From Basic Research To New Tools And Challenges For The Genotoxicity Testing Of Nanomaterials
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| Author | : Valérie Fessard |
| Publisher | : MDPI |
| Total Pages | : 188 |
| Release | : 2021-03-24 |
| Genre | : Medical |
| ISBN | : 3036501126 |
This Special Issue presents studies on the genotoxicity of nanomaterials. Although nanomaterials provide multiple benefits in a wide range of applications, challenges remain in addressing strong concerns about their risks to the environment and human health. As a result of inconsistencies among published results and diverging conclusions, the understanding of nanomaterial exposure and toxicity remains unclear. Determining whether these materials cause DNA damage—the first step in carcinogenesis—must be a priority in testing. In this book, readers will find recent publications on the genotoxic response to a broad range of nanomaterials, the impact of physico-chemical characteristics, safe-by-design and new developed tools.
| Author | : Valérie FESSARD |
| Publisher | : |
| Total Pages | : 188 |
| Release | : 2021 |
| Genre | : |
| ISBN | : 9783036501130 |
This Special Issue presents studies on the genotoxicity of nanomaterials. Although nanomaterials provide multiple benefits in a wide range of applications, challenges remain in addressing strong concerns about their risks to the environment and human health. As a result of inconsistencies among published results and diverging conclusions, the understanding of nanomaterial exposure and toxicity remains unclear. Determining whether these materials cause DNA damage--the first step in carcinogenesis--must be a priority in testing. In this book, readers will find recent publications on the genotoxic response to a broad range of nanomaterials, the impact of physico-chemical characteristics, safe-by-design and new developed tools.
| Author | : Ashis K. Basu |
| Publisher | : MDPI |
| Total Pages | : 275 |
| Release | : 2018-08-27 |
| Genre | : Science |
| ISBN | : 3038971294 |
This book is a printed edition of the Special Issue " Chemically-Induced DNA Damage, Mutagenesis, and Cancer" that was published in IJMS
| Author | : Alok Dhawan |
| Publisher | : Humana Press |
| Total Pages | : 0 |
| Release | : 2013-07-30 |
| Genre | : Medical |
| ISBN | : 9781627035286 |
Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals. In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetic toxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.
| Author | : Baoshan Xing |
| Publisher | : John Wiley & Sons |
| Total Pages | : 510 |
| Release | : 2016-08-29 |
| Genre | : Science |
| ISBN | : 1119275830 |
Details the source, release, exposure, adsorption, aggregation, bioavailability, transport, transformation, and modeling of engineered nanoparticles found in many common products and applications Covers synthesis, environmental application, detection, and characterization of engineered nanoparticles Details the toxicity and risk assessment of engineered nanoparticles Includes topics on the transport, transformation, and modeling of engineered nanoparticles Presents the latest developments and knowledge of engineered nanoparticles Written by world leading experts from prestigious universities and companies
| Author | : James Njuguna |
| Publisher | : Elsevier |
| Total Pages | : 345 |
| Release | : 2014-02-15 |
| Genre | : Technology & Engineering |
| ISBN | : 0857096672 |
Health and Environmental Safety of Nanomaterials addresses concerns about the impact of nanomaterials on the environment and human health, and examines the safety of specific nanomaterials. Understanding the unique chemical and physical properties of nanostructures has led to many developments in the applications of nanocomposite materials. While these materials have applications in a huge range of areas, their potential for toxicity must be thoroughly understood. Part one introduces the properties of nanomaterials, nanofillers, and nanocomposites, and questions whether they are more toxic than their bulk counterparts. Part two looks at the release and exposure of nanomaterials. The text covers sampling techniques and data analysis methods used to assess nanoparticle exposure, as well as protocols for testing the safety of polymer nanocomposites. It explains characterization techniques of airborne nanoparticles and life cycle assessment of engineered nanomaterials. Part three focuses on the safety of certain nanomaterials, including nanolayered silicates, carbon nanotubes, and metal oxides. In particular, it explores the potential ecotoxicological hazards associated with the different structures of carbon nanotubes and the safe recycling of inorganic and carbon nanoparticles. The final two chapters address the risks of nanomaterials in fire conditions: their thermal degradation, flammability, and toxicity in different fire scenarios. This is a scientific guide with technical background for professionals using nanomaterials in industry, scientists, academicians, research scholars, and polymer engineers. It also offers a deep understanding of the subject for undergraduate and postgraduate students. - Introduces the properties of nanomaterials, nanofillers, and nanocomposites, and questions whether they are more toxic than their bulk counterparts - Covers sampling techniques and data analysis methods used to assess nanoparticle exposure, as well as protocols for testing the safety of polymer nanocomposites - Explores the potential ecotoxicological hazards associated with the different structures of carbon nanotubes and the safe recycling of inorganic and carbon nanoparticles
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 23 |
| Release | : 2010-07-23 |
| Genre | : |
| ISBN | : 9264091017 |
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells. Micronuclei may originate from acentric chromosome fragments (i.e. lacking a centromere), or whole chromosomes that are ...
| Author | : Chaudhery Mustansar Hussain |
| Publisher | : John Wiley & Sons |
| Total Pages | : 597 |
| Release | : 2020-03-31 |
| Genre | : Technology & Engineering |
| ISBN | : 1119592968 |
This Handbook focuses on the recent advancements in Safety, Risk, Ethical Society and Legal Implications (ESLI) as well as its commercialization of nanotechnology, such as manufacturing. Nano is moving out of its relaxation phase of scientific route, and as new products go to market, organizations all over the world, as well as the general public, are discussing the environmental and health issues associated with nanotechnology. Nongovernmental science organizations have long since reacted; however, now the social sciences have begun to study the cultural portent of nanotechnology. Societal concerns and their newly constructed concepts, show nanoscience interconnected with the economy, ecology, health, and governance. This handbook addresses these new challenges and is divided into 7 sections: Nanomaterials and the Environment; Life Cycle Environmental Implications of Nanomanufacturing; Bioavailability and Toxicity of Manufactured Nanoparticles in Terrestrial Environments; Occupational Health Hazards of Nanoparticles; Ethical Issues in Nanotechnology; Commercialization of Nanotechnology; Legalization of Nanotechnology.
| Author | : Giada Frenzilli |
| Publisher | : MDPI |
| Total Pages | : 340 |
| Release | : 2021-05-26 |
| Genre | : Science |
| ISBN | : 3036507183 |
Do you care about your environment and your health? Contamination by hazardous substances in environmental matrices, including landfills, oil fields, and manufacturing and industrial sites, represents a global concern and needs to be remediated since it poses a serious risk to the environment and human health. Particular attention should also be paid to the use of medical devices and recent developments in the use of nanoparticles expressed as drug delivery systems designed to treat a wide variety of diseases. This Special Issue collects a compilation of articles that strongly demonstrate the continuous efforts made in developing advanced and safe nanomaterial-based technologies for nano-remediation and for drug delivery and other biomedical applications. It covers the most recent advances in the safe nanomaterials synthesis field as well as in environmental applications, in the use of restorative materials, drug delivery and other clinical applications, in order to lay the foundations for a cleaner and healthier future.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 217 |
| Release | : 2007-10-05 |
| Genre | : Nature |
| ISBN | : 0309109922 |
Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.
