Download Exploration Of Salvinorin A Chemical Space full books in PDF, epub, and Kindle. Read online free Exploration Of Salvinorin A Chemical Space ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
| Author | : A. Douglas Kinghorn |
| Publisher | : Springer Nature |
| Total Pages | : 274 |
| Release | : 2019-10-16 |
| Genre | : Science |
| ISBN | : 3030146324 |
The book summarizes important aspects of cheminformatics that are relevant for natural product research. It highlights cheminformatics tools that help to match natural products with their respective biological targets or off-targets, and discusses the potential and limitations of this approach.
| Author | : Daniel Oberhaus |
| Publisher | : MIT Press |
| Total Pages | : 265 |
| Release | : 2024-05-07 |
| Genre | : Science |
| ISBN | : 026254864X |
If we send a message into space, will extraterrestrial beings receive it? Will they understand? The endlessly fascinating question of whether we are alone in the universe has always been accompanied by another, more complicated one: if there is extraterrestrial life, how would we communicate with it? In this book, Daniel Oberhaus leads readers on a quest for extraterrestrial communication. Exploring Earthlings' various attempts to reach out to non-Earthlings over the centuries, he poses some not entirely answerable questions: If we send a message into space, will extraterrestrial beings receive it? Will they understand? What languages will they (and we) speak? Is there not only a universal grammar (as Noam Chomsky has posited), but also a grammar of the universe? Oberhaus describes, among other things, a late-nineteenth-century idea to communicate with Martians via Morse code and mirrors; the emergence in the twentieth century of SETI (the search for extraterrestrial intelligence), CETI (communication with extraterrestrial intelligence), and finally METI (messaging extraterrestrial intelligence); the one-way space voyage of Ella, an artificial intelligence agent that can play cards, tell fortunes, and recite poetry; and the launching of a theremin concert for aliens. He considers media used in attempts at extraterrestrial communication, from microwave systems to plaques on spacecrafts to formal logic, and discusses attempts to formulate a language for our message, including the Astraglossa and two generations of Lincos (lingua cosmica). The chosen medium for interstellar communication reveals much about the technological sophistication of the civilization that sends it, Oberhaus observes, but even more interesting is the information embedded in the message itself. In Extraterrestrial Languages, he considers how philosophy, linguistics, mathematics, science, and art have informed the design or limited the effectiveness of our interstellar messaging.
| Author | : P. Gopalakrishnakone |
| Publisher | : |
| Total Pages | : |
| Release | : |
| Genre | : Plant toxins |
| ISBN | : 9789400767287 |
| Author | : J. D. Arthur |
| Publisher | : Simon and Schuster |
| Total Pages | : 84 |
| Release | : 2010-02-17 |
| Genre | : Social Science |
| ISBN | : 1594779724 |
One man’s personal journey through the unparalleled trance states of salvia • Originally published as Peopled Darkness • Contains real-life descriptions of salvia-induced visionary experiences • Offers guidance for the responsible use of this psychoactive plant • Explores the shamanic awareness associated with salvia Salvia divinorum, which recently entered the visionary pharmacopoeia of the modern world, has been used for centuries in the shamanic practices of the Mazatec Indians of Oaxaca, Mexico, for healing and divination. A member of the Mint family, Salvia divinorum--“diviner’s sage”--offers a new doorway to the visionary pursuit of higher spiritual and meditative states. With repeated sessions using salvia over the course of several years, J. D. Arthur began returning each time to the same inner landscape where he found himself entering a unique state of thought-free, or “thoughtless,” awareness. There he accessed a mode of “dream language” that communicated an exquisite constellation of detailed meanings swiftly and flawlessly. His repeated immersion in these states of trance, as well as his analysis of their approach and withdrawal, led to a profound reassessment of the nature of normal perception and a reevaluation of what we refer to as the real world. With true-life descriptions of salvia-induced visionary states, this book offers a detailed experiential analysis for those interested in exploring salvia in their quest for higher knowledge.
| Author | : Beatriz Caiuby Labate |
| Publisher | : Springer |
| Total Pages | : 239 |
| Release | : 2018-04-28 |
| Genre | : Medical |
| ISBN | : 3319767208 |
This is a book about the intersections of three dimensions. The first is the way social scientists and historians treat the history of psychiatry and healing, especially as it intersects with psychedelics. The second encompasses a reflection on the substances themselves and their effects on bodies. The third addresses traditional healing, as it circles back to our understanding of drugs and psychiatry. The chapters explore how these dimensions are distinct, but deeply intertwined, themes that offer important insights into contemporary healing practices. The intended audience of the volume is large and diverse: neuroscientists, biologists, medical doctors, psychiatrists, psychologists; mental health professionals interested in the therapeutic application of psychedelic substances, or who work with substance abuse, depression, anxiety, and PTSD; patients and practitioners of complementary and alternative medicine; ethnobotanists and ethnopharmacologists; lawyers, criminologists, and other specialists in international law working on matters related to drug policy and human rights, as well as scholars of religious studies, anthropologists, sociologists, and historians; social scientists concerned both with the history of science, medicine, and technology, and concepts of health, illness, and healing. It has a potentially large international audience, especially considering the increasing interest in “psychedelic science” and the growing spread of the use of traditional psychoactives in the West.
