Fragile Sites On Human Chromosomes
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Author | : Grant R. Sutherland |
Publisher | : |
Total Pages | : 312 |
Release | : 1985 |
Genre | : Science |
ISBN | : |
Fragile sites--points where chromosomes are apt to break--came to prominence in the late 1970s and are now the subject of much clinical concern and laboratory investigation. They are known or suspected agents in the genesis of mental retardation, birth defects, and cancer. This book, the first to deal with fragile sites on human chromosomes, takes a broad interdisciplinary approach to the subject, incorporating findings from cytogenetics, medical and clinical genetics, population genetics, mental retardation, dysmorphology, and oncology. The book has three interrelated sections. The first, focusing on the laboratory, presents what is known about fragile sites, their cytogenetics, and the conditions of cell culture needed to demonstrate them. A clinical section follows, covering X-linked forms of mental retardation, the clinical features associated with the fragile X, and genetic counseling with fragile sites. The final section considers fragile sites as they relate to genetics, including the possible relationship of fragile sites to cancer and to constitutional chromosome abnormalities. This book contains much previously unpublished material and will be an important resource for geneticists and cytogeneticists, molecular and cancer biologists, oncologists, pediatricians, and other health professionals.
Author | : Dominicus Franciscus Clemens Maria Smeets |
Publisher | : |
Total Pages | : 171 |
Release | : 1992 |
Genre | : |
ISBN | : |
Author | : Manfred Schwab |
Publisher | : Springer Science & Business Media |
Total Pages | : 1017 |
Release | : 2001-10-15 |
Genre | : Medical |
ISBN | : 3540665277 |
This comprehensive encyclopedic reference provides rapid and focused information about topics of cancer research for the clinical and basic scientist, students and informed laymen. It will be readily accessible, both electronically and in print, such that it will be of value to both the scientific community and the public.
Author | : Isabel Arrieta |
Publisher | : Nova Science Pub Incorporated |
Total Pages | : 359 |
Release | : 2006-11-06 |
Genre | : Science |
ISBN | : 9781600215049 |
Fragile sites common features of human (and also of other mammalian) chromosomes. Chromosomal fragile sites are non-randomly distributed loci that are especially prone to forming gaps, breaks or tri-radial figures in metaphase chromosomes when cells are cultured under conditions that inhibit DNA replication or repair. This new and important book is divided into 3 parts: 1. An overview about fragile sites on chromosomes, their classification, cytogenetics, expression, replication timing, and clinical significance and heritance, 2. The characteristics of fragile loci which lead to the expression of fragility specifically at these sites and 3. the link between fragile sites and human pathological conditions.
Author | : Julie Nancarrow |
Publisher | : |
Total Pages | : 462 |
Release | : 1998 |
Genre | : |
ISBN | : |
Author | : Orlando J. Miller |
Publisher | : Springer Science & Business Media |
Total Pages | : 508 |
Release | : 2011-06-28 |
Genre | : Medical |
ISBN | : 1461301394 |
The fourth edition of this well-known text provides students, researchers and technicians in the area of medicine, genetics and cell biology with a concise, understandable introduction to the structure and behavior of human chromosomes. This new edition continues to cover both basic and up-to-date material on normal and defective chromosomes, yet is particularly strengthened by the complete revision of the material on the molecular genetics of chromosomes and chromosomal defects. The mapping and molecular analysis of chromosomes is one of the most exciting and active areas of modern biomedical research, and this book will be invaluable to scientists, students, technicians and physicians with an interest in the function and dysfunction of chromosomes.
Author | : Aurora Ruiz-Herrera Moreno |
Publisher | : |
Total Pages | : 12 |
Release | : 2002 |
Genre | : |
ISBN | : |
Author | : Antonio Fratini |
Publisher | : |
Total Pages | : 304 |
Release | : 1988 |
Genre | : Linkage (Genetics) |
ISBN | : |
Author | : |
Publisher | : |
Total Pages | : 0 |
Release | : |
Genre | : |
ISBN | : |
Author | : Marco Muzi-Falconi |
Publisher | : Humana Press |
Total Pages | : 663 |
Release | : 2017-10-20 |
Genre | : Medical |
ISBN | : 9781493973057 |
This volume presents forty-two methods and protocols to analyze diverse aspects of genome instability. Chapters detail mutagenesis and repair, methods to quantify and analyze the properties of DNA double-strand breaks, profile replication, replication proteins strand-specifically, genome instability, fluorescence microscopic techniques, and genomic and proteomic approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genome Instability: Methods and Protocols aims to provide a comprehensive resource for the discovery and analysis of the proteins and pathways that are critical for stable maintenance of the genome.