This issue of the Journal of Latin American Theology is dedicated to the memory of C. René Padilla (1932–2021). In “The Life and Legacy of C. René Padilla,” historian Daniel Salinas presents the essential events of René’s life and ministry. In 2008, Darren C. Marks published René’s own account of his theological journey in Shaping a Global Theological Mind. We are grateful to reprint “My Theological Pilgrimage,” in which René described the factors that contributed to his development as a theologian and practitioner. Next, the five children René had with his late wife Catharine Feser Padilla offer a heartfelt overview of their father’s life. A sample of tributes from friends and family members then describes not only René’s writings and mental brilliance but also his humility, hospitality, courage, and gentleness as a mentor. And the three poets included herein give testimony to René’s unflagging dedication to encouraging and publishing other writers across the genres. Next, historian Dinorah Méndez reviews René’s last literary venture, Raíces de un evangelio integral: misión en perspectiva histórica and demonstrates that the primary theological emphasis of René’s life—misión integral—has been practiced by the people of God in their various contexts throughout history. Finally, with the combined efforts of several scholars, we have compiled as complete a bibliography of René’s published works as possible.