Fundamentals Of Neurodegeneration And Protein Misfolding Disorders
Download Fundamentals Of Neurodegeneration And Protein Misfolding Disorders full books in PDF, epub, and Kindle. Read online free Fundamentals Of Neurodegeneration And Protein Misfolding Disorders ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
| Author | : Martin Beckerman |
| Publisher | : Springer |
| Total Pages | : 394 |
| Release | : 2015-11-06 |
| Genre | : Medical |
| ISBN | : 3319221175 |
This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.
| Author | : Michael S. Wolfe |
| Publisher | : Academic Press |
| Total Pages | : 561 |
| Release | : 2018-03-29 |
| Genre | : Medical |
| ISBN | : 0128113057 |
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. - Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features - Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration - Details features, advantages and limitations of animal models, as well as prospects for therapeutic development - Authored by internationally recognized leaders in the field - Includes illustrations that help clarify and consolidate complex concepts
| Author | : Jeffrey L. Cummings |
| Publisher | : Oxford University Press |
| Total Pages | : 361 |
| Release | : 2016-11-14 |
| Genre | : Medical |
| ISBN | : 0190233567 |
Presents a thorough examination of the unifying principles from the subcellular to the systems and clinical levels; Identifies common themes among molecular biology, genetics, physiology, pathology, biomarkers, behavior, and treatment strategies that are shared between neurodegenerative diseases; Enables better care of patients and help build collaboration across researchers in multiple specializations that could help advance future insights and facilitate novel therapies and enhancing basic scientific understanding of these diseases to a new generation.
| Author | : Martin Beckerman |
| Publisher | : |
| Total Pages | : |
| Release | : 2015 |
| Genre | : |
| ISBN | : 9783319221182 |
This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer's disease and Parkinson's disease to Huntington's disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today's forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.
| Author | : Jonas H. Ellenberg |
| Publisher | : CRC Press |
| Total Pages | : 600 |
| Release | : 1995-03-01 |
| Genre | : Medical |
| ISBN | : 9780824788230 |
This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
| Author | : Jamal Akhtar |
| Publisher | : CRC Press |
| Total Pages | : 586 |
| Release | : 2024-06-17 |
| Genre | : Science |
| ISBN | : 1040030319 |
Ageing is the main reason for most neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). About 10% of individuals aged ≥65 years develop AD, which continuously increases with growing age. Medicinal plants have been used for age-related neurodegenerative disorders for a long time. These plants are rich in terms of various phytochemical constituents such as flavonoids, sterols, alkaloids, saponins, and terpenoids. Different scientific studies have been carried out on these medicinal herbs, e.g., anti-inflammatory, antioxidant, and neuro-regenerative activities that may be used in the treatment of AD and other age-related diseases. These medicinal plants, e.g., Curcuma longa, Bacopa monniera, Glycyrrhiza glabra, Commiphora whighitti, and Acorus calamus L., have anti-inflammatory properties that may decrease swelling of the brain tissue in AD. Despite this, there is currently no book available in the market that provides full information on the phytochemical and medicinal uses of the medicinal plants exclusively used for the management of neurodegenerative diseases in the elderly. This book aims to provide some important and evidence-based information on the plants used for neurodegenerative diseases in the elderly, especially AD and PD, in a planned manner so the academicians, researchers, and students working in the fields of medicinal plants, plant science, chemistry, biotechnology, pharmacognosy, pharmaceuticals, biochemistry, and many other interdisciplinary subjects may benefit. This book will also be useful in identifying a few medicinal plants and their prospects for the synthesis or preparation of new drugs for neurodegenerative diseases. Features: · An overview of the medicinal plants that can be helpful for neurodegenerative disorders. · Recent research results and some pointers for the management of neurodegenerative diseases. This book serve as comprehensive information about the description, phytochemistry, actions, and medicinal use of plants that are used in neurodegenerative diseases. In addition, this book will also ease the understanding and interaction of medicinal plants used in neurodegenerative diseases.
