Good Research Practice in Non-Clinical Pharmacology and Biomedicine

Good Research Practice in Non-Clinical Pharmacology and Biomedicine
Author: Anton Bespalov
Publisher: Springer Nature
Total Pages: 424
Release: 2020-01-01
Genre: Cardiology
ISBN: 3030336565

This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

Methylxanthines

Methylxanthines
Author: Bertil B. Fredholm
Publisher: Springer Science & Business Media
Total Pages: 566
Release: 2010-09-22
Genre: Medical
ISBN: 3642134432

In the present volume of the Handbook of Experimental Pharmacology well known experts describe the actions of different xanthines with a focus on caffeine and theophylline. A special chapter is devoted to theobromine, an active component of chocolate, the actions of which are less well characterized. This book also presents the pharmacology of one xanthine derivative, propentofylline, as an example of a xanthine that has gone through extensive development for a novel therapeutic area.

Concepts and Principles of Pharmacology

Concepts and Principles of Pharmacology
Author: James E. Barrett
Publisher: Springer Nature
Total Pages: 457
Release: 2019-12-24
Genre: Medical
ISBN: 3030353621

Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

Pediatric Clinical Pharmacology

Pediatric Clinical Pharmacology
Author: Hannsjörg W. Seyberth
Publisher: Springer Science & Business Media
Total Pages: 385
Release: 2011-09-01
Genre: Medical
ISBN: 3642201954

The objective of this volume is to give an overview of the present state of the art of pediatric clinical pharmacology including developmental physiology, pediatric-specific pathology, special tools and methods for development of drugs for children (assessment of efficacy, toxicity, long-term safety etc.) as well as regulatory and ethical knowledge and skills. In the future, structural and educational changes have to lead back to a closer cooperation and interaction of pediatrics with (clinical) pharmacology and pharmacy.

New Psychoactive Substances

New Psychoactive Substances
Author: Hans H. Maurer
Publisher: Springer
Total Pages: 563
Release: 2019-02-20
Genre: Medical
ISBN: 303010561X

This volume is designed to feature the pharmacology of new psychoactive substances, legislative aspects, information exchange including epidemiology, and clinical, forensic, and analytical toxicology in order to facilitate the understanding of this complex and rapidly developing phenomenon.

Gastrointestinal Pharmacology

Gastrointestinal Pharmacology
Author: Beverley Greenwood-Van Meerveld
Publisher: Springer
Total Pages: 446
Release: 2017-04-19
Genre: Medical
ISBN: 3319563602

This volume aims to connect current ideas and concepts about GI disorders with the search for novel therapeutics. Towards this goal, authors provide a timely state-of-the-art overview of the GI tract in health and disease, current treatment approaches and ongoing developments in drug discovery, and their potential for the better treatment of patients with GI disorders.

Drug Delivery

Drug Delivery
Author: Binghe Wang
Publisher: John Wiley & Sons
Total Pages: 740
Release: 2016-04-18
Genre: Science
ISBN: 1118833368

Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery

Experimental Therapeutics

Experimental Therapeutics
Author: Martin Wilkins
Publisher: CRC Press
Total Pages: 248
Release: 2003-03-27
Genre: Medical
ISBN: 9781841842905

As a general rule, for every 10,000 molecules screened in a given program in the laboratory, only one will survive to launch. To minimize costs, companies need to catch potential failures, due either to lack of clinical effect or toxicity, in the early discovery phase, long before they reach patients. Experimental Therapeutics introduces the dynamic and competitive discipline of experimental medicine. Informative, concise, and easy-to-read, the book emphasizes what scientists involved in drug discovery need to know about the rapid advances made in molecular biology, genetics, and technology. Each chapter starts with a summary box, has several high yield boxes, tables, and figures and ends with a reference section that has key URLs and carefully selected references to scientific papers. The book is a useful primer for anyone working to advance the pharmacological management of disease.

Reactive Oxygen Species

Reactive Oxygen Species
Author: Harald H. H. W. Schmidt
Publisher: Springer Nature
Total Pages: 425
Release: 2021-02-23
Genre: Medical
ISBN: 3030685101

Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Drugs on Trial

Drugs on Trial
Author: Andreas-Holger Maehle
Publisher: Rodopi
Total Pages: 388
Release: 1999
Genre: Chemotherapy
ISBN: 9789042007833

This book describes the main issues of eighteenth-century pharmacology and therapeutics and provides detailed case studies of three key areas: lithontriptics (remedies against urinary stones), opium, and Peruvian bark (quinine).