| Author | : Lee-Yuan Liu-Chen |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2022 |
| Genre | : |
| ISBN | : 9783030890759 |
This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds. It is divided up into the three parts: Molecular aspects of KOR, Preclinical research on pharmacology of KOR agonists and antagonists in animals and KOR agonists and antagonists in clinical use and in past and present clinical trials. The chapters "Biosensors monitor ligand-selective effects at kappa opioid receptors" and "The role of dynorphin and the kappa opioid receptor in schizophrenia and major depressive disorder: a translational approach" of this book are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
| Author | : Jie Jack Li |
| Publisher | : John Wiley & Sons |
| Total Pages | : 688 |
| Release | : 2013-04-26 |
| Genre | : Science |
| ISBN | : 1118354435 |
Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.
| Author | : Viktor V. Zhdankin |
| Publisher | : John Wiley & Sons |
| Total Pages | : 630 |
| Release | : 2013-10-01 |
| Genre | : Science |
| ISBN | : 1118341309 |
Hypervalent Iodine Chemistry is the first comprehensive text covering all of the main aspects of the chemistry of organic and inorganic polyvalent iodine compounds, including applications in chemical research, medicine, and industry. Providing a comprehensive overview of the preparation, properties, and synthetic applications of this important class of reagents, the text is presented in the following way: The introductory chapter provides a historical background and describes the general classification of iodine compounds, nomenclature, hypervalent bonding, structural features, and the principles of reactivity of polyvalent iodine compounds. Chapter 2 gives a detailed description of the preparative methods and structural features of all known classes of organic and inorganic derivatives of polyvalent iodine. Chapter 3, the key chapter of the book, deals with the many applications of hypervalent iodine reagents in organic synthesis. Chapter 4 describes the most recent achievements in hypervalent iodine catalysis. Chapter 5 deals with recyclable polymer-supported and nonpolymeric hypervalent iodine reagents. Chapter 6 covers the "green" reactions of hypervalent iodine reagents under solvent-free conditions or in aqueous solutions. The final chapter provides an overview of the important practical applications of polyvalent iodine compounds in medicine and industry. This book is aimed at all chemists interested in iodine compounds, including academic and industrial researchers in inorganic, organic, physical, medicinal, and biological chemistry. It will be particularly useful to synthetic organic and inorganic chemists, including graduate and advanced undergraduate students. It comprehensively covers the green chemistry aspects of hypervalent iodine chemistry, making it especially useful for industrial chemists.
| Author | : Alexander Hillisch |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 314 |
| Release | : 2002-12-11 |
| Genre | : Medical |
| ISBN | : 9783764360818 |
Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.
| Author | : Rick Strassman |
| Publisher | : Simon and Schuster |
| Total Pages | : 216 |
| Release | : 2022-08-09 |
| Genre | : Health & Fitness |
| ISBN | : 1646043839 |
Learn everything you need to know about psychedelics with this ultimate guide packed with information on popular psychedelic drugs like psilocybin, ketamine, MDMA, DMT and LSD—plus practical tips for microdosing and how to safely "trip"—from bestselling author Dr. Rick Strassman. Entering the world of psychedelic drugs can be challenging, and many aren’t sure where to start. As research continues to expand and legalization looms on the horizon for psychedelics like psilocybin, you may need a guide to navigate what psychedelics are, how they work, and their potential benefits and risks. The Psychedelic Handbook is a complete manual that is accessible to anyone with an interest in these “mind-manifesting” substances. Packed with information on psilocybin, LSD, DMT/ayahuasca, mescaline/peyote, ketamine, MDMA, ibogaine, 5-methoxy-DMT (“the toad”), and Salvia divinorum/salvinorin A, this book is your ultimate reference for understanding the science and history of psychedelics; discovering their potential to treat depression, PTSD, substance abuse, and other disorders, as well as to increase wellness, creativity, and meditation; learning how to safely trip and explaining what we know about microdosing; and recognizing and caring for negative reactions to psychedelics. Clinical research psychiatrist, founding figure of the American psychedelic research renaissance, and best-selling author of DMT: The Spirit Molecule, Dr. Rick Strassman shares his experience and perspectives as neither advocate nor foe of psychedelics in order to help readers understand the effects of these remarkable drugs.
