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| Author | : Christian Dahmann |
| Publisher | : Springer Nature |
| Total Pages | : 423 |
| Release | : 2022-08-18 |
| Genre | : Science |
| ISBN | : 1071625411 |
This third edition expands on the previous editions by providing updated protocols and current methods that cover recent breakthroughs in Drosophila research. Chapters guide readers through FlyBase, versatile gene expression systems, analysis of microRNA function, single-cell transcriptome data and metabolism, recent applications of CRISPR for precise genome editing, transcriptional activation and cell lineage tracing, protein inhibition and tagging, optogenetic and optochemical control of tissue mechanics, AFM measurements, sample preparation for electron microscopy, live imaging of different tissues and organs, and quantitative image analysis. Written in the format of the highly successful Methods in Molecular Biology series, chapters include an introduction to their topic, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls Authoritative and cutting-edge, Drosophila: Methods and Protocols, Third Edition serves as a useful and practical guide to new researchers and experts using Drosophila as a model system. Chapter 7 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
| Author | : Stanley I. Letovsky |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 298 |
| Release | : 2006-06-01 |
| Genre | : Science |
| ISBN | : 0306469030 |
Bioinformatics brings computational methods to the analysis and processing of genomic data. Bioinformatics: Databases and Systems focuses on the issues of system building and data curation that dominate the day-to-day concerns of bioinformatics practitioners. Included are chapters by many of today's leading bioinformatics practitioners, describing most of the current paradigms of system building and curation, including both their strengths and weaknesses. Biological topics covered include sequence databases, metabolic pathways, phenotypes, variety collections, gene expression atlases and neuroinformatics. Species range from bacteria to mammals to plants. Software systems and technologies covered include OPM, CORBA, SRS, KLEISLI, ACEDB, Web-based integration and laboratory workflow. Bioinformatics: Databases and Systems provides a valuable introduction for newcomers to the field, and a useful reference for veterans.
| Author | : Dan L. Lindsley |
| Publisher | : Academic Press |
| Total Pages | : 1144 |
| Release | : 2012-12-02 |
| Genre | : Science |
| ISBN | : 0323139841 |
Dedicated to the memory of George Lefevre in recognition of his exhaustive cytogenetic analysis of the X chromosome, The Genome of Drosophila melanogaster is the complete compendium of what is known about the genes and chromosomes of this widely used model organism. The volume is an up-to-date revision of Lindsley and Grell's 1968 work, Genetic Variations of Drosophila melanogaster. The new edition contains complete descriptions of normal and mutant genes including phenotypic, cytological, molecular, and bibliographic information. In addition, it describes thousands of recorded chromosome rearrangements used in research on Drosophila. This handbook and its accompanying polytene chromosome maps, are sturdily bound into the book as foldouts and available as a separate set, are essential research tools for the Drosophila community. Describes phenotype, cytology, and molecular biology of all recorded genes of Drosophila melanogaster, plus references to the literature Describes normal chromosome complement, special chromosome constructs, transposable elements, departures from diploidy, satellite sequences, and nonchromosomal inheritance Describes all recorded chromosome rearrangements of Drosophila melanogaster as of the end of 1989 Contains the cytogenetic map of all genes as of mid-1991 Contains the original polytene maps of C.B. Bridges, plus G. Lefevre's photographic equivalents, and the detailed maps of the chromosome arms produced by C.B. and P.M. Bridges All maps are reprinted as high-quality foldouts sturdily bound into the volume Maps may also be purchased separately in an eight-map packet, for laboratory and student use
| Author | : Vladimir I Titorenko |
| Publisher | : Frontiers Media SA |
| Total Pages | : 149 |
| Release | : 2015-03-05 |
| Genre | : Physiology |
| ISBN | : 2889194647 |
The peroxisome is an organelle with essential roles in lipid metabolism, maintenance of reactive oxygen species homeostasis, and anaplerotic replenishment of tricarboxylic acid cycle intermediates destined for mitochondria. Peroxisomes constitute a dynamic endomembrane system. The homeostatic state of this system is upheld via two pathways for assembling and maintaining the diverse peroxisomal compartments constituting it; the relative contribution of each pathway to preserving such system may vary in different organisms and under various physiological conditions. One pathway begins with the targeting of certain peroxisomal membrane proteins to an endoplasmic reticulum template and their exit from the template via pre-peroxisomal carriers; these carriers mature into metabolically active peroxisomes containing the entire complement of membrane and matrix proteins. Another pathway operates via growth and maturation of pre-existing peroxisomal precursors that do not originate from the endoplasmic reticulum; mature peroxisomes proliferate by undergoing fission. Recent studies have uncovered new roles for the peroxisomal endomembrane system in orchestrating important developmental decisions and defining organismal longevity. This Frontiers Special Topic Issue is focused on the advances in our understanding of how evolutionarily distant organisms coordinate the formation, maturation, proliferation, maintenance, inheritance and quality control of the peroxisomal endomembrane system and how peroxisomal endomembranes communicate with other cellular compartments to orchestrate complex biological processes and various developmental programs from inside the cell.
