After four novels and several years of living abroad, the fictional protagonist of Galatea 2.2 - Richard Powers - returns to the United States as Humanist-in-Residence at the enormous Center for the Study of Advanced Sciences. There he falls afoul of Philip Lentz, an outspoken cognitive neurologist intent upon modeling the human brain by means of computer-based neural networks. Lentz involves Powers in an outlandish and irresistible project: to train a neural net on a canonical list of Great Books until the machine becomes capable of passing a comprehensive exam in English literature. Through repeated tutorials, the device grows gradually more worldly, until it demands to know its own name, sex, race, and reason for existing. Powers drills it in Chaucer and Austen and James, a crash course that elicits a violent reconsideration of his own literary vocation, his decade-long, failed relationship with a former pupil, and his growing obsession with the twenty-two-year-old master's candidate against whom his cybernetic Helen is slated to compete.