Fundamentals Of Experimental Pharmacology
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Fundamentals of Experimental Pharmacology
| Author | : Torald Hermann Sollmann |
| Publisher | : |
| Total Pages | : 312 |
| Release | : 1939 |
| Genre | : Drugs |
| ISBN | : |
Practical Manual of Experimental and Clinical Pharmacology
| Author | : Bikash Mehdi |
| Publisher | : Jaypee Brothers,Medical Publishers Pvt. Limited |
| Total Pages | : 430 |
| Release | : 2016-10-26 |
| Genre | : Medical |
| ISBN | : 9789386150721 |
Concepts and Principles of Pharmacology
| Author | : James E. Barrett |
| Publisher | : Springer Nature |
| Total Pages | : 466 |
| Release | : 2019-12-24 |
| Genre | : Medical |
| ISBN | : 3030353621 |
Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.
Drug Delivery
| Author | : Monika Schäfer-Korting |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 506 |
| Release | : 2010-03-10 |
| Genre | : Medical |
| ISBN | : 3642004776 |
In the view of most experts pharmacology is on drugs, targets, and actions. In the context the drug as a rule is seen as an active pharmaceutical ingredient and not as a complex mixture of chemical entities of a well defined structure. Today, we are becoming more and more aware of the fact that delivery of the active compound to the target site is a key. The present volume gives a topical overview on various modern approaches to drug targeting covering today’s options for specific carrier systems allowing successful drug treatment at various sites of the body difficult to address and allowing to increase the benefit-risk-ratio to the optimum possible.
Antibody-Drug Conjugates
| Author | : Kenneth J. Olivier, Jr. |
| Publisher | : John Wiley & Sons |
| Total Pages | : 567 |
| Release | : 2016-11-14 |
| Genre | : Medical |
| ISBN | : 1119060842 |
Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development
General and Molecular Pharmacology
| Author | : Francesco Clementi |
| Publisher | : John Wiley & Sons |
| Total Pages | : 784 |
| Release | : 2015-07-01 |
| Genre | : Medical |
| ISBN | : 1118768590 |
With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book
Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics
| Author | : Alexander A. Vinks |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 467 |
| Release | : 2013-11-23 |
| Genre | : Medical |
| ISBN | : 0387756132 |
Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.
Metabolomics: From Fundamentals to Clinical Applications
| Author | : Alessandra Sussulini |
| Publisher | : Springer |
| Total Pages | : 353 |
| Release | : 2017-01-28 |
| Genre | : Science |
| ISBN | : 3319476564 |
This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.
Novel Psychoactive Substances
| Author | : Paul I. Dargan |
| Publisher | : Academic Press |
| Total Pages | : 438 |
| Release | : 2013-08-06 |
| Genre | : Medical |
| ISBN | : 0124159117 |
Novel Psychoactive Substances: Classification, Pharmacology and Toxicology provides readers with background on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." This book also covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance followed by a discussion of the acute and chronic harm or toxicity associated with the substance. Written by international experts in the field, this multi-authored book is a valuable reference for scientists, clinicians, academics, and regulatory and law enforcement professionals. - Includes chapters written by international experts in the field. - Provides a comprehensive look at the classification, detection, availability and supply of novel psychoactive substances, in addition to the pharmacology and toxicology associated with the substance. - Offers a single source for all interested parties working in this area, including scientists, academics, clinicians, law enforcement and regulatory agencies. - Provides a full treatment of novel psychoactive substances that have recently emerged onto the recreational drug scene including mephedrone and the synthetic cannabinoid receptors in 'spice' / 'K2'.
