The volume gives numerous up-to-date examples of modern virology and provides a fascinating read for researchers, clinicians and students in the field of infectious diseases.
| Author | : Adel Elkady |
| Publisher | : Cambridge University Press |
| Total Pages | : 215 |
| Release | : 2019-10-24 |
| Genre | : Medical |
| ISBN | : 1108716636 |
Provides effective diagnosis and management of infectious diseases in pregnant women in a single comprehensive available resource for busy clinicians.
