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| Author | : Christophe Boete |
| Publisher | : CRC Press |
| Total Pages | : 198 |
| Release | : 2006-07-15 |
| Genre | : Medical |
| ISBN | : |
This book describes the epidemiological and evolutionary consequences of the use of genetically modified (GM) mosquitoes as well as research orientations and ethical issues concerning the use of GM mosquitoes. It also includes discussion on transgenic mosquitoes for malaria control.
| Author | : |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 258 |
| Release | : 2023-04-05 |
| Genre | : Medical |
| ISBN | : 1803567910 |
Malaria remains a leading cause of morbidity and mortality worldwide. Children in Africa and selected regions of Asia and Southern America are especially widely affected. Written by expert research teams, this book describes different aspects of the epidemiology, pathobiology, diagnosis, prevention, and treatment of malaria. Chapters highlight current research as well as the gold standards for diagnosis and treatment of the disease, examining recent advances, remaining pitfalls, and novel ideas about prophylaxis and therapy.
| Author | : Zach N. Adelman |
| Publisher | : Academic Press |
| Total Pages | : 487 |
| Release | : 2015-10-15 |
| Genre | : Medical |
| ISBN | : 0128004053 |
Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies. For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown. - Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmission - Provides a summary of the concepts of both population suppression and population replacement - Contains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies
| Author | : W. Takken |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 248 |
| Release | : 2003-07-31 |
| Genre | : Science |
| ISBN | : 9781402015854 |
This book is the reflection of a workshop, held in June 2002. Experts on mosquito ecology met for the first time to discuss the current knowledge of mosquito ecology with respect to GM-insect technology. Emphasis of the workshop was on evaluating how human health and natural ecosystems, including target wild-mosquito populations, will respond to the invasion of GM vectors. This volume will stimulate discussion by clearly showing the importance of vector ecology for prevention of vector-borne diseases.
| Author | : Mike Lehane |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 301 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 9401179530 |
Blood-sucking insects are the vectors of many of the most debilitating parasites of man and his domesticated animals. In addition they are of considerable direct cost to the agricultural industry through losses in milk and meat yields, and through damage to hides and wool, etc. So, not surprisingly, many books of medical and veterinary entomology have been written. Most of these texts are organized taxonomically giving the details of the life-cycles, bionomics, relationship to disease and economic importance of each of the insect groups in turn. I have taken a different approach. This book is topic led and aims to discuss the biological themes which are common in the lives of blood-sucking insects. To do this I have concentrated on those aspects of the biology of these fascinating insects which have been clearly modified in some way to suit the blood-sucking habit. For example, I have discussed feeding and digestion in some detail because feeding on blood presents insects with special problems, but I have not discussed respiration because it is not affected in any particular way by haematophagy. Naturally there is a subjective element in the choice of topics for discussion and the weight given to each. I hope that I have not let my enthusiasm for particular subjects get the better of me on too many occasions and that the subject material achieves an overall balance.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 384 |
| Release | : 2004-09-09 |
| Genre | : Medical |
| ISBN | : 0309165938 |
For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
| Author | : Serap Aksoy |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 187 |
| Release | : 2008-08-21 |
| Genre | : Science |
| ISBN | : 0387782257 |
Parasitic, bacterial and viral agents continue to challenge the welfare of humans, livestock, wild life and plants worldwide. The public health impact and financial consequences of these diseases are particularly hard on the already overburdened economies of developing countries especially in the tropics. Many of these disease agents utilize insect hosts (vectors) to achieve their transmission to mammals. In the past, these diseases were largely controlled by insecticide-based vector reduction strategies. Now, many of these diseases have reemerged in the tropics, recolonizing their previous range, and expanding into new territories previously not considered to be endemic. Habitat change, irrigation practices, atmospheric and climate change, insecticide and drug resistance as well as increases in global tourism, human traffic and commercial activities, have driven the reemergence and spread of vector borne diseases. While these diseases can be controlled through interventions aimed at both their vertebrate and invertebrate hosts, no effective vaccines exist, and only limited therapeutic prospects are available for their control in mammalian hosts. Molecular technologies such as transgenesis, which is the subject of this book, stand to increase the toolbox and benefit disease management strategies.
| Author | : Sylvie Manguin |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 454 |
| Release | : 2018-07-18 |
| Genre | : Medical |
| ISBN | : 1789235502 |
Towards Malaria Elimination - A Leap Forward was started to mark the occasion for renewed commitment to end malaria transmission for good (the WHO's call for "Malaria Free World" by 2030). This book is dedicated for the benefit of researchers, scientists, program and policy managers, students and anyone interested in malaria and other mosquito-borne diseases with the goal of sharing recent information on success stories, innovative control approaches and challenges in different regions of the world. Some main issues that emerged included multidrug-resistant malaria and pandemic risk, vaccines, cross-border malaria, asymptomatic parasite reservoir, the threat of Plasmodium vivax and Plasmodium knowlesi, insecticide resistance in Anopheles vectors and outdoor malaria transmission. This book is one little step forward to bring together in 17 chapters the experiences of malaria-expert researchers from five continents to present updated information on disease epidemiology and control at the national/regional level, highlighting the constraints, challenges, accomplishments and prospects of malaria elimination.
| Author | : V. Alistair Drake |
| Publisher | : Cambridge University Press |
| Total Pages | : 504 |
| Release | : 1995-09-14 |
| Genre | : Science |
| ISBN | : 0521440009 |
A comprehensive account of insect migration in its ecological and evolutionary context.
| Author | : Dyann Fergus Wirth |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2017 |
| Genre | : Medical |
| ISBN | : 9781621821229 |
Malaria is a mosquito-borne disease caused by parasitic protozoa that belong to the genus Plasmodium. This disease imposes a significant global health burden, claiming the lives of several thousand children and pregnant women each day. Increasing antimalarial drug resistance and the complexity of the Plasmodium life cycle, among other factors, have made eradication difficult. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the biology, pathology, and epidemiology of malaria, as well as ongoing efforts to treat infections and manage their spread. Contributors discuss the Plasmodium life cycle, focusing on the molecular mechanisms by which the various parasitic stages induce clinical symptoms, interact with the immune system, and lead to further transmission of malaria. They also explore topics such as the interaction between mosquito reproduction and Plasmodium development, epigenetic regulation of malaria-associated genes, and unique features of malaria in pregnant women (e.g., parity-dependent susceptibility) and describe how an improved understanding of these phenomena may lead to novel intervention strategies. The driving forces behind antimalarial drug resistance are covered, as is progress in developing an effective vaccine and controlling mosquito populations. This volume is therefore an essential reference for all scientists, clinicians, and public health professionals interested in understanding malaria and reducing its devastating effects.
