Freeze-Drying/Lyophilization Of Pharmaceutical & Biological Products, Revised and Expanded

Freeze-Drying/Lyophilization Of Pharmaceutical & Biological Products, Revised and Expanded
Author: Louis Rey
Publisher: CRC Press
Total Pages: 634
Release: 2004-01-21
Genre: Medical
ISBN: 0203021320

Thoroughly acquainting the reader with freeze-drying fundamentals, Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products, Second Edition carves practical guidelines from the very latest theoretical research, technologies, and industrial procedures. It delineates the best execution of steps from closure preparation and regulatory control of products to equipment sterilization and process validation. With 13 new chapters providing state-of-the-art information, the book unveils innovations currently advancing the field, including LYOGUARD® packaging for bulk freeze-drying and the irradiation of pharmaceutical and biological products.

Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products

Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products
Author: Louis Rey
Publisher: CRC Press
Total Pages: 580
Release: 2016-04-19
Genre: Medical
ISBN: 1439825769

Freeze-drying, or lyophilization, is a well established technology used in the preservation of numerous pharmaceutical and biological products. This highly effective dehydration method involves the removal of water from frozen materials via the direct sublimation of ice. In recent years, this process has met with many changes, as have the regulatio

Advanced Drug Formulation Design to Optimize Therapeutic Outcomes

Advanced Drug Formulation Design to Optimize Therapeutic Outcomes
Author: Robert O. Williams
Publisher: CRC Press
Total Pages: 532
Release: 2007-09-25
Genre: Medical
ISBN: 1420043889

This title demonstrates how advanced formulation designs and delivery technologies can be used to improve drug efficacy and treatment outcomes in particular therapeutic categories or disease states. It discusses nanoparticle systems for cancer treatments, and also presents cutting edge immono-regulation agents for transplantation and the local targ

Transdermal Drug Delivery Systems

Transdermal Drug Delivery Systems
Author: Jonathan Hadgraft
Publisher: CRC Press
Total Pages: 296
Release: 2002-10-29
Genre: Medical
ISBN: 1135565198

Presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin; from physical chemistry and assessment of drug permeability to available enhancement technolgies, to regulator

Pharmaceutical Product Development

Pharmaceutical Product Development
Author: Chilukuri Dakshina Murthy
Publisher: CRC Press
Total Pages: 228
Release: 2007-02-12
Genre: Medical
ISBN: 100061154X

During the last two decades, the pharmaceutical industry has been under pressure to reduce development costs and the time needed to bring drugs to market in order to maximize return on investment and bring treatments to patients sooner. To meet these ends, pharmaceutical scientists working in the differing areas of pharmacy, pharmaceutics, and phar

Handbook of Pharmaceutical Analysis

Handbook of Pharmaceutical Analysis
Author: Lena Ohannesian
Publisher: CRC Press
Total Pages: 605
Release: 2001-11-09
Genre: Medical
ISBN: 0824741943

Exploring the analysis of pharmaceuticals, including polymorphic forms, this book discusses regulatory requirements in pharmaceutical product development and pharmaceutical testing. It covers methods of drug separation and procedures such as capillary electrophoresis for chromatographic separation of molecules. Additional topics include drug formulation analysis using vibrational and magnetic resonance spectroscopy and identification of drug metabolites and decomposition products using such techniques as mass spectrometry. The book provides more than 300 tables, equations, drawings, and photographs, and convenient, easy-to-use indices, facilitating quick access to each topic.

Transport Processes in Pharmaceutical Systems

Transport Processes in Pharmaceutical Systems
Author: Gordon L. Amidon
Publisher: CRC Press
Total Pages: 746
Release: 1999-11-24
Genre: Science
ISBN: 0824746325

This cutting-edge reference clearly explains pharmaceutical transport phenomena, demonstrating applications ranging from drug or nutrient uptake into vesicle or cell suspensions, drug dissolution and absorption across biological membranes, whole body kinetics, and drug release from polymer reservoirs and matrices to heat and mass transport in freeze-drying and hygroscopicity. Focuses on practical applications of drug delivery from a physical and mechanistic perspective, highlighting biological systems. Written by more than 30 international authorities in the field, Transport Processes in Pharmaceutical Systems discusses the crucial relationship between the transport process and thermodynamic factors analyzes the dynamics of diffusion at liquid-liquid, liquid-solid, and liquid-cultured cell interfaces covers prodrug design for improving membrane transport addresses the effects of external stimuli in altering some natural and synthetic polymer matrices examines properties of hydrogels, including synthesis, swelling degree, swelling kinetics, permeability, biocompatibility, and biodegradability presents mass transfer of drugs and pharmacokinetics based on mass balance descriptions and more! Containing over 1000 references and more than 1100 equations, drawings, photographs, micrographs, and tables, Transport Processes in Pharmaceutical Systems is a must-read resource for research pharmacists, pharmaceutical scientists and chemists, chemical engineers, physical chemists, and upper-level undergraduate and graduate students in these disciplines.

Pharmaceutical Photostability and Stabilization Technology

Pharmaceutical Photostability and Stabilization Technology
Author: Joseph T. Piechocki
Publisher: CRC Press
Total Pages: 445
Release: 2006-09-18
Genre: Medical
ISBN: 1420014137

Based on a training course developed by Dr. Joseph T. Piechocki and other experts in this field whose contributions appear in this book for two International Meetings on the Photostability of Drugs and Drug Products, this text clarifies the guidelines set by the International Conference on Harmonization (ICH) and provides a comprehensive background

Handbook of Drug Screening

Handbook of Drug Screening
Author: Ramakrishna Seethala
Publisher: CRC Press
Total Pages: 619
Release: 2001-07-24
Genre: Medical
ISBN: 0824741447

A presentation of screening techniques, modern technologies, and high-capacity instrumentation for increased productivity in the development and discovery of new drugs, chemical compounds, and targeted delivery of pharmaceuticals. It contains practical applications and examples of strategies in cell-based and cell-free screens as well as homogeneous, fluorescence, chemiluminescence, and radioactive-based technologies.

Biomarkers in Clinical Drug Development

Biomarkers in Clinical Drug Development
Author: John Bloom
Publisher: CRC Press
Total Pages: 312
Release: 2003-05-20
Genre: Medical
ISBN: 0824755197

Presenting applications in clinical development, pharmacokinetic/ pharmacodynamic modelling and clinical trial simulation, this reference studies the role of biomarkers in successful drug formulation and development.