Fed Batch Cultures
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| Author | : Henry C. Lim |
| Publisher | : Cambridge University Press |
| Total Pages | : 477 |
| Release | : 2013-04-22 |
| Genre | : Technology & Engineering |
| ISBN | : 1107328128 |
Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal and sub-optimal fed-batch operations. Numerous examples are provided to illustrate the application of optimal fed-batch cultures. This unique book, by world experts with decades of research and industrial experience, is a must for researchers and industrial practitioners of fed-batch processes (modeling, control and optimization) in biotechnology, fermentation, food, pharmaceuticals and waste treatment industries.
| Author | : Henry C. Lim |
| Publisher | : Cambridge University Press |
| Total Pages | : 477 |
| Release | : 2013-04-22 |
| Genre | : Science |
| ISBN | : 0521513367 |
This first book dealing exclusively with every aspect of fed-batch operations, used in most industrially important fermentation and bioreactor operations.
| Author | : Gyun Min Lee |
| Publisher | : John Wiley & Sons |
| Total Pages | : 436 |
| Release | : 2020-01-13 |
| Genre | : Science |
| ISBN | : 3527343342 |
Offers a comprehensive overview of cell culture engineering, providing insight into cell engineering, systems biology approaches and processing technology In Cell Culture Engineering: Recombinant Protein Production, editors Gyun Min Lee and Helene Faustrup Kildegaard assemble top class authors to present expert coverage of topics such as: cell line development for therapeutic protein production; development of a transient gene expression upstream platform; and CHO synthetic biology. They provide readers with everything they need to know about enhancing product and bioprocess attributes using genome-scale models of CHO metabolism; omics data and mammalian systems biotechnology; perfusion culture; and much more. This all-new, up-to-date reference covers all of the important aspects of cell culture engineering, including cell engineering, system biology approaches, and processing technology. It describes the challenges in cell line development and cell engineering, e.g. via gene editing tools like CRISPR/Cas9 and with the aim to engineer glycosylation patterns. Furthermore, it gives an overview about synthetic biology approaches applied to cell culture engineering and elaborates the use of CHO cells as common cell line for protein production. In addition, the book discusses the most important aspects of production processes, including cell culture media, batch, fed-batch, and perfusion processes as well as process analytical technology, quality by design, and scale down models. -Covers key elements of cell culture engineering applied to the production of recombinant proteins for therapeutic use -Focuses on mammalian and animal cells to help highlight synthetic and systems biology approaches to cell culture engineering, exemplified by the widely used CHO cell line -Part of the renowned "Advanced Biotechnology" book series Cell Culture Engineering: Recombinant Protein Production will appeal to biotechnologists, bioengineers, life scientists, chemical engineers, and PhD students in the life sciences.
| Author | : Wei-Shu Hu |
| Publisher | : Springer |
| Total Pages | : 179 |
| Release | : 2006-08-16 |
| Genre | : Science |
| ISBN | : 3540340076 |
Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadening repertoire of protein drugs, has rapidly expanded the quantity needed for clinical applications. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity. More - portantly the productivity of cell culture processes has been driven upward by an order of magnitude in the past decade.
| Author | : Wei-Shou Hu |
| Publisher | : CRC Press |
| Total Pages | : 567 |
| Release | : 2020-03-06 |
| Genre | : Science |
| ISBN | : 0429531893 |
This book is the culmination of three decades of accumulated experience in teaching biotechnology professionals. It distills the fundamental principles and essential knowledge of cell culture processes from across many different disciplines and presents them in a series of easy-to-follow, comprehensive chapters. Practicality, including technological advances and best practices, is emphasized. This second edition consists of major updates to all relevant topics contained within this work. The previous edition has been successfully used in training courses on cell culture bioprocessing over the past seven years. The format of the book is well-suited to fast-paced learning, such as is found in the intensive short course, since the key take-home messages are prominently highlighted in panels. The book is also well-suited to act as a reference guide for experienced industrial practitioners of mammalian cell cultivation for the production of biologics.
