Fetal Cells and Fetal DNA in Maternal Blood

Fetal Cells and Fetal DNA in Maternal Blood
Author: Sinuhe Hahn
Publisher: Karger Medical and Scientific Publishers
Total Pages: 145
Release: 2001-01-01
Genre: Medical
ISBN: 3805572220

Is noninvasive, risk-free prenatal diagnosis of fetal genetic characteristics still a fantasy, or will it soon become reality? The current status of both the leading European research groups as well as the NIH-funded NIFTY study are reported here, indicating that certain fetal genetic traits can now be examined efficiently in a noninvasive manner. Considerable focus is placed on new laser-mediated systems for the effective micro-manipulation of single fetal cells, as well as their analysis by single-cell PCR and the pitfalls to avoid when performing such analyses. Other issues addressed in depth include: novel enrichment techniques, optimal fetal cell recognition, fetal cell culture, as well as the exciting finding that fetal cell traffic is elevated in certain pregnancy-related disorders, most prominently in preeclampsia. This publication is of interest to researchers in the field, genetic counsellors, gynecologists and obstetricians, and researchers in microchimerism, transplantation and transfusion medicine.

Prevention of Thalassaemias and Other Haemoglobin Disorders

Prevention of Thalassaemias and Other Haemoglobin Disorders
Author: Galanello Renzo
Publisher:
Total Pages: 190
Release: 2003
Genre:
ISBN: 9789963623396

Volume 1 of the Prevention Book presents the principles of a programme for the prevention of the thalassaemia and other haemoglobin disorders, including a description of the various types of disorders requiring prenatal diagnosis, the strategies used for carrier screening, and a number of annexes listing upto date epidemiological and mutation data on thalassaemia. This book was written for use in combination with Volume 2, which describes many of the laboratory protocols in great detail.

Perinatal Stem Cells

Perinatal Stem Cells
Author: Anthony Atala
Publisher: Academic Press
Total Pages: 438
Release: 2018-06-14
Genre: Medical
ISBN: 0128120630

Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells

Fetal Cells in Maternal Blood

Fetal Cells in Maternal Blood
Author: Joe Leigh Simpson
Publisher:
Total Pages: 296
Release: 1994
Genre: Health & Fitness
ISBN:

Several lines of evidence indicate that foetal cells - lymphocytes, nucleated red cells, trophoblasts - exist in maternal blood during pregnancy. The potential thus exists for recovering foetal cells from maternal blood and then analysing these cells for foetal genetic abnormalities. This volume explores the biology and maternal foetal transfer of the three cell types during pregnancy, the use of flow cytometry and other techniques to enrich the yield of these cells from maternal blood, the application of diagnostic techniques for identifying cytogenetic and other genetic abnormalities, and public health and other issues involved in the implementation of such testing.

Fetal Cells and Fetal DNA in Maternal Blood

Fetal Cells and Fetal DNA in Maternal Blood
Author: S. Hahn
Publisher:
Total Pages: 0
Release: 2001
Genre: Medical
ISBN: 9783318006995

Is noninvasive, risk-free prenatal diagnosis of fetal genetic characteristics still a fantasy, or will it soon become reality? The current status of both the leading European research groups as well as the NIH-funded NIFTY study are reported here, indicating that certain fetal genetic traits can now be examined efficiently in a noninvasive manner. Considerable focus is placed on new laser-mediated systems for the effective micro-manipulation of single fetal cells, as well as their analysis by single-cell PCR and the pitfalls to avoid when performing such analyses. Other issues addressed in depth include: novel enrichment techniques, optimal fetal cell recognition, fetal cell culture, as well as the exciting finding that fetal cell traffic is elevated in certain pregnancy-related disorders, most prominently in preeclampsia. This publication is of interest to researchers in the field, genetic counsellors, gynecologists and obstetricians, and researchers in microchimerism, transplantation and transfusion medicine.

Assessing Genetic Risks

Assessing Genetic Risks
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 353
Release: 1994-01-01
Genre: Medical
ISBN: 0309047986

Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.

Fetal Cells in Maternal Blood

Fetal Cells in Maternal Blood
Author: Joe Leigh Simpson
Publisher:
Total Pages: 296
Release: 1994
Genre: Health & Fitness
ISBN:

Several lines of evidence indicate that foetal cells - lymphocytes, nucleated red cells, trophoblasts - exist in maternal blood during pregnancy. The potential thus exists for recovering foetal cells from maternal blood and then analysing these cells for foetal genetic abnormalities. This volume explores the biology and maternal foetal transfer of the three cell types during pregnancy, the use of flow cytometry and other techniques to enrich the yield of these cells from maternal blood, the application of diagnostic techniques for identifying cytogenetic and other genetic abnormalities, and public health and other issues involved in the implementation of such testing.