| Author | : Stephen M. King |
| Publisher | : Academic Press |
| Total Pages | : 686 |
| Release | : 2017-11-22 |
| Genre | : Science |
| ISBN | : 0128097027 |
Dyneins: The Biology of Dynein Motors, Second Edition, offers a broad view of dyneins from structure, composition and organization, to biology of dynein function in both cytoplasm and cilia. As the second book in a pair on this topic, these works provide an overview of dyneins, from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics and the consequences of defects for human biology, disease and development. This second edition is extensively revised, with coverage expanded from 24 to 42 chapters. Much of the expanded coverage occurs in Volume Two on dynein dysfunction and disease, such as the role of dynein and cancer, while Volume One covers the history and evolution of dyneins, dyneins in ciliary biology and cytoplasmic dynein biology. Presents a broad-based, up-to date view of the biology of dynein motors Discusses approaches from genetics, molecular biology, biochemistry and biophysics Includes a companion website with movies of dynamic cell behavior Covers the topic in comprehensive chapters written by world experts
| Author | : Shalini Suri |
| Publisher | : APH Publishing |
| Total Pages | : 292 |
| Release | : 2006 |
| Genre | : Bioinformatics |
| ISBN | : 9788131300121 |
With the advent of the new millennium, the scientific community marked a significant milestone in th study of bioinformation. This book attempts to keep up with the quick pace of change in this field, reinforcing concepts that have stood the test of time while making the reader aware of new approaches and algorithms that have emerged. This book is an essential reading for researchers, instructors, and students of all levels in molecular biology and bioinformatics, as well as for investigators involved in genomics, clinical research, proteomics, and computational biology.
| Author | : Eric C.R. Reeve |
| Publisher | : Routledge |
| Total Pages | : 985 |
| Release | : 2014-01-14 |
| Genre | : Reference |
| ISBN | : 1134263503 |
The Encyclopedia includes 125 entries, beginning with the origins of genetics including historical background on the work of Gregor Mendel and Charles Darwin, and progressing to the structure of DNA and modern theories such as selfish genes. All branches of genetics are covered, including the genetics of bacteria, viruses, insects, animals and plants, as well as humans. Important topical issues such as the human genome project, bioethics, the law and genetics, genetic disorders, GM crops, and the use of transgenic animals for food and pharmaceutical products are fully surveyed. A section on techniques and biotechnology includes modern methods of analysis, from DNA fingerprinting to the new science of bioinformatics. The articles, all written by specialists, are largely non-mathematical and progress from general concepts to deeper understanding. Each essay is fully referenced, with suggestions for further reading. The text is supplemented by extensive illustrations, tables and a color plate section. The Encyclopedia of Genetics will be a valuable companion for all those working or studying in the various fields of genetical research, and a fascinating reference for all readers with a basic background in biology. Also includes color inserts.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 789 |
| Release | : 1995-01-25 |
| Genre | : Science |
| ISBN | : 0080859429 |
Drosophila melanogaster: Practical Uses in Cell and Molecular Biology is a compendium of mostly short technical chapters designed to provide state-of-the art methods to the broad community of cell biologists, and to put molecular and cell biological studies of flies into perspective. The book makes the baroque aspects of genetic nomenclature and procedure accessible to cell biologists. It also contains a wealth of technical information for beginning or advanced Drosophila workers. Chapters, written within a year of publication, make this topical volume a valuable laboratory guide today and an excellent general reference for the future. Key Features* Collection of ready-to-use, state-of-the art methods for modern cell biological and related research using Drosophila melanogaster* Accessible to both experienced Drosophila researchers and to others who wish to join in at the cutting edge of this system * Drosophila offers an easily managed life cycle, inexpensive lifestyle, extraordinarily manipulable molecular and classical genetics, now combined with powerful new cell biology techniques * Introduction and overview sections orient the user to the Drosophila literature and lore * Six full-color plates and over 100 figures and tables enhance the understanding of these cell biology techniques
| Author | : Norman W. Paton |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 230 |
| Release | : 2009-07-21 |
| Genre | : Medical |
| ISBN | : 3642028799 |
Data integration in the life sciences continues to be important but challe- ing. The ongoing development of new experimental methods gives rise to an increasingly wide range of data sets, which in turn must be combined to allow more integrative views of biological systems. Indeed, the growing prominence of systems biology, where mathematical models characterize behaviors observed in experiments of di?erent types, emphasizes the importance of data integration to the life sciences. In this context, the representation of models of biological behavior as data in turn gives rise to challenges relating to provenance, data quality, annotation, etc., all of which are associated with signi?cant research activities within computer science. The Data Integration in the Life Sciences (DILS) Workshop Series brings together data and knowledge management researchers from the computer s- ence research community with bioinformaticians and computational biologists, to improve the understanding of how emerging data integration techniques can address requirements identi?ed in the life sciences.
| Author | : Giovanni Coppola |
| Publisher | : Oxford University Press |
| Total Pages | : 385 |
| Release | : 2014 |
| Genre | : Medical |
| ISBN | : 0199855455 |
The OMICs:Applications in Neuroscience summarizes the state of the art in OMICs applications in neurology and neuroscience, attracting neurologists who are interested in the progress of this field towards clinical applications, and neuroscientists who may be not familiar with the most recent advances in this ever-changing field. The book will include an overview of most relevant high-throughput approaches (collectively known as 'OMICs') and how they relate to neurology and neuroscience. The explosion of high-throughput assays has introduced large datasets, computational servers, and bioinformatics approaches to neuroscience and medicine in general. The reader will be provided with an overview of the application or method, a perspective on the current and future applications in neurology and neuroscience, and a few published examples illustrating possible practical use. Emerging topics such as ethical issues related to personal genome sequencing, epigenetics, network analysis, and role of peripheral biomarkers in disease diagnosis and follow-up will be covered as well.