| Author | : Virgínia Picanço-Castro |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2018-08-18 |
| Genre | : Science |
| ISBN | : 9781493984497 |
This volume covers a wide spectrum of techniques and approaches that are used in the upstream and downstream processing for recombinant glycoprotein production. Chapters guide the reader through state-of-art of therapeutic recombinant glycoproteins, explores the patent literature, expression systems used for glycoproteins production, methods employed in the downstream processing of different glycoproteins, and information about analytical tools and formulation strategies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Recombinant Glycoprotein Production: Methods and Protocols aims to ensure successful results in the further study of this vital field
| Author | : European Society of Animal Cell Technology. General Meeting |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 684 |
| Release | : 2001-11-30 |
| Genre | : Medical |
| ISBN | : 9781402002649 |
This book is the lasting product, a resource of up-to-date information in the scientific literature for the field of animal cell technology, as it was presented during a pleasant and stimulating meeting in Tylösand, Sweden, in June 2001. The title of the meeting, From Target to Market, indicates the usefulness of Animal Cell Technology during all steps in the pharmaceutical development process. Following the biotech products reaching the market, it shows an upward trend in the contribution of biotech products to total New Molecular Entity output in the nineties, which continued until 1996 when biotech represented 25% of the annual output. Since then the proportion has been decreasing. A perceived hurdle from a market perspective is that a protein per definition is biodegradable and thus requires intravenous, or for some drugs subcutaneous administration. New promising administration technologies such as pulmonary delivery were highlighted at this meeting. The emphasis on project selection prior to entry in the development phase has triggered a portfolio management using more extensive preclinical data before a development decision is taken. Animal cells have become a very important tool in the drug discovery process. The next generation of products will evolve from applications such as gene therapy, novel vaccines, cell therapy, and gene regulation. Animal cell technology has a major role to play in the post-sequence era.
| Author | : Francesca M. Kerton |
| Publisher | : John Wiley & Sons |
| Total Pages | : 310 |
| Release | : 2017-05-30 |
| Genre | : Science |
| ISBN | : 1119117186 |
Fuels, Chemicals and Materials from the Oceans and Aquatic Sources provides a holistic view of fuels, chemicals and materials from renewable sources in the oceans and other aquatic media. It presents established and recent results regarding the use of water-based biomass, both plants and animals,for value-added applications beyond food. The book begins with an introductory chapter which provides an overview of ocean and aquatic sources for the production of chemicals and materials. Subsequent chapters focus on the use of various ocean bioresources and feedstocks, including microalgae, macroalgae, and waste from aquaculture and fishing industries, including fish oils, crustacean and mollusc shells. Fuels, Chemicals and Materials from the Oceans and Aquatic Sources serves as a valuable reference for academic and industrial professionals working on the production of chemicals, materials and fuels from renewable feedstocks. It will also prove useful for researchers in the fields of green and sustainable chemistry, marine sciences and biotechnology. Topics covered include: • Production and conversion of green macroalgae • Marine macroalgal biomass as an energy feedstock • Microalgae bioproduction • Bioproduction and utilization of chitin and chitosan • Applications of mollusc shells • Crude fish oil as a potential fuel
| Author | : Ashok Pandey |
| Publisher | : Elsevier |
| Total Pages | : 480 |
| Release | : 2017-09-12 |
| Genre | : Technology & Engineering |
| ISBN | : 0444639918 |
Current Developments in Biotechnology and Bioengineering: Current Advances in Solid-State Fermentation provides knowledge and information on solid-state fermentation involving the basics of microbiology, biochemistry, molecular biology, genetics and principles of genetic engineering, metabolic engineering and biochemical engineering. This volume of the series is on Solid-State fermentation (SSF), which would cover the basic and applied aspects of SSF processes, including engineering aspects such as design of bioreactors in SSF. The book offers a pool of knowledge on biochemical and microbiological aspects as well as chemical and biological engineering aspects of SSF to provide an integrated knowledge and version to the readers. - Provides state-of-the-art information on basic and fundamental principles of solid-state fermentation - Includes key features for the education and understanding of biotechnology education and R&D, in particular on SSF - Lists fermentation methods for the production of a wide variety of enzymes and metabolites - Provides examples of the various industrial applications of enzymes in solid state fermentation
| Author | : Ajit Varma |
| Publisher | : Springer |
| Total Pages | : 459 |
| Release | : 2017-04-21 |
| Genre | : Science |
| ISBN | : 3319491970 |
This book provides essential molecular techniques and protocols for analyzing microbes that are useful for developing novel bio-chemicals, such as medicines, biofuels, and plant protection substances. The topics and techniques covered include: microbial diversity and composition; microorganisms in the food industry; mass cultivation of sebacinales; host-microbe interaction; targeted gene disruption; function-based metagenomics to reveal the rhizosphere microbiome; mycotoxin biosynthetic pathways; legume-rhizobium symbioses; multidrug transporters of yeast; drug-resistant bacteria; the fungal endophyte piriformospora indica; medicinal plants; arbuscular mycorrhizal fungi; biosurfactants in microbial enhanced oil recovery; and biocontrol of the soybean cyst nematode with root endophytic fungi; as well as microbe-mediated drought tolerance in plants.
