Loss is a part of every life, and grief related to loss is inescapable. It can result in distress that impacts work, learning, rehabilitation, spiritual beliefs, social relationships, health, mental health, and well-being. Helping professionals who encounter grief reactions in multiple settings are often not trained to identify and respond to the many complex grief-related problems of clients. Without the opportunity to learn how to assess and address grief, many may lack confidence in acknowledging loss and providing effective support. Although grieving is an extremely painful part of life, integration and adjustment are possible, and meaning can be made from loss. Readers will find many examples from caring and resilient students, interdisciplinary professionals, teachers, clients, and family members who have learned to make meaning from loss. The content of the third edition has been significantly influenced by the COVID-19 pandemic, the opioid addiction crisis, and increased awareness of racial trauma and injustice. The book provides a foundation for understanding, assessing, and responding effectively to grief and loss. The content is designed for students and professionals who find themselves working in proximity to loss, trauma, and grief in various capacities—educator, advocate, case manager, counselor, mental health and health care provider, and more. The work is vitally important, and the rewards for helping others cope with grief and loss are substantial.