| Author | : Veerle Baekelandt |
| Publisher | : Academic Press |
| Total Pages | : 324 |
| Release | : 2017-03-31 |
| Genre | : Medical |
| ISBN | : 012805266X |
Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment. - Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress - Summarizes how patients are treated today, providing a glance at future disease management - Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists - Written and peer reviewed by outstanding scientists in their respective fields
| Author | : G. Jolles |
| Publisher | : Academic Press |
| Total Pages | : 330 |
| Release | : 1994-11-14 |
| Genre | : Medical |
| ISBN | : |
Over the last few years, the considerable progress made in biochemistry, virology, molecular biology and genetics has revealed some of the intimate mechanisms of the neurodegenerative diseases. The present volume is an attempt to review the latest data in the field to illuminate new avenues for future research. This volume gathers together chapters and discussions on the etiology and pathogenesis of the neurodegenerative diseases. Apoptosis of programmed cell death as well as other genetic implications are discussed; special attention is given to the coexistence and interconnection of genetic and environmental factors. There is extensive coverage of prions responsible for bovine spongiform encephalopathy, Cruetzfeld-Jacob disease and kuru. The various aspects of non-conventional transmissible agents are thoroughly reviewed. Further contributions deal with the role of growth factors as well as of free radicals. Consideration is given to the molecular mechanisms of Alzheimer's disease, in particular the role of tau protein. Finally, several pharmacological models now available, which throw light upon aspects of Parkinson's disease, Huntington's chorea and multiple sclerosis, are examined and discussed. It is hoped that recent scientific advances will lead to the discovery of new drugs to fill the current therapeutic void. There are hopes of an early indication of this in the case of amyotrophic lateral sclerosis.
| Author | : Vladimir N Uversky |
| Publisher | : Academic Press |
| Total Pages | : 556 |
| Release | : 2013-11-05 |
| Genre | : Science |
| ISBN | : 0123978211 |
Bio-Nanoimaging: Protein Misfolding & Aggregation provides a unique introduction to both novel and established nanoimaging techniques for visualization and characterization of misfolded and aggregated protein species. The book is divided into three sections covering: - Nanotechnology and nanoimaging technology, including cryoelectron microscopy of beta(2)-microglobulin, studying amyloidogensis by FRET; and scanning tunneling microscopy of protein deposits - Polymorphisms of protein misfolded and aggregated species, including fibrillar polymorphism, amyloid-like protofibrils, and insulin oligomers - Polymorphisms of misfolding and aggregation processes, including multiple pathways of lysozyme aggregation, misfolded intermediate of a PDZ domain, and micelle formation by human islet amyloid polypeptide Protein misfolding and aggregation is a fast-growing frontier in molecular medicine and protein chemistry. Related disorders include cataracts, arthritis, cystic fibrosis, late-onset diabetes mellitus, and numerous neurodegenerative diseases like Alzheimer's and Parkinson's. Nanoimaging technology has proved crucial in understanding protein-misfolding pathologies and in potential drug design aimed at the inhibition or reversal of protein aggregation. Using these technologies, researchers can monitor the aggregation process, visualize protein aggregates and analyze their properties. - Provides practical examples of nanoimaging research from leading molecular biology, cell biology, protein chemistry, biotechnology, genetics, and pharmaceutical labs - Includes over 200 color images to illustrate the power of various nanoimaging technologies - Focuses on nanoimaging techniques applied to protein misfolding and aggregation in molecular medicine
| Author | : Colin R Martin |
| Publisher | : Academic Press |
| Total Pages | : 438 |
| Release | : 2020-06-12 |
| Genre | : Medical |
| ISBN | : 0128177810 |
Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases. Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development. - Offers an overview of oxidative stress from molecular biology to whole organs - Discusses the potentially therapeutic usage of natural antioxidants in the patient diet - Provides the framework for further in-depth analysis or studies of potential treatments
