Gastric Cytoprotection Experimental And Clinical Studies
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Gastric Cytoprotection
| Author | : Daniel Hollander |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 228 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1468456970 |
Gastric secretions contain hydrogen ions at a concentration that is more than one million times higher than their intracellular concentration. This phenomenal gradient as well as the demonstrated ability of gastric juice to digest tissues has motivated clinicians and investigators alike to emphasize acid secretion and acid ablation in studying the pathogenesis and therapy of peptic ulcer disease. Conse quently, over the past 150 years, we have made considerable progress in under standing the mechanisms and regulation of acid secretion by the stomach. Not surprisingly, therapy for both peptic disease and mucosal injury has also been predominantly directed at either neutralizing acid or suppressing its production. During the past 10 years, attention has been focused on factors other than acid in the genesis and therapy of ulcer disease. Work done worldwide demon strated that acid hypersecretion is not a common event in peptic ulcer disease. Therefore, we began realizing that factors other than acid secretion may be important in the genesis of ulcer disease or in gastroduodenal mucosal damage. In addition, new physiological information has established that the gas troduodenal mucosa is normally protected by a complex series of events includ ing mucus and bicarbonate secretion, cell renewal, surface mucosal restitution, and preservation of the microvasculature and mucosal proliferative zone.
Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract
| Author | : L.P. Filaretova |
| Publisher | : Karger Medical and Scientific Publishers |
| Total Pages | : 259 |
| Release | : 2012-06-22 |
| Genre | : Medical |
| ISBN | : 3318021849 |
In recent years, there have been significant advances both in understanding the mechanisms involved in gastrointestinal mucosal injury and protection, as well as in the development of successful strategies for prevention and treatment of gastrointestinal injury. Nevertheless, many people worldwide still suffer from gastrointestinal damage.This book contains contributions by an international panel of researchers in the form of up-to-date reviews on the mechanisms of gastrointestinal injury and protection. These are complemented by papers discussing how these new findings about cell/tissue injury and cytoprotection/organoprotection can be applied to the prevention and treatment of tissue damage in the gastrointestinal tract. Moreover, the publication includes a special chapter on Andre Robert, who has discovered the phenomenon of gastric cytoprotection.This publication will be of great interest for both basic and clinical researchers in gastroenterology and pharmacology, reviewing the advances made so far and pointing towards future developments.
Membrane-bound Atp-dependent Energy Systems and the Gastrointestinal Mucosal Damage and Protection
| Author | : Gyula Mozsik |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 368 |
| Release | : 2016-03-09 |
| Genre | : Medical |
| ISBN | : 9535122517 |
The book on Membrane-bound Atp-dependent Energy Systems and the Gastrointestinal Mucosal Damage and Protection deals with various aspects of peptic ulcer disease, like clinical pharmacology, nutrition, molecular biochemical pharmacology as well as clinical aspects, and especially with the evaluation of certain biochemical mechanisms in human gastric mucosa and in animal gastric tissues obtained from different ulcer models. This book can be useful to physiologists; biochemists; pharmacologists, particularly molecular and biochemical pharmacologists; internists; gastroenterologists; biologists; surgeons and pharmacists.
Cell Injury and Protection in the Gastrointestinal Tract
| Author | : Gyula Mózsik |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 366 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 9401153922 |
The scientific main programmes of these series of symposia changed from time to time following the international scientific trends. The main programmes of the First Symposium were: 1. Gastric and intestinal cytoprotection; 2. Hepatoprotection; 3. Pancreatic protection. For the second one: 1. Gastrointestinal mucosal 'cytoprotection'; 2. Liver 'cytoprotection'; 3. Pancreatic 'cytoprotection'; 4. Free radicals and scavangers; 5. Computer approach to cytoprotec tion. For the third one: 1. Basic, central, peripheral and cellular mechanisms of gastrointestinaol cytoprotection; 2. Esophagal protection; 3. Gastric protection; 4. Small intestinal injury and protection; 5. Large bowel injury and protection; 6. Liver injury and protection; 7. Pancreas injury and protection. The main scientific programmes of the Fourth International Symposium on 'Cell Injury and Protection in the Gastrointestinal Tract' are: 1. General mechanisms of gastrointestinal injury and protection; 2. Cell injury and protection in the stomach; 3. Cell injury and protection in the small intestine and in the large bowel; 4. Cell injury and protection in the liver and pancreas; 5. Cell injury and protection of the premalignant status and malignant diseases in the gastrointestinal tract. The presented papers are published in this book. The abstracts of this meeting were published in Digestive Diseases and Sciences, and we record appreciation of the Editor ofthatjoumal for their publication. Some of the papers published here have appeared in Inflammopharmacology 1996;4:331-398.
Ulcer Disease
| Author | : Sandor Szabo |
| Publisher | : CRC Press |
| Total Pages | : 494 |
| Release | : 1989-07-31 |
| Genre | : Medical |
| ISBN | : 9780849362163 |
The latest data on the pathogenesis of ulcer disease is presented in this text, with the emphasis that an understanding of the pathogenesis and etiology of ulcer diseases represents the most rational approach to pharmacology - the prevention and treatment of ulcer disease. Early and late biochemical and functional changes, morphologic stages of the injury and healing phases, as well as vascular factors in ulceration are highlighted. In addition, new pathogenetic elements on neuroendocrine and other endogenous modulators and circadian rhythms in ulcerogenesis are covered. The section on new pharmacology consists of several chapters presenting new animal models of gastric, small intestinal and colonic ulcers because in vivo models represent the basis to test and accurately detect new antiulcer drugs. A large series of chapters cover new drugs for ulcer prevention and treatment. This book is indispensible to investigators in basic and applied research, academic and industrial pharmacologists and clinicians in gastroenterology.
Neuroendocrinology of Gastrointestinal Ulceration
| Author | : Sandor Szabo |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 251 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1461518679 |
Proceedings of a meeting held in Esterel, Quebec, Canada, September 13-15, 1989.
