Exploring Novel Chemotherapeutic Strategies In Breast Cancer
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| Author | : Lauren Himmel |
| Publisher | : |
| Total Pages | : |
| Release | : 2016 |
| Genre | : |
| ISBN | : |
Breast cancer is the most common cancer in women and is the second leading cause of cancer deaths among women in the United States, according to the CDC. Despite significant improvements in survival in recent decades, largely attributable to advances in screening methods, the prognosis for patients with advanced or metastatic disease remains poor. Broadly, this thesis work explores two main topics: alternative chemotherapeutic strategies for triple-negative breast cancer (TNBC) to prevent chemotherapy-induced cognitive impairment (CICI) and therapeutic targeting of breast cancer stem cells (BCSC). CICI describes a protracted state of cognitive decline that develops in breast cancer patients following treatment with cytotoxic chemotherapy, and is an important facet of survivor care. We propose that minocycline can be used to prevent CICI without abrogating the antitumor efficacy of adjuvant chemotherapy in models of TNBC. Next, we address BCSC, a subpopulation within mammary tumors which is believed to contribute to chemotherapeutic resistance, tumor recurrence, and metastasis. We have demonstrated that histone deacetylase inhibitors abrogate the BCSC phenotype in models of TNBC through a non-epigenetic effect of HDAC8 in maintaining Notch1 protein integrity. Thus, we suggest that HDAC8 may be translatable for CSC-targeted therapy in breast cancer and other malignancies. We also characterize a Her2 transgenic mouse model for the study of BCSC biology and therapeutic interventions. In these experiments, we have found that the HDAC inhibitor AR-42 demonstrates a potent antitumor effect through dual downregulation of Neu and Notch1, and that pharmacologic HDAC8 inhibition has a unique effect in modulating BCSC through multiple nodes in the Notch1 signalome. These findings suggest that this model could be useful in studying the role of mammary stem cells in tumorigenesis.
| Author | : Kwok-Leung Cheung |
| Publisher | : MDPI |
| Total Pages | : 264 |
| Release | : 2020-04-30 |
| Genre | : Medical |
| ISBN | : 3039287583 |
Treatment strategies for breast cancer are wide-ranging and often based on a multi-modality approach, depending on the stage and biology of the tumour and the acceptance and tolerance of the patient. They may include surgery, radiotherapy, and systemic therapy (endocrine therapy, chemotherapy, and targeted therapy). Advances in technologies such as oncoplastic surgery, radiation planning and delivery, and genomics, and the development of novel systemic therapy agents alongside their evaluation in ongoing clinical trials continue to strive for improvements in outcomes. In this Special Issue, we publish a collection of studies looking at all forms of therapeutic strategies for early and advanced breast cancer, focusing on their outcomes, notably survival.
| Author | : Kenneth D. Miller |
| Publisher | : JHU Press |
| Total Pages | : 457 |
| Release | : 2021-09-28 |
| Genre | : Health & Fitness |
| ISBN | : 142144190X |
"Providing comprehensive, current, and reliable information on breast cancer, this book, written by an experienced oncologist, a surgeon, and a breast cancer survivor, informs and inspires readers, wherever they are in the breast cancer experience. Patient stories, essays from medical specialists, and illustrations add clarity and insight"--
| Author | : Liwei Pang |
| Publisher | : Quality Research Publishing |
| Total Pages | : 0 |
| Release | : 2024-08-07 |
| Genre | : Medical |
| ISBN | : 9781022901254 |
In "Exploring Male Breast Cancer: Insights, Challenges, and Advances," a compilation of meticulously reviewed scientific journal articles sheds light on the often-overlooked condition of male breast cancer-a rare yet critical medical concern. Comprising only 1% of all breast cancer cases, male breast cancer presents unique clinical and socio-cultural challenges, as illustrated by diverse case studies from around the world, including Nigeria, India, and Burkina Faso. This book delves into the multifaceted aspects of the disease, from diagnosis and survival rates to treatment modalities such as primary surgical resection, chemotherapy, radiotherapy, and endocrine therapy. Key revelations include the trend of late-stage presentation and its dire impact on survival rates, urging a reevaluation of public health approaches. Novel treatment strategies, including dual HER2 blockade and innovative imaging techniques, are explored alongside discussions on endocrine therapy tailored for male patients. The volume also addresses the socio-economic and racial disparities in treatment outcomes, advocating for equitable healthcare access. A holistic view is presented with insights into the psychological strain faced by patients, emphasizing the need for comprehensive care that includes psychological support and patient education. Essential for medical professionals, researchers, and informed patients, this anthology paves the way for improved diagnostic and therapeutic protocols through continued research and collaboration. Quality Research Publishing is dedicated to making knowledge more accessible to the general public by curating a topical compilation of the latest research on various subjects and providing plain language summaries. Each of the articles in this book is available individually and digitally without cost. However, we believe it is important for the contextualizing and sharing of educational and scientific work to curate this research in a way that is understandable and helpful to the average person seeking deeper knowledge of a particular subject. The research articles compiled for this book were published under a permissive Creative Commons license, are in the public domain, or have no copyright restrictions, permitting their use in this book. If you have questions about the licensing of any article, please visit qualityresearchpublishing.com.
| Author | : Gw Sledge |
| Publisher | : Clinical Pub |
| Total Pages | : 0 |
| Release | : 2012-06 |
| Genre | : Breast |
| ISBN | : 9781846920660 |
This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.
| Author | : Robert Bazell |
| Publisher | : Random House |
| Total Pages | : 241 |
| Release | : 2011-04-27 |
| Genre | : Health & Fitness |
| ISBN | : 0307764982 |
Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free. Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers. Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.
| Author | : Alessandro Vespignani |
| Publisher | : World Scientific |
| Total Pages | : 264 |
| Release | : 2007-06-28 |
| Genre | : Computers |
| ISBN | : 9814475416 |
This book is the culmination of three years of research effort on a multidisciplinary project in which physicists, mathematicians, computer scientists and social scientists worked together to arrive at a unifying picture of complex networks. The contributed chapters form a reference for the various problems in data analysis visualization and modeling of complex networks.
| Author | : Richard A. Rettig |
| Publisher | : Oxford University Press |
| Total Pages | : 368 |
| Release | : 2007-01-25 |
| Genre | : Medical |
| ISBN | : 0199748241 |
In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or HDC/ABMT. By the 1990s, it had burst upon the oncology scene and disseminated rapidly before having been carefully evaluated. By the time published studies showed that the procedure was ineffective, more than 30,000 women had received the treatment, shortening their lives and adding to their suffering. This book tells of the rise and demise of HDC/ABMT for metastatic and early stage breast cancer, and fully explores the story's implications, which go well beyond the immediate procedure, and beyond breast cancer, to how we in the United States evaluate other medical procedures, especially life-saving ones. It details how the factors that drove clinical use--patient demand, physician enthusiasm, media reporting, litigation, economic exploitation, and legislative and administrative mandates--converged to propel the procedure forward despite a lack of proven clinical effectiveness. It also analyzes the limited effect of technology assessments before randomized clinical trials evaluated decisively the procedure and the ramifications of this system on healthcare today. Sections of the book consider the initial conditions surrounding the emergence of the new breast cancer treatment, the drivers of clinical use, and the struggle for evidence-based medicine. A concluding section considers the significance of the story for our healthcare system.
| Author | : Marc Silver |
| Publisher | : Rodale |
| Total Pages | : 338 |
| Release | : 2004-09-29 |
| Genre | : Medical |
| ISBN | : 1579548334 |
A guide for men whose wives contract breast cancer offers emotional support and advice every husband needs, including guidance from breast cancer doctors and the shared experiences of those who have gone through the same ordeal. Original. 30,000 first printing.
| Author | : Kenneth K.W. To |
| Publisher | : Academic Press |
| Total Pages | : 460 |
| Release | : 2020-07-29 |
| Genre | : Science |
| ISBN | : 0128199032 |
Